{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:54:05Z","timestamp":1786971245316,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24AI086037"],"award-info":[{"award-number":["U24AI086037"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wallace Chair of Pediatrics"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s10875-017-0415-5","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T11:41:17Z","timestamp":1501242077000},"page":"592-602","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Two Sides of the Same Coin: Pediatric-Onset and Adult-Onset Common Variable Immune Deficiency"],"prefix":"10.1007","volume":"37","author":[{"name":"the USIDNET Consortium","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solrun Melkorka","family":"Maggadottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Pantell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lugar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Cunningham","family":"Rundles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"415_CR1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1006\/clim.1999.4799","volume":"93","author":"ME Conley","year":"1999","unstructured":"Conley ME, Notarangelo LD, Etzioni A. Diagnostic criteria for primary immunodeficiencies. Representing PAGID (pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin Immunol. 1999;93:190\u20137.","journal-title":"Clin Immunol"},{"key":"415_CR2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10875-007-9103-1","volume":"27","author":"JM Boyle","year":"2007","unstructured":"Boyle JM, Buckley RH. Population prevalence of diagnosed primary immunodeficiency diseases in the United States. J Clin Immunol. 2007;27:497\u2013502.","journal-title":"J Clin Immunol"},{"key":"415_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.anai.2015.06.012","volume":"115","author":"KE Sullivan","year":"2015","unstructured":"Sullivan KE, Boyle M, Nauman E, Carton T. Health care utilization by patients with common variable immune deficiency defined by international classification of diseases, ninth revision code 279.06. Ann Allergy Asthma Immunol. 2015;115:248\u201350.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"415_CR4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1182\/blood-2007-11-124545","volume":"112","author":"H Chapel","year":"2008","unstructured":"Chapel H, Lucas M, Lee M, Bjorkander J, Webster D, Grimbacher B, et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood. 2008;112:277\u201386.","journal-title":"Blood"},{"key":"415_CR5","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","volume":"119","author":"ES Resnick","year":"2012","unstructured":"Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood. 2012;119:1650\u20137.","journal-title":"Blood"},{"key":"415_CR6","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S0022-3476(86)80927-1","volume":"108","author":"ME Conley","year":"1986","unstructured":"Conley ME, Park CL, Douglas SD. Childhood common variable immunodeficiency with autoimmune disease. J Pediatr. 1986;108:915\u201322.","journal-title":"J Pediatr"},{"key":"415_CR7","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1001\/archpedi.1983.02140350011004","volume":"137","author":"C Hausser","year":"1983","unstructured":"Hausser C, Virelizier JL, Buriot D, Griscelli C. Common variable hypogammaglobulinemia in children. Clinical and immunologic observations in 30 patients. Am J Dis Child. 1983;137:833\u20137.","journal-title":"Am J Dis Child"},{"key":"415_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1006\/clim.1999.4725","volume":"92","author":"C Cunningham-Rundles","year":"1999","unstructured":"Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92:34\u201348.","journal-title":"Clin Immunol"},{"key":"415_CR9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","volume":"134","author":"B Gathmann","year":"2014","unstructured":"Gathmann B, Mahlaoui N, Ceredih GL, Oksenhendler E, Warnatz K, et al. Clinical picture and treatment of 2212 patients with common variable immunodeficiency. J Allergy Clin Immunol. 2014;134:116\u201326.","journal-title":"J Allergy Clin Immunol"},{"key":"415_CR10","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3389\/fimmu.2016.00220","volume":"7","author":"P Maffucci","year":"2016","unstructured":"Maffucci P, Filion CA, Boisson B, Itan Y, Shang L, Casanova JL, et al. Genetic diagnosis using whole exome sequencing in common variable immunodeficiency. Front Immunol. 2016;7:220.","journal-title":"Front Immunol"},{"key":"415_CR11","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.jaci.2014.11.029","volume":"135","author":"C Wehr","year":"2015","unstructured":"Wehr C, Gennery AR, Lindemans C, Schulz A, Hoenig M, Marks R, et al. Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency. J Allergy Clin Immunol. 2015;135:988\u201397. e6","journal-title":"J Allergy Clin Immunol"},{"key":"415_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","volume":"111","author":"C Wehr","year":"2008","unstructured":"Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood. 2008;111:77\u201385.","journal-title":"Blood"},{"key":"415_CR13","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1007\/s10875-010-9424-3","volume":"30","author":"G Mouillot","year":"2010","unstructured":"Mouillot G, Carmagnat M, Gerard L, Garnier JL, Fieschi C, Vince N, et al. B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease. J Clin Immunol. 2010;30:746\u201355.","journal-title":"J Clin Immunol"},{"key":"415_CR14","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1111\/j.1399-3038.2010.01004.x","volume":"21","author":"PL Yong","year":"2010","unstructured":"Yong PL, Orange JS, Sullivan KE. Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells. Pediatr Allergy Immunol. 2010;21:852\u20138.","journal-title":"Pediatr Allergy Immunol"},{"issue":"6","key":"415_CR15","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1162\/neco.2007.19.6.1503","volume":"19","author":"Hideaki Shimazaki","year":"2007","unstructured":"Shimazaki H, Shinomoto S. A method for selecting the bin size of a time histogram. Neural Comput. 2007;19(6):1503\u201327.","journal-title":"Neural Computation"},{"key":"415_CR16","first-page":"S89","volume":"34","author":"KD Jones","year":"2016","unstructured":"Jones KD, Gelbart T, Whisenant TC, Waalen J, Mondala TS, Ikle DN, et al. Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia. Clin Exp Rheumatol. 2016;34:S89\u201398.","journal-title":"Clin Exp Rheumatol"},{"key":"415_CR17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1542\/peds.37.5.715","volume":"37","author":"ER Stiehm","year":"1966","unstructured":"Stiehm ER, Fudenberg HH. Serum levels of immune globulin in health and disease. A survey. Pediatrics. 1966;37:715.","journal-title":"Pediatrics"},{"issue":"6","key":"415_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0167-5699(92)90157-3","volume":"13","author":"I Hannet","year":"1992","unstructured":"Hannet I, Erkeller-Yuksel F, Lydyard P, Deneys V, DeBruyere M. Developmental and maturational changes in the human blood lymphocyte subpopulations. Immunol Today. 1992;13(6):215\u20138.","journal-title":"Immunol Today"},{"issue":"5","key":"415_CR19","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jaci.2003.07.003","volume":"112","author":"William T. Shearer","year":"2003","unstructured":"Shearer WT, Rosenblatt HM, Gelman RS, Oyomopito R, Plaeger S et al. Lymphocyte subsets in healthy children from birth through 18 years of age: the pediatric AIDS clinical trials P1009 study. J All Clin Immunol 112(5);973\u2013980.","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"415_CR20","first-page":"95","volume":"45","author":"AJ Duarte","year":"1990","unstructured":"Duarte AJ, Vasconcelos DM, Sato MN, Sales JM, Yamaguchi NH, et al. Common variable immunodeficiency (hypogammaglobulinemia of late onset or acquired hypogammaglobulinemia): initial follow up of 11 cases. Rev Hosp Clin. 1990;45:95\u2013104.","journal-title":"Rev Hosp Clin"},{"key":"415_CR21","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1086\/606059","volume":"49","author":"M Malphettes","year":"2009","unstructured":"Malphettes M, Gerard L, Carmagnat M, Mouillot G, Vince N, et al. Late-onset common variable immune deficiency: a subset of common variable immunodeficiency with severe t cell defect. Clin Inf Dis. 2009;49:1329\u201338.","journal-title":"Clin Inf Dis"},{"key":"415_CR22","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/acr.22639","volume":"68","author":"E Iacob","year":"2016","unstructured":"Iacob E, Light AR, Donaldson GW, Okifuji A, Hughen RW, White AT, et al. Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample. Arthritis Care Res (Hoboken). 2016;68:132\u201340.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"415_CR23","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3389\/fimmu.2014.00605","volume":"5","author":"S Tabolli","year":"2014","unstructured":"Tabolli S, Giannantoni P, Pulvirenti F, La Marra F, Granata G, Milito C, et al. Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies. Front Immunol. 2014;5:605.","journal-title":"Front Immunol"},{"key":"415_CR24","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3349\/ymj.2012.53.3.603","volume":"53","author":"I Quinti","year":"2012","unstructured":"Quinti I, Di Pietro C, Martini H, Pesce AM, Lombardi F, Baumghartner M, et al. Health related quality of life in common variable immunodeficiency. Yonsei Med J. 2012;53:603\u201310.","journal-title":"Yonsei Med J"},{"issue":"6","key":"415_CR25","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1542\/peds.2010-2989","volume":"127","author":"CA Boyle","year":"2011","unstructured":"Boyle CA, Boulet S, Schieve LA, Cohen RA, Blumberg SJ, et al. Trends in the prevalence of developmental disabilities in US children, 1997-2008. Pediatrics. 2011;127(6):1034\u201342.","journal-title":"Pediatrics"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-017-0415-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-017-0415-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-017-0415-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T15:43:04Z","timestamp":1659282184000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-017-0415-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["415"],"URL":"https:\/\/doi.org\/10.1007\/s10875-017-0415-5","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]},"assertion":[{"value":"9 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Supported in part by NIH U24AI086037 and the Wallace Chair of Pediatrics (KES). The authors gratefully acknowledge the support of USIDNET by Baxalta and the Immune Deficiency Foundation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding Sources"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}