{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:21:12Z","timestamp":1761744072830},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s10875-015-0128-6","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T04:40:46Z","timestamp":1422420046000},"page":"218-226","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["An Impaired Inflammatory Cytokine Response to Gram-Negative LPS in Human Neonates is Associated with the Defective TLR-Mediated Signaling Pathway"],"prefix":"10.1007","volume":"35","author":[{"given":"Yi Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng Lin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue Guang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang Huai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,29]]},"reference":[{"key":"128_CR1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(05)71048-5","volume":"365","author":"JE Lawn","year":"2005","unstructured":"Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: when? where? why? Lancet. 2005;365:891\u2013900.","journal-title":"Lancet"},{"key":"128_CR2","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","volume":"379","author":"L Liu","year":"2012","unstructured":"Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379:2151\u201361.","journal-title":"Lancet"},{"key":"128_CR3","doi-asserted-by":"crossref","first-page":"e1001080","DOI":"10.1371\/journal.pmed.1001080","volume":"8","author":"MZ Oestergaard","year":"2011","unstructured":"Oestergaard MZ, Inoue M, Yoshida S, et al. Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of progress, projections, and priorities. PLoS Med. 2011;8:e1001080.","journal-title":"PLoS Med"},{"key":"128_CR4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ni0311-189","volume":"12","author":"M PrabhuDas","year":"2011","unstructured":"PrabhuDas M, Adkins B, Gans H, et al. Challenges in infant immunity: implications for responses to infection and vaccines. Nat Immunol. 2011;12:189\u201394.","journal-title":"Nat Immunol"},{"key":"128_CR5","first-page":"25","volume-title":"Infections diseases of the fetus and newborn infant","author":"DB Lewis","year":"2006","unstructured":"Lewis DB, Wilson CB. Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection. In: Klein JO, Remington JS, Wilson CB, Baker CJ, editors. Infections diseases of the fetus and newborn infant. 6th ed. Elsevier Saunders: Philadelphia; 2006. p. 25\u2013128.","edition":"6"},{"key":"128_CR6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nri2075","volume":"7","author":"O Levy","year":"2007","unstructured":"Levy O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol. 2007;7:379\u201390.","journal-title":"Nat Rev Immunol"},{"key":"128_CR7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri1394","volume":"4","author":"B Adkins","year":"2004","unstructured":"Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol. 2004;4:553\u201364.","journal-title":"Nat Rev Immunol"},{"key":"128_CR8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.20080996","volume":"206","author":"CJ Haines","year":"2009","unstructured":"Haines CJ, Giffon TD, Lu LS, et al. Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. J Exp Med. 2009;206:275\u201385.","journal-title":"J Exp Med"},{"key":"128_CR9","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1182\/blood-2008-08-173658","volume":"113","author":"SJ Opiela","year":"2009","unstructured":"Opiela SJ, Koru-Sengul T, Adkins B. Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood. 2009;113:5635\u201343.","journal-title":"Blood"},{"key":"128_CR10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri2508","volume":"9","author":"CA Siegrist","year":"2009","unstructured":"Siegrist CA, Aspinall R. B-cell responses to vaccination at the extremes of age. Nat Rev Immunol. 2009;9:185\u201394.","journal-title":"Nat Rev Immunol"},{"key":"128_CR11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000323934","volume":"3","author":"A Guilmot","year":"2011","unstructured":"Guilmot A, Hermann E, Braud VM, Carlier Y, Truyens C. Natural killer cell responses to infections in early life. J Innate Immunol. 2011;3:280\u20138.","journal-title":"J Innate Immunol"},{"key":"128_CR12","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1128\/IAI.01291-10","volume":"79","author":"AG Cuenca","year":"2011","unstructured":"Cuenca AG, Wynn JL, Kelly-Scumpia KM, et al. Critical role for CXC ligand 10\/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun. 2011;79:2746\u201354.","journal-title":"Infect Immun"},{"key":"128_CR13","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1128\/IAI.74.4.1999-2006.2006","volume":"74","author":"L Marodi","year":"2006","unstructured":"Marodi L. Neonatal innate immunity to infectious agents. Infect Immun. 2006;74:1999\u20132006.","journal-title":"Infect Immun"},{"key":"128_CR14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11:373\u201384.","journal-title":"Nat Immunol"},{"key":"128_CR15","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","volume":"282","author":"A Poltorak","year":"1998","unstructured":"Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085\u20138.","journal-title":"Science"},{"key":"128_CR16","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.4049\/jimmunol.165.10.5392","volume":"165","author":"O Takeuchi","year":"2000","unstructured":"Takeuchi O, Hoshino K, Akira S. Cutting edge: TLR2 deficient and MyD88 deficient mice are highly susceptible to Staphlycoccus aureus infection. J Immunol. 2000;165:5392\u20136.","journal-title":"J Immunol"},{"key":"128_CR17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1286-4579(00)00298-7","volume":"2","author":"R Landmann","year":"2000","unstructured":"Landmann R, Muller B, Zimmerli W. CD14, new aspects of ligand and signal diversity. Microbes Infect. 2000;2:295\u2013304.","journal-title":"Microbes Infect"},{"key":"128_CR18","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1126\/science.1698311","volume":"249","author":"SD Wright","year":"1990","unstructured":"Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 1990;249:1431\u20133.","journal-title":"Science"},{"key":"128_CR19","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.182.6.1673","volume":"182","author":"T Kusunoki","year":"1995","unstructured":"Kusunoki T, Hailman E, Juan TS, Lichenstein HS, Wright SD. Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses. J Exp Med. 1995;182:1673\u201382.","journal-title":"J Exp Med"},{"key":"128_CR20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4:499\u2013511.","journal-title":"Nat Rev Immunol"},{"key":"128_CR21","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/eji.201243077","volume":"43","author":"Q Zhang","year":"2013","unstructured":"Zhang Q, Coveney AP, Yu S. Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection. Eur J Immunol. 2013;43:1322\u201332.","journal-title":"Eur J Immunol"},{"key":"128_CR22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.clim.2003.11.009","volume":"110","author":"PO Krutzik","year":"2004","unstructured":"Krutzik PO, Irish JM, Nolan GP, et al. Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clin Immunol. 2004;110:206\u201321.","journal-title":"Clin Immunol"},{"key":"128_CR23","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1172\/JCI115493","volume":"88","author":"C Munoz","year":"1991","unstructured":"Munoz C, Carlet J, Fitting C, et al. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest. 1991;88:1747\u201354.","journal-title":"J Clin Invest"},{"key":"128_CR24","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1182\/blood-2008-01-130500","volume":"112","author":"JL Wynn","year":"2008","unstructured":"Wynn JL, Scumpia PO, Winfield RD, et al. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood. 2008;112:1750\u20138.","journal-title":"Blood"},{"key":"128_CR25","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.4049\/jimmunol.0901481","volume":"183","author":"TR Kollmann","year":"2009","unstructured":"Kollmann TR, Crabtree J, Rein-Weston A, et al. Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol. 2009;183:7150\u201360.","journal-title":"J Immunol"},{"key":"128_CR26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000243926","volume":"63","author":"AM Peters","year":"1993","unstructured":"Peters AM, Bertram P, Gahr M, Speer CP. Reduced secretion of interleukin-1 and tumor necrosis factor-alpha by neonatal monocytes. Biol Neonate. 1993;63:157\u201362.","journal-title":"Biol Neonate"},{"key":"128_CR27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/09680519050110020701","volume":"11","author":"O Levy","year":"2005","unstructured":"Levy O. Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists. J Endotoxin Res. 2005;11:113\u20136.","journal-title":"J Endotoxin Res"},{"key":"128_CR28","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.4049\/jimmunol.173.7.4627","volume":"173","author":"O Levy","year":"2004","unstructured":"Levy O, Zarember KA, Roy RM, et al. Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. J Immunol. 2004;173:4627\u201334.","journal-title":"J Immunol"},{"key":"128_CR29","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000255165","volume":"97","author":"JE Caron","year":"2010","unstructured":"Caron JE, La Pine TR, Augustine NH, Martins TB, Hill HR. Multiplex analysis of toll-like receptor-stimulated neonatal cytokine response. Neonatol. 2010;97:266\u201373.","journal-title":"Neonatol"},{"key":"128_CR30","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1128\/IAI.72.3.1223-1229.2004","volume":"72","author":"SR Yan","year":"2004","unstructured":"Yan SR, Qing G, Byers DM, et al. Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide. Infect Immun. 2004;72:1223\u20139.","journal-title":"Infect Immun"},{"key":"128_CR31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jaci.2010.09.020","volume":"127","author":"MK Tulic","year":"2011","unstructured":"Tulic MK, Hodder M, Forsberg A, et al. Differences in innate immune function between allergic and nonallergic children:new insights into immune ontogeny. J Allergy Clin Immunol. 2011;127:470\u20138.","journal-title":"J Allergy Clin Immunol"},{"key":"128_CR32","doi-asserted-by":"crossref","unstructured":"Liao SL, Yeh KW, Lai SH, Lee WI, Huang JL. Maturation of toll-like receptor 1\u20134 responsiveness during early life. Early Hum Dev. 2013;89:473\u20138.","DOI":"10.1016\/j.earlhumdev.2013.03.013"},{"key":"128_CR33","doi-asserted-by":"crossref","unstructured":"Sadeghi K, Berger A, Langgartner M, et al. Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling. J Infect Dis. 2007;195:296\u2013302.","DOI":"10.1086\/509892"},{"key":"128_CR34","doi-asserted-by":"crossref","unstructured":"Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol. 2003;15:677\u201382.","DOI":"10.1016\/S0952-7915(03)00080-3"},{"key":"128_CR35","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1096158","volume":"304","author":"JM Blander","year":"2004","unstructured":"Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from Toll-like receptors. Science. 2004;304:1014\u20138.","journal-title":"Science"},{"key":"128_CR36","doi-asserted-by":"crossref","unstructured":"Viemann D, Dubbel G, Schleifenbaum S, et al. Expression of toll-like receptors in neonatal sepsis. Pediatr Res. 2005;58:654\u20139.","DOI":"10.1203\/01.PDR.0000180544.02537.FD"},{"key":"128_CR37","doi-asserted-by":"crossref","unstructured":"Dasari P, Zola H, Nicholson IC. Expression of Toll-like receptors by neonatal leukocytes. Pediatr Allergy Immunol. 2011;22:221\u20138","DOI":"10.1111\/j.1399-3038.2010.01091.x"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-015-0128-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-015-0128-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-015-0128-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T05:35:39Z","timestamp":1566279339000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-015-0128-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,29]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["128"],"URL":"https:\/\/doi.org\/10.1007\/s10875-015-0128-6","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,29]]}}}