{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:34Z","timestamp":1790776594712,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T00:00:00Z","timestamp":1346198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s10875-012-9755-3","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T13:23:19Z","timestamp":1346160199000},"page":"30-39","source":"Crossref","is-referenced-by-count":178,"title":["Use of Combination Chemotherapy for Treatment of Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD) in Patients with Common Variable Immunodeficiency (CVID)"],"prefix":"10.1007","volume":"33","author":[{"given":"Nicole M.","family":"Chase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Verbsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Hintermeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill K.","family":"Waukau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoy","family":"Tomita-Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Casper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushik S.","family":"Shahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Tisol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melodee L.","family":"Nugent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Nagarjun","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Craig","family":"Mackinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence R.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Routes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,29]]},"reference":[{"issue":"Suppl 1","key":"9755_CR1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2249.2009.03954.x","volume":"157","author":"B Gathmann","year":"2009","unstructured":"Gathmann B, Grimbacher B, Beaute J, Dudoit Y, Mahlaoui N, Fischer A, et al. The European internet-based patient and research database for primary immunodeficiencies: results 2006\u20132008. Clin Exp Immunol. 2009;157 Suppl 1:3\u201311.","journal-title":"Clin Exp Immunol"},{"issue":"5 Suppl 1","key":"9755_CR2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1081-1206(10)61142-8","volume":"94","author":"FA Bonilla","year":"2005","unstructured":"Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol. 2005;94(5 Suppl 1):S1\u2013S63.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"9755_CR3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11882-001-0027-1","volume":"1","author":"C Cunningham-Rundles","year":"2001","unstructured":"Cunningham-Rundles C. Common variable immunodeficiency. Curr Allergy Asthma Rep. 2001;1(5):421\u20139.","journal-title":"Curr Allergy Asthma Rep"},{"issue":"6","key":"9755_CR4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1067\/mai.2002.124999","volume":"109","author":"PJ Busse","year":"2002","unstructured":"Busse PJ, Razvi S, Cunningham-Rundles C. Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency. J Allergy Clin Immunol. 2002;109(6):1001\u20134.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"9755_CR5","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jaci.2010.02.040","volume":"125","author":"M Lucas","year":"2010","unstructured":"Lucas M, Lee M, Lortan J, Lopez-Granados E, Misbah S, Chapel H. Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22\u00a0years. J Allergy Clin Immunol. 2010;125(6):1354\u201360 e4.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"9755_CR6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ajh.2830370202","volume":"37","author":"C Cunningham-Rundles","year":"1991","unstructured":"Cunningham-Rundles C, Lieberman P, Hellman G, Chaganti RS. Non-Hodgkin lymphoma in common variable immunodeficiency. Am J Hematol. 1991;37(2):69\u201374.","journal-title":"Am J Hematol"},{"issue":"4","key":"9755_CR7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF00915550","volume":"7","author":"C Cunningham-Rundles","year":"1987","unstructured":"Cunningham-Rundles C, Siegal FP, Cunningham-Rundles S, Lieberman P. Incidence of cancer in 98 patients with common varied immunodeficiency. J Clin Immunol. 1987;7(4):294\u20139.","journal-title":"J Clin Immunol"},{"issue":"8423","key":"9755_CR8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(85)91037-2","volume":"1","author":"LJ Kinlen","year":"1985","unstructured":"Kinlen LJ, Webster AD, Bird AG, Haile R, Peto J, Soothill JF, et al. Prospective study of cancer in patients with hypogammaglobulinaemia. Lancet. 1985;1(8423):263\u20136.","journal-title":"Lancet"},{"issue":"12","key":"9755_CR9","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00000478-199212000-00004","volume":"16","author":"CA Sander","year":"1992","unstructured":"Sander CA, Medeiros LJ, Weiss LM, Yano T, Sneller MC, Jaffe ES. Lymphoproliferative lesions in patients with common variable immunodeficiency syndrome. Am J Surg Pathol. 1992;16(12):1170\u201382.","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"9755_CR10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2007-11-124545","volume":"112","author":"H Chapel","year":"2008","unstructured":"Chapel H, Lucas M, Lee M, Bjorkander J, Webster D, Grimbacher B, et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood. 2008;112(2):277\u201386.","journal-title":"Blood"},{"issue":"7","key":"9755_CR11","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","volume":"119","author":"ES Resnick","year":"2012","unstructured":"Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood. 2012;119(7):1650\u20137.","journal-title":"Blood"},{"issue":"1","key":"9755_CR12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","volume":"111","author":"C Wehr","year":"2008","unstructured":"Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood. 2008;111(1):77\u201385.","journal-title":"Blood"},{"issue":"2","key":"9755_CR13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2004.05.057","volume":"114","author":"CA Bates","year":"2004","unstructured":"Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM. Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol. 2004;114(2):415\u201321.","journal-title":"J Allergy Clin Immunol"},{"issue":"8 Pt 1","key":"9755_CR14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.7326\/0003-4819-127-8_Part_1-199710150-00005","volume":"127","author":"LJ Mechanic","year":"1997","unstructured":"Mechanic LJ, Dikman S, Cunningham-Rundles C. Granulomatous disease in common variable immunodeficiency. Ann Intern Med. 1997;127(8 Pt 1):613\u20137.","journal-title":"Ann Intern Med"},{"issue":"5","key":"9755_CR15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s11882-005-0008-x","volume":"5","author":"Y Morimoto","year":"2005","unstructured":"Morimoto Y, Routes JM. Granulomatous disease in common variable immunodeficiency. Curr Allergy Asthma Rep. 2005;5(5):370\u20135.","journal-title":"Curr Allergy Asthma Rep"},{"issue":"2","key":"9755_CR16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.clim.2009.10.002","volume":"134","author":"JH Park","year":"2010","unstructured":"Park JH, Levinson AI. Granulomatous-lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). Clin Immunol. 2010;134(2):97\u2013103.","journal-title":"Clin Immunol"},{"issue":"Suppl 1","key":"9755_CR17","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1007\/s10875-008-9182-7","volume":"28","author":"C Cunningham-Rundles","year":"2008","unstructured":"Cunningham-Rundles C. Autoimmune manifestations in common variable immunodeficiency. J Clin Immunol. 2008;28 Suppl 1:S42\u20135.","journal-title":"J Clin Immunol"},{"issue":"12","key":"9755_CR18","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1097\/PAS.0b013e3180cab60c","volume":"31","author":"JA Daniels","year":"2007","unstructured":"Daniels JA, Lederman HM, Maitra A, Montgomery EA. Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol. 2007;31(12):1800\u201312.","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"9755_CR19","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1007\/s10620-006-9736-6","volume":"52","author":"A Khodadad","year":"2007","unstructured":"Khodadad A, Aghamohammadi A, Parvaneh N, Rezaei N, Mahjoob F, Bashashati M, et al. Gastrointestinal manifestations in patients with common variable immunodeficiency. Dig Dis Sci. 2007;52(11):2977\u201383.","journal-title":"Dig Dis Sci"},{"issue":"1","key":"9755_CR20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jhep.2007.08.011","volume":"48","author":"G Malamut","year":"2008","unstructured":"Malamut G, Ziol M, Suarez F, Beaugrand M, Viallard JF, Lascaux AS, et al. Nodular regenerative hyperplasia: the main liver disease in patients with primary hypogammaglobulinemia and hepatic abnormalities. J Hepatol. 2008;48(1):74\u201382.","journal-title":"J Hepatol"},{"key":"9755_CR21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/B978-0-12-385991-4.00002-7","volume":"111","author":"PF Yong","year":"2011","unstructured":"Yong PF, Thaventhiran JE, Grimbacher B. \u201cA rose is a rose is a rose,\u201d but CVID is Not CVID common variable immune deficiency (CVID), what do we know in 2011? Adv Immunol. 2011;111:47\u2013107.","journal-title":"Adv Immunol"},{"issue":"6","key":"9755_CR22","first-page":"454","volume":"21","author":"H Abolhassani","year":"2011","unstructured":"Abolhassani H, Aghamohammadi A, Abolhassani F, Eftekhar H, Heidarnia M, Rezaei N. Health policy for common variable immunodeficiency: burden of the disease. J Investig Allergol Clin Immunol. 2011;21(6):454\u20138.","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"3","key":"9755_CR23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/RTI.0b013e318166d32f","volume":"23","author":"DA Torigian","year":"2008","unstructured":"Torigian DA, LaRosa DF, Levinson AI, Litzky LA, Miller Jr WT. Granulomatous-lymphocytic interstitial lung disease associated with common variable immunodeficiency: CT findings. J Thorac Imaging. 2008;23(3):162\u20139.","journal-title":"J Thorac Imaging"},{"key":"9755_CR24","unstructured":"MacDermott RP. Immunomodulator therapy in Crohn\u2019s disease. In: UpToDate. Basow DS, editor. Waltham, MA: UpToDate; 2012."},{"key":"9755_CR25","unstructured":"MacDermott RP. 6-mercaptopurine (6-MP) metabolite monitoring and TPMT testing in the treatment of inflammatory bowel disease with 6-MP or azathioprine. In: UpToDate. Basow DS, editor. Waltham, MA: UpToDate; 2012."},{"issue":"6","key":"9755_CR26","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.rmed.2008.12.015","volume":"103","author":"S Gregersen","year":"2009","unstructured":"Gregersen S, Aalokken TM, Mynarek G, Kongerud J, Aukrust P, Froland SS, et al. High resolution computed tomography and pulmonary function in common variable immunodeficiency. Respir Med. 2009;103(6):873\u201380.","journal-title":"Respir Med"},{"issue":"2","key":"9755_CR27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319\u201338.","journal-title":"Eur Respir J"},{"issue":"3","key":"9755_CR28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1183\/09031936.05.00035005","volume":"26","author":"J Wanger","year":"2005","unstructured":"Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, et al. Standardisation of the measurement of lung volumes. Eur Respir J. 2005;26(3):511\u201322.","journal-title":"Eur Respir J"},{"issue":"6","key":"9755_CR29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/cyto.b.20536","volume":"78","author":"B Piatosa","year":"2010","unstructured":"Piatosa B, Wolska-Kusnierz B, Pac M, Siewiera K, Galkowska E, Bernatowska E. B cell subsets in healthy children: reference values for evaluation of B cell maturation process in peripheral blood. Cytometry B Clin Cyto. 2010;78(6):372\u201381.","journal-title":"Cytometry B Clin Cyto"},{"issue":"3","key":"9755_CR30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-3476(97)70200-2","volume":"130","author":"WM Comans-Bitter","year":"1997","unstructured":"Comans-Bitter WM, de Groot R, van den Beemd R, Neijens HJ, Hop WC, Groeneveld K, et al. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. J Pediatr. 1997;130(3):388\u201393.","journal-title":"J Pediatr"},{"issue":"8","key":"9755_CR31","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","volume":"37","author":"U Salzer","year":"2005","unstructured":"Salzer U, Chapel HM, Webster AD, Pan-Hammarstrom Q, Schmitt-Graeff A, Schlesier M, et al. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet. 2005;37(8):820\u20138.","journal-title":"Nat Genet"},{"issue":"5","key":"9755_CR32","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s10875-010-9424-3","volume":"30","author":"G Mouillot","year":"2010","unstructured":"Mouillot G, Carmagnat M, Gerard L, Garnier JL, Fieschi C, Vince N, et al. B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease. J Clin Immunol. 2010;30(5):746\u201355.","journal-title":"J Clin Immunol"},{"issue":"9","key":"9755_CR33","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1182\/blood-2008-02-141937","volume":"113","author":"U Salzer","year":"2008","unstructured":"Salzer U, Bacchelli C, Buckridge S, Pan-Hammarstrom Q, Jennings S, Lougaris V, et al. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood. 2008;113(9):1967\u201376.","journal-title":"Blood"},{"issue":"4","key":"9755_CR34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/MOH.0b013e328302c7b6","volume":"15","author":"I Chua","year":"2008","unstructured":"Chua I, Quinti I, Grimbacher B. Lymphoma in common variable immunodeficiency: interplay between immune dysregulation, infection and genetics. Curr Opin Hematol. 2008;15(4):368\u201374.","journal-title":"Curr Opin Hematol"},{"issue":"5","key":"9755_CR35","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jaci.2005.08.041","volume":"116","author":"AZ Hatab","year":"2005","unstructured":"Hatab AZ, Ballas ZK. Caseating granulomatous disease in common variable immunodeficiency treated with infliximab. J Allergy Clin Immunol. 2005;116(5):1161\u20132.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"9755_CR36","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jaci.2006.01.034","volume":"117","author":"JH Lin","year":"2006","unstructured":"Lin JH, Liebhaber M, Roberts RL, Dyer Z, Stiehm ER. Etanercept treatment of cutaneous granulomas in common variable immunodeficiency. J Allergy Clin Immunol. 2006;117(4):878\u201382.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"9755_CR37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1081-1206(10)61228-8","volume":"95","author":"A Thatayatikom","year":"2005","unstructured":"Thatayatikom A, Thatayatikom S, White AJ. Infliximab treatment for severe granulomatous disease in common variable immunodeficiency: a case report and review of the literature. Ann Allergy Asthma Immunol. 2005;95(3):293\u2013300.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"9755_CR38","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","volume":"26","author":"R Pellegrino","year":"2005","unstructured":"Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948\u201368.","journal-title":"Eur Respir J"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-012-9755-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-012-9755-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-012-9755-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T04:14:51Z","timestamp":1559276091000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-012-9755-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,29]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["9755"],"URL":"https:\/\/doi.org\/10.1007\/s10875-012-9755-3","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,29]]}}}