{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:01:46Z","timestamp":1791842506496,"version":"4.3.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:00:00Z","timestamp":1401753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s10875-014-0064-x","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T10:19:25Z","timestamp":1401704365000},"page":"686-690","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Novel NFKB2 Mutation in Early-Onset CVID"],"prefix":"10.1007","volume":"34","author":[{"given":"Yiwen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmalal","family":"Gurugama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnaby","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A A","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,3]]},"reference":[{"issue":"7","key":"64_CR1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3466","volume":"13","author":"A Durandy","year":"2013","unstructured":"Durandy A, Kracker S, Fischer A. Primary antibody deficiencies. Nat Rev Immunol. 2013;13(7):519\u201333.","journal-title":"Nat Rev Immunol"},{"key":"64_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2011.00054","volume":"2","author":"W Al-Herz","year":"2011","unstructured":"Al-Herz W, Bousfiha A, Casanova J-L, Chapel H, Conley ME, Cunningham-Rundles C, et al. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol. 2011;2:1\u201326.","journal-title":"Front Immunol"},{"key":"64_CR3","doi-asserted-by":"crossref","unstructured":"Park JH, Resnick ES, Cunningham-Rundles C, Annals NYAS. Perspectives on common variable immune deficiency. Year in Human and Medical Genetics: Inborn Errors of Immunity Ii. 2011;1246:41\u20139.","DOI":"10.1111\/j.1749-6632.2011.06338.x"},{"issue":"5","key":"64_CR4","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ajhg.2013.09.009","volume":"93","author":"K Chen","year":"2013","unstructured":"Chen K, Coonrod EM, Kumanovics A, Franks ZF, Durtschi JD, Margraf RL, et al. Germline Mutations in NFKB2 Implicate the Noncanonical NF-kappaB Pathway in the Pathogenesis of Common Variable Immunodeficiency. Am J Hum Genet. 2013;93(5):812\u201324.","journal-title":"Am J Hum Genet"},{"issue":"11","key":"64_CR5","doi-asserted-by":"crossref","first-page":"7514","DOI":"10.4049\/jimmunol.179.11.7514","volume":"179","author":"E Tucker","year":"2007","unstructured":"Tucker E, O\u2019Donnel K, Fuchsberger M, Hilton AA, Metcalft D, Greig K, et al. A novel mutation in the Nfkb2 gene generates-an NF-kappa B2 \u201cSuper repressor\u201d. J Immunol. 2007;179(11):7514\u201322.","journal-title":"J Immunol"},{"issue":"1","key":"64_CR6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2010.177","volume":"21","author":"S-C Sun","year":"2011","unstructured":"Sun S-C. Non-canonical NF-kappa B signaling pathway. Cell Res. 2011;21(1):71\u201385.","journal-title":"Cell Res"},{"issue":"8","key":"64_CR7","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.cellsig.2005.10.011","volume":"18","author":"CY Liang","year":"2006","unstructured":"Liang CY, Zhang MY, Sun SC. beta-TrCP binding and processing of NF-kappa B2\/p100 involve its phosphorylation at serines 866 and 870. Cell Signal. 2006;18(8):1309\u201317.","journal-title":"Cell Signal"},{"issue":"7446","key":"64_CR8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature12058","volume":"496","author":"H Xu","year":"2013","unstructured":"Xu H, Li X, Liu D, Li J, Zhang X, Chen X, et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature. 2013;496(7446):523\u20137.","journal-title":"Nature"},{"issue":"12","key":"64_CR9","doi-asserted-by":"crossref","first-page":"8180","DOI":"10.4049\/jimmunol.179.12.8180","volume":"179","author":"VL Bryant","year":"2007","unstructured":"Bryant VL, Ma CS, Avery DT, Li Y, Good KL, Corcoran LM, et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: Predominant role of IL-21 produced by CXCR5(+) T follicular helper cells. J Immunol. 2007;179(12):8180\u201390.","journal-title":"J Immunol"},{"issue":"2","key":"64_CR10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4049\/jimmunol.1201697","volume":"190","author":"MLG Torchia","year":"2013","unstructured":"Torchia MLG, Conze DB, Jankovic D, Ashwell JD. Balance between NF-kappa B p100 and p52 Regulates T Cell Costimulation Dependence. J Immunol. 2013;190(2):549\u201355.","journal-title":"J Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-014-0064-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-014-0064-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-014-0064-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T05:34:41Z","timestamp":1565501681000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-014-0064-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,3]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["64"],"URL":"https:\/\/doi.org\/10.1007\/s10875-014-0064-x","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,3]]}}}