{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:41:29Z","timestamp":1786981289291,"version":"build-2736575974"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s10875-019-00663-y","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T07:04:31Z","timestamp":1562051071000},"page":"592-595","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Compound Heterozygous DOCK8 Mutations in a Patient with B Lymphoblastic Leukemia and EBV-Associated Diffuse Large B Cell Lymphoma"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-3473","authenticated-orcid":false,"given":"David","family":"Buchbinder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Kirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Danielson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirali N.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra F.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishikesh S.","family":"Chavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen C.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"issue":"21","key":"663_CR1","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","volume":"361","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Davis JC, Lamborn IT, Freeman AF, Jing H, Favreau AJ, et al. Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med. 2009;361(21):2046\u201355.","journal-title":"N Engl J Med"},{"issue":"3","key":"663_CR2","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.jaci.2012.12.1568","volume":"131","author":"MC Mizesko","year":"2013","unstructured":"Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, et al. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2013;131(3):840\u20138.","journal-title":"J Allergy Clin Immunol"},{"issue":"13","key":"663_CR3","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1084\/jem.20141307","volume":"211","author":"Q Zhang","year":"2014","unstructured":"Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, et al. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. J Exp Med. 2014;211(13):2549\u201366.","journal-title":"J Exp Med"},{"issue":"12","key":"663_CR4","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1002\/eji.201141759","volume":"41","author":"T Lambe","year":"2011","unstructured":"Lambe T, Crawford G, Johnson A, et al. DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol. 2011;41(12):3423\u201335.","journal-title":"Eur J Immunol"},{"issue":"2","key":"663_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10875-014-0126-0","volume":"35","author":"SE Aydin","year":"2015","unstructured":"Aydin SE, Kilic SS, Aytekin C, et al. DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. J Clin Immunol. 2015;35(2):189\u201398.","journal-title":"J Clin Immunol"},{"issue":"2","key":"663_CR6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.jaci.2014.12.1945","volume":"136","author":"KR Engelhardt","year":"2015","unstructured":"Engelhardt KR, Gertz ME, Keles S, Sch\u00e4ffer AA, Sigmund EC, Glocker C, et al. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015;136(2):402\u201312.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"663_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/imr.12723","volume":"287","author":"HC Su","year":"2019","unstructured":"Su HC, Jing H, Angelus P, Freeman AF. Insights into immunity from clinical and basic science studies of DOCK8 immunodeficiency syndrome. Immunol Rev. 2019;287(1):9\u201319.","journal-title":"Immunol Rev"},{"issue":"5","key":"663_CR8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s10875-016-0296-z","volume":"36","author":"Q Zhang","year":"2016","unstructured":"Zhang Q, Jing H, Su HC. Recent advances in DOCK8 immunodeficiency syndrome. J Clin Immunol. 2016;36(5):441\u20139.","journal-title":"J Clin Immunol"},{"issue":"1","key":"663_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jaci.2014.02.023","volume":"134","author":"SY Pai","year":"2014","unstructured":"Pai SY, de Boer H, Massaad MJ, Chatila TA, Keles S, Jabara HH, et al. Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. J Allergy Clin Immunol. 2014;134(1):221\u20133.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"663_CR10","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.bbmt.2017.03.016","volume":"23","author":"NN Shah","year":"2017","unstructured":"Shah NN, Freeman AF, Su H, Cole K, Parta M, Moutsopoulos NM, et al. Haploidentical related donor hematopoietic stem cell transplantation for dedicator-of-cytokinesis 8 deficiency using post-transplantation cyclophosphamide. Biol Blood Marrow Transplant. 2017;23(6):980\u201390.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"663_CR11","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.jaip.2018.10.035","volume":"7","author":"SE Aydin","year":"2019","unstructured":"Aydin SE, Freeman AF, Al-Herz W, et al. Hematopoietic stem cell transplantation as treatment for patients with DOCK8 deficiency. J Allergy Clin Immunol Pract. 2019;7(3):848\u201355.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"6","key":"663_CR12","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.jaci.2014.03.025","volume":"133","author":"H Jing","year":"2014","unstructured":"Jing H, Zhang Q, Zhang Y, Hill BJ, Dove CG, Gelfand EW, et al. Somatic reversion in DOCK8 immunodeficiency modulates disease phenotypes. J Allergy Clin Immunol. 2014;133(6):1667\u201375.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-019-00663-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-019-00663-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-019-00663-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T20:08:10Z","timestamp":1593547690000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-019-00663-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["663"],"URL":"https:\/\/doi.org\/10.1007\/s10875-019-00663-y","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]},"assertion":[{"value":"28 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declared that have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}