{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:42:32Z","timestamp":1786981352149,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s10875-016-0307-0","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T01:51:41Z","timestamp":1466387501000},"page":"564-570","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis"],"prefix":"10.1007","volume":"36","author":[{"given":"Joel","family":"Gallagher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hintermeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy R.","family":"Torgerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Lopez-Guisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans D.","family":"Ochs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Salib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Verbsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Routes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"issue":"2","key":"307_CR1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12016-013-8378-7","volume":"46","author":"N Qamar","year":"2014","unstructured":"Qamar N, Fuleihan RL. The hyper IgM syndromes. Clin Rev Allergy Immunol. 2014;46(2):120\u201330.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"8","key":"307_CR2","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s10875-013-9951-9","volume":"33","author":"BK Al-Saud","year":"2013","unstructured":"Al-Saud BK, Al-Sum Z, Alassiri H, Al-Ghonaium A, Al-Muhsen S, Al-Dhekri H, et al. Clinical, immunological, and molecular characterization of hyper-IgM syndrome due to CD40 deficiency in eleven patients. J Clin Immunol. 2013;33(8):1325\u201335.","journal-title":"J Clin Immunol"},{"issue":"22","key":"307_CR3","doi-asserted-by":"crossref","first-page":"12614","DOI":"10.1073\/pnas.221456898","volume":"98","author":"S Ferrari","year":"2001","unstructured":"Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A. 2001;98(22):12614\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"307_CR4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","volume":"102","author":"P Revy","year":"2000","unstructured":"Revy P, Muto T, Levy Y, Geissmann F, Plebani A, Sanal O, et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell. 2000;102(5):565\u201375.","journal-title":"Cell"},{"issue":"10","key":"307_CR5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/ni974","volume":"4","author":"K Imai","year":"2003","unstructured":"Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, Catalan N, et al. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat Immunol. 2003;4(10):1023\u20138.","journal-title":"Nat Immunol"},{"issue":"2","key":"307_CR6","first-page":"101","volume":"3","author":"LD Notarangelo","year":"1992","unstructured":"Notarangelo LD, Duse M, Ugazio AG. Immunodeficiency with hyper-IgM (HIM). Immunodefic Rev. 1992;3(2):101\u201321.","journal-title":"Immunodefic Rev"},{"issue":"6","key":"307_CR7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.md.0000100046.06009.b0","volume":"82","author":"JA Winkelstein","year":"2003","unstructured":"Winkelstein JA, Marino MC, Ochs H, Fuleihan R, Scholl PR, Geha R, et al. The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. Medicine (Baltimore). 2003;82(6):373\u201384.","journal-title":"Medicine (Baltimore)"},{"issue":"1 Pt 1","key":"307_CR8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(97)70123-9","volume":"131","author":"J Levy","year":"1997","unstructured":"Levy J, Espanol-Boren T, Thomas C, Fischer A, Tovo P, Bordigoni P, et al. Clinical spectrum of X-linked hyper-IgM syndrome. J Pediatr. 1997;131(1 Pt 1):47\u201354.","journal-title":"J Pediatr"},{"issue":"5","key":"307_CR9","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1182\/blood-2003-12-4420","volume":"105","author":"WI Lee","year":"2005","unstructured":"Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD. Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood. 2005;105(5):1881\u201390.","journal-title":"Blood"},{"issue":"6","key":"307_CR10","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1073\/pnas.90.6.2170","volume":"90","author":"R Fuleihan","year":"1993","unstructured":"Fuleihan R, Ramesh N, Loh R, Jabara H, Rosen RS, Chatila T, et al. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc Natl Acad Sci U S A. 1993;90(6):2170\u20133.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6412","key":"307_CR11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/361541a0","volume":"361","author":"JP DiSanto","year":"1993","unstructured":"DiSanto JP, Bonnefoy JY, Gauchat JF, Fischer A, de Saint Basile G. CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM. Nature. 1993;361(6412):541\u20133.","journal-title":"Nature"},{"issue":"6412","key":"307_CR12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/361539a0","volume":"361","author":"U Korthauer","year":"1993","unstructured":"Korthauer U, Graf D, Mages HW, Briere F, Padayachee M, Malcolm S, et al. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature. 1993;361(6412):539\u201341.","journal-title":"Nature"},{"issue":"2","key":"307_CR13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0092-8674(93)90668-G","volume":"72","author":"A Aruffo","year":"1993","unstructured":"Aruffo A, Farrington M, Hollenbaugh D, Li X, Milatovich A, Nonoyama S, et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell. 1993;72(2):291\u2013300.","journal-title":"Cell"},{"issue":"5097","key":"307_CR14","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.7679801","volume":"259","author":"RC Allen","year":"1993","unstructured":"Allen RC, Armitage RJ, Conley ME, Rosenblatt H, Jenkins NA, Copeland NG, et al. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science. 1993;259(5097):990\u20133.","journal-title":"Science"},{"issue":"4","key":"307_CR15","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1172\/JCI3409","volume":"102","author":"K Agematsu","year":"1998","unstructured":"Agematsu K, Nagumo H, Shinozaki K, Hokibara S, Yasui K, Terada K, et al. Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome. J Clin Invest. 1998;102(4):853\u201360.","journal-title":"J Clin Invest"},{"issue":"7","key":"307_CR16","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1182\/blood.V92.7.2421","volume":"92","author":"K Seyama","year":"1998","unstructured":"Seyama K, Nonoyama S, Gangsaas I, Hollenbaugh D, Pabst HF, Aruffo A, et al. Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome. Blood. 1998;92(7):2421\u201334.","journal-title":"Blood"},{"issue":"1","key":"307_CR17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12026-015-8638-0","volume":"62","author":"G Lopez-Herrera","year":"2015","unstructured":"Lopez-Herrera G, Maravillas-Montero JL, Vargas-Hernandez A, Berron-Ruiz L, Ramirez-Sanchez E, Yamazaki-Nakashimada MA, et al. A novel CD40LG deletion causes the hyper-IgM syndrome with normal CD40L expression in a 6-month-old child. Immunol Res. 2015;62(1):89\u201394.","journal-title":"Immunol Res"},{"issue":"1 Pt 1","key":"307_CR18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0022-3476(97)70139-2","volume":"131","author":"R Ameratunga","year":"1997","unstructured":"Ameratunga R, Lederman HM, Sullivan KE, Ochs HD, Seyama K, French JK, et al. Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome. J Pediatr. 1997;131(1 Pt 1):147\u201350.","journal-title":"J Pediatr"},{"issue":"8","key":"307_CR19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1172\/JCI5891","volume":"103","author":"A Jain","year":"1999","unstructured":"Jain A, Atkinson TP, Lipsky PE, Slater JE, Nelson DL, Strober W. Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome. J Clin Invest. 1999;103(8):1151\u20138.","journal-title":"J Clin Invest"},{"issue":"5","key":"307_CR20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0022-3476(99)70245-3","volume":"134","author":"CK Cunningham","year":"1999","unstructured":"Cunningham CK, Bonville CA, Ochs HD, Seyama K, John PA, Rotbart HA, et al. Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome. J Pediatr. 1999;134(5):584\u20138.","journal-title":"J Pediatr"},{"issue":"2","key":"307_CR21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1086\/515633","volume":"178","author":"K Seyama","year":"1998","unstructured":"Seyama K, Kobayashi R, Hasle H, Apter AJ, Rutledge JC, Rosen D, et al. Parvovirus B19-induced anemia as the presenting manifestation of X-linked hyper-IgM syndrome. J Infect Dis. 1998;178(2):318\u201324.","journal-title":"J Infect Dis"},{"issue":"4","key":"307_CR22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/A:1027337923709","volume":"18","author":"LE Leiva","year":"1998","unstructured":"Leiva LE, Junprasert J, Hollenbaugh D, Sorensen RU. Central nervous system toxoplasmosis with an increased proportion of circulating gamma delta T cells in a patient with hyper-IgM syndrome. J Clin Immunol. 1998;18(4):283\u201390.","journal-title":"J Clin Immunol"},{"issue":"2","key":"307_CR23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s10875-013-9980-4","volume":"34","author":"O Cabral-Marques","year":"2014","unstructured":"Cabral-Marques O, Klaver S, Schimke LF, Ascendino EH, Khan TA, Pereira PV, et al. First report of the hyper-IgM syndrome registry of the Latin American society for immunodeficiencies: novel mutations, unique infections, and outcomes. J Clin Immunol. 2014;34(2):146\u201356.","journal-title":"J Clin Immunol"},{"issue":"2","key":"307_CR24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s10875-011-9623-6","volume":"32","author":"O Cabral-Marques","year":"2012","unstructured":"Cabral-Marques O, Schimke LF, Pereira PV, Falcai A, de Oliveira JB, Hackett MJ, et al. Expanding the clinical and genetic spectrum of human CD40L deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in Brazilian patients. J Clin Immunol. 2012;32(2):212\u201320.","journal-title":"J Clin Immunol"},{"issue":"3","key":"307_CR25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1365-2249.2000.01142.x","volume":"120","author":"LD Notarangelo","year":"2000","unstructured":"Notarangelo LD, Hayward AR. X-linked immunodeficiency with hyper-IgM (XHIM). Clin Exp Immunol. 2000;120(3):399\u2013405.","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"307_CR26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.clim.2008.08.005","volume":"129","author":"M Erdos","year":"2008","unstructured":"Erdos M, Garami M, Rakoczi E, Zalatnai A, Steinbach D, Baumann U, et al. Neuroendocrine carcinoma associated with X-linked hyper-immunoglobulin M syndrome: report of four cases and review of the literature. Clin Immunol. 2008;129(3):455\u201361.","journal-title":"Clin Immunol"},{"issue":"2","key":"307_CR27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4049\/jimmunol.158.2.977","volume":"158","author":"AR Hayward","year":"1997","unstructured":"Hayward AR, Levy J, Facchetti F, Notarangelo L, Ochs HD, Etzioni A, et al. Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked immunodeficiency with hyper-IgM. J Immunol. 1997;158(2):977\u201383.","journal-title":"J Immunol"},{"issue":"Suppl 1","key":"307_CR28","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1007\/s10875-008-9171-x","volume":"28","author":"AA Jesus","year":"2008","unstructured":"Jesus AA, Duarte AJ, Oliveira JB. Autoimmunity in hyper-IgM syndrome. J Clin Immunol. 2008;28 Suppl 1:S62\u20136.","journal-title":"J Clin Immunol"},{"issue":"1","key":"307_CR29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4049\/jimmunol.166.1.353","volume":"166","author":"A Kumanogoh","year":"2001","unstructured":"Kumanogoh A, Wang X, Lee I, Watanabe C, Kamanaka M, Shi W, et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J Immunol. 2001;166(1):353\u201360.","journal-title":"J Immunol"},{"issue":"9","key":"307_CR30","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.4049\/jimmunol.162.9.5601","volume":"162","author":"S Lacroix-Desmazes","year":"1999","unstructured":"Lacroix-Desmazes S, Resnick I, Stahl D, Mouthon L, Espanol T, Levy J, et al. Defective self-reactive antibody repertoire of serum IgM in patients with hyper-IgM syndrome. J Immunol. 1999;162(9):5601\u20138.","journal-title":"J Immunol"},{"issue":"2","key":"307_CR31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)81349-5","volume":"87","author":"JC Rathmell","year":"1996","unstructured":"Rathmell JC, Townsend SE, Xu JC, Flavell RA, Goodnow CC. Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell. 1996;87(2):319\u201329.","journal-title":"Cell"},{"issue":"7","key":"307_CR32","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20062287","volume":"204","author":"M Herve","year":"2007","unstructured":"Herve M, Isnardi I, Ng YS, Bussel JB, Ochs HD, Cunningham-Rundles C, et al. CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance. J Exp Med. 2007;204(7):1583\u201393.","journal-title":"J Exp Med"},{"issue":"1","key":"307_CR33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ajh.20044","volume":"76","author":"D Tomizawa","year":"2004","unstructured":"Tomizawa D, Imai K, Ito S, Kajiwara M, Minegishi Y, Nagasawa M, et al. Allogeneic hematopoietic stem cell transplantation for seven children with X-linked hyper-IgM syndrome: a single center experience. Am J Hematol. 2004;76(1):33\u20139.","journal-title":"Am J Hematol"},{"issue":"1","key":"307_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/petr.12012","volume":"17","author":"N Rezaei","year":"2013","unstructured":"Rezaei N, Notarangelo LD. Hematopoietic stem cell transplantation for hyper-IgM syndromes. Pediatr Transplant. 2013;17(1):1\u20132.","journal-title":"Pediatr Transplant"},{"issue":"4","key":"307_CR35","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jaci.2015.02.020","volume":"136","author":"K Mitsui-Sekinaka","year":"2015","unstructured":"Mitsui-Sekinaka K, Imai K, Sato H, Tomizawa D, Kajiwara M, Nagasawa M, et al. Clinical features and hematopoietic stem cell transplantations for CD40 ligand deficiency in Japan. J Allergy Clin Immunol. 2015;136(4):1018\u201324.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"307_CR36","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1182\/blood-2003-06-2014","volume":"103","author":"AR Gennery","year":"2004","unstructured":"Gennery AR, Khawaja K, Veys P, Bredius RG, Notarangelo LD, Mazzolari E, et al. Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993\u20132002. Blood. 2004;103(3):1152\u20137.","journal-title":"Blood"},{"issue":"6","key":"307_CR37","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1442-200X.2007.02468.x","volume":"49","author":"T Sato","year":"2007","unstructured":"Sato T, Kobayashi R, Toita N, Kaneda M, Hatano N, Iguchi A, et al. Stem cell transplantation in primary immunodeficiency disease patients. Pediatr Int. 2007;49(6):795\u2013800.","journal-title":"Pediatr Int"},{"issue":"26","key":"307_CR38","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1056\/NEJMra023226","volume":"349","author":"BC Trapnell","year":"2003","unstructured":"Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med. 2003;349(26):2527\u201339.","journal-title":"N Engl J Med"},{"issue":"4","key":"307_CR39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000101347","volume":"91","author":"A Hamvas","year":"2007","unstructured":"Hamvas A, Cole FS, Nogee LM. Genetic disorders of surfactant proteins. Neonatology. 2007;91(4):311\u20137.","journal-title":"Neonatology"},{"issue":"2","key":"307_CR40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1164\/rccm.2109105","volume":"166","author":"JF Seymour","year":"2002","unstructured":"Seymour JF, Presneill JJ. Pulmonary alveolar proteinosis: progress in the first 44 years. Am J Respir Crit Care Med. 2002;166(2):215\u201335.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"307_CR41","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood-2013-07-515528","volume":"123","author":"MA Spinner","year":"2014","unstructured":"Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, et al. GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 2014;123(6):809\u201321.","journal-title":"Blood"},{"issue":"1","key":"307_CR42","first-page":"117","volume":"97","author":"B Mahut","year":"1996","unstructured":"Mahut B, Delacourt C, Scheinmann P, de Blic J, Mani TM, Fournet JC, et al. Pulmonary alveolar proteinosis: experience with eight pediatric cases and a review. Pediatrics. 1996;97(1):117\u201322.","journal-title":"Pediatrics"},{"issue":"6","key":"307_CR43","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1001\/archpedi.1971.02100170063006","volume":"121","author":"AR Colon Jr","year":"1971","unstructured":"Colon Jr AR, Lawrence RD, Mills SD, O\u2019Connell EJ. Childhood pulmonary alveolar proteinosis (PAP). Report of a case and review of the literature. Am J Dis Child. 1971;121(6):481\u20135.","journal-title":"Am J Dis Child"},{"issue":"3","key":"307_CR44","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/15513819209023316","volume":"12","author":"M Fisher","year":"1992","unstructured":"Fisher M, Roggli V, Merten D, Mulvihill D, Spock A. Coexisting endogenous lipoid pneumonia, cholesterol granulomas, and pulmonary alveolar proteinosis in a pediatric population: a clinical, radiographic, and pathologic correlation. Pediatr Pathol. 1992;12(3):365\u201383.","journal-title":"Pediatr Pathol"},{"issue":"6","key":"307_CR45","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0002-9343(86)90683-2","volume":"80","author":"FL Ruben","year":"1986","unstructured":"Ruben FL, Talamo TS. Secondary pulmonary alveolar proteinosis occurring in two patients with acquired immune deficiency syndrome. Am J Med. 1986;80(6):1187\u201390.","journal-title":"Am J Med"},{"issue":"7","key":"307_CR46","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/ppul.20818","volume":"43","author":"T Patiroglu","year":"2008","unstructured":"Patiroglu T, Akyildiz B, Patiroglu TE, Gulmez IY. Recurrent pulmonary alveolar proteinosis secondary to agammaglobulinemia. Pediatr Pulmonol. 2008;43(7):710\u20133.","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"307_CR47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.smim.2009.05.011","volume":"21","author":"J Suttles","year":"2009","unstructured":"Suttles J, Stout RD. Macrophage CD40 signaling: a pivotal regulator of disease protection and pathogenesis. Semin Immunol. 2009;21(5):257\u201364.","journal-title":"Semin Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-016-0307-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-016-0307-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-016-0307-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T19:25:00Z","timestamp":1692386700000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-016-0307-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,20]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["307"],"URL":"https:\/\/doi.org\/10.1007\/s10875-016-0307-0","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,20]]}}}