{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:17:38Z","timestamp":1770538658126,"version":"3.49.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004006","name":"Bilimsel Ara\u015ftirma Projeleri Birimi, Istanbul \u00dcniversitesi","doi-asserted-by":"crossref","award":["TOA 20499"],"award-info":[{"award-number":["TOA 20499"]}],"id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bilgi University","award":["2018.01.006"],"award-info":[{"award-number":["2018.01.006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s10875-020-00816-4","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T18:03:01Z","timestamp":1593799381000},"page":"883-892","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lymphoma Predisposing Gene in an Extended Family: CD70 Signaling Defect"],"prefix":"10.1007","volume":"40","author":[{"given":"Khusan","family":"Khodzhaev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema Buyukkapu","family":"Bay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-8174","authenticated-orcid":false,"given":"Rejin","family":"Kebudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didem","family":"Altindirek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysenur","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucel","family":"Erbilgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozden Hatirnaz","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayca","family":"Kiykim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda Cipe","family":"Erol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feride Sen","family":"Zengin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinem","family":"Firtina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuk Yin","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basak Adakli","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muge","family":"Sayitoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,3]]},"reference":[{"issue":"4","key":"816_CR1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/ajmg.a.38142","volume":"173","author":"T Ripperger","year":"2017","unstructured":"Ripperger T, Bielack SS, Borkhardt A, Brecht IB, Burkhardt B, Calaminus G, et al. Childhood cancer predisposition syndromes-a concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology. Am J Med Genet A. 2017;173(4):1017\u201337.","journal-title":"Am J Med Genet A"},{"issue":"5","key":"816_CR2","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1172\/JCI37901","volume":"119","author":"K Huck","year":"2009","unstructured":"Huck K, Feyen O, Niehues T, R\u00fcschendorf F, H\u00fcbner N, Laws HJ, et al. Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest. 2009;119(5):1350\u20138.","journal-title":"J Clin Invest"},{"issue":"5","key":"816_CR3","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/leu.2011.371","volume":"26","author":"RM Linka","year":"2012","unstructured":"Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, et al. Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases. Leukemia. 2012;26(5):963\u201371.","journal-title":"Leukemia"},{"issue":"1","key":"816_CR4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/bmt.2016.185","volume":"52","author":"D Cagdas","year":"2017","unstructured":"Cagdas D, et al. Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow transplantation in one sibling; and death in the other. Bone Marrow Transplant. 2017;52(1):126\u20139.","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"816_CR5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1182\/blood-2010-06-284935","volume":"117","author":"C Booth","year":"2011","unstructured":"Booth C, Gilmour KC, Veys P, Gennery AR, Slatter MA, Chapel H, et al. X-linked lymphoproliferative disease due to SAP\/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease. Blood. 2011;117(1):53\u201362.","journal-title":"Blood"},{"issue":"7357","key":"816_CR6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature10246","volume":"475","author":"FY Li","year":"2011","unstructured":"Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, et al. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature. 2011;475(7357):471\u20136.","journal-title":"Nature"},{"issue":"6142","key":"816_CR7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1240094","volume":"341","author":"B Chaigne-Delalande","year":"2013","unstructured":"Chaigne-Delalande B, Li FY, O\u2019Connor GM, Lukacs MJ, Jiang P, Zheng L, et al. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science. 2013;341(6142):186\u201391.","journal-title":"Science"},{"issue":"1","key":"816_CR8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.clim.2015.04.015","volume":"159","author":"T Patiroglu","year":"2015","unstructured":"Patiroglu T, Haluk Akar H, Gilmour K, Unal E, Akif Ozdemir M, Bibi S, et al. A case of XMEN syndrome presented with severe auto-immune disorders mimicking autoimmune lymphoproliferative disease. Clin Immunol. 2015;159(1):58\u201362.","journal-title":"Clin Immunol"},{"issue":"7504","key":"816_CR9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature13386","volume":"510","author":"E Martin","year":"2014","unstructured":"Martin E, Palmic N, Sanquer S, Lenoir C, Hauck F, Mongellaz C, et al. CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation. Nature. 2014;510(7504):288\u201392.","journal-title":"Nature"},{"issue":"3","key":"816_CR10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jaci.2015.02.022","volume":"136","author":"OK Alkhairy","year":"2015","unstructured":"Alkhairy OK, Perez-Becker R, Driessen GJ, Abolhassani H, van Montfrans J, Borte S, et al. Novel mutations in TNFRSF7\/CD27: clinical, immunologic, and genetic characterization of human CD27 deficiency. J Allergy Clin Immunol. 2015;136(3):703\u201312 e10.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"816_CR11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20160849","volume":"214","author":"H Abolhassani","year":"2017","unstructured":"Abolhassani H, Edwards ESJ, Ikinciogullari A, Jing H, Borte S, Buggert M, et al. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. J Exp Med. 2017;214(1):91\u2013106.","journal-title":"J Exp Med"},{"key":"816_CR12","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3389\/fimmu.2017.02015","volume":"8","author":"R Caorsi","year":"2017","unstructured":"Caorsi R, et al. CD70 deficiency due to a novel mutation in a patient with severe chronic EBV infection presenting as a periodic fever. Front Immunol. 2017;8:2015.","journal-title":"Front Immunol"},{"issue":"1","key":"816_CR13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1084\/jem.20160784","volume":"214","author":"K Izawa","year":"2017","unstructured":"Izawa K, Martin E, Soudais C, Bruneau J, Boutboul D, Rodriguez R, et al. Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection. J Exp Med. 2017;214(1):73\u201389.","journal-title":"J Exp Med"},{"issue":"6","key":"816_CR14","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.jaci.2013.01.042","volume":"131","author":"D Moshous","year":"2013","unstructured":"Moshous D, Martin E, Carpentier W, Lim A, Callebaut I, Canioni D, et al. Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation. J Allergy Clin Immunol. 2013;131(6):1594\u2013603.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"816_CR15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s10875-015-0130-z","volume":"35","author":"D Punwani","year":"2015","unstructured":"Punwani D, Pelz B, Yu J, Arva NC, Schafernak K, Kondratowicz K, et al. Coronin-1A: immune deficiency in humans and mice. J Clin Immunol. 2015;35(2):100\u20137.","journal-title":"J Clin Immunol"},{"issue":"12","key":"816_CR16","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/ni.3575","volume":"17","author":"E Salzer","year":"2016","unstructured":"Salzer E, Cagdas D, Hons M, Mace EM, Garncarz W, Petronczki \u00d6Y, et al. RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nat Immunol. 2016;17(12):1352\u201360.","journal-title":"Nat Immunol"},{"key":"816_CR17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.clim.2017.08.007","volume":"183","author":"CD Platt","year":"2017","unstructured":"Platt CD, Fried AJ, Hoyos-Bachiloglu R, Usmani GN, Schmidt B, Whangbo J, et al. Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. Clin Immunol. 2017;183:142\u20134.","journal-title":"Clin Immunol"},{"issue":"2","key":"816_CR18","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jaci.2019.03.002","volume":"144","author":"MF Alosaimi","year":"2019","unstructured":"Alosaimi MF, Hoenig M, Jaber F, Platt CD, Jones J, Wallace J, et al. Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. J Allergy Clin Immunol. 2019;144(2):574\u201383 e5.","journal-title":"J Allergy Clin Immunol"},{"issue":"15","key":"816_CR19","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1182\/blood-2011-09-378158","volume":"119","author":"H Abdollahpour","year":"2012","unstructured":"Abdollahpour H, Appaswamy G, Kotlarz D, Diestelhorst J, Beier R, Sch\u00e4ffer AA, et al. The phenotype of human STK4 deficiency. Blood. 2012;119(15):3450\u20137.","journal-title":"Blood"},{"issue":"48","key":"816_CR20","doi-asserted-by":"crossref","first-page":"e8852","DOI":"10.1097\/MD.0000000000008852","volume":"96","author":"R Sherkat","year":"2017","unstructured":"Sherkat R, Sabri MR, Dehghan B, Bigdelian H, Reisi N, Afsharmoghadam N, et al. EBV lymphoproliferative-associated disease and primary cardiac T-cell lymphoma in a STK4 deficient patient: a case report. Medicine (Baltimore). 2017;96(48):e8852.","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"816_CR21","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1182\/blood-2017-02-768234","volume":"130","author":"J Park","year":"2017","unstructured":"Park J, Yang J, Wenzel AT, Ramachandran A, Lee WJ, Daniels JC, et al. Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood. 2017;130(12):1430\u201340.","journal-title":"Blood"},{"issue":"11","key":"816_CR22","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1084\/jem.20160576","volume":"213","author":"Y Wang","year":"2016","unstructured":"Wang Y, Ma CS, Ling Y, Bousfiha A, Camcioglu Y, Jacquot S, et al. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med. 2016;213(11):2413\u201335.","journal-title":"J Exp Med"},{"key":"816_CR23","doi-asserted-by":"crossref","unstructured":"Uchida Y, Yoshimitsu M, Kamada Y, Arima N, Ishitsuka K. A novel recurrent gain-of-function mutation of Rltpr Q575E in adult T cell leukemia\/lymphoma. 2019;134(Supplement_1):1489 Ash Publications.","DOI":"10.1182\/blood-2019-124641"},{"issue":"16","key":"816_CR24","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1182\/blood-2012-12-469544","volume":"121","author":"HS Kuehn","year":"2013","unstructured":"Kuehn HS, Niemela JE, Rangel-Santos A, Zhang M, Pittaluga S, Stoddard JL, et al. Loss-of-function of the protein kinase C delta (PKCdelta) causes a B-cell lymphoproliferative syndrome in humans. Blood. 2013;121(16):3117\u201325.","journal-title":"Blood"},{"issue":"16","key":"816_CR25","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1182\/blood-2012-10-460741","volume":"121","author":"E Salzer","year":"2013","unstructured":"Salzer E, Santos-Valente E, Klaver S, Ban SA, Emminger W, Prengemann NK, et al. B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C delta. Blood. 2013;121(16):3112\u20136.","journal-title":"Blood"},{"issue":"1","key":"816_CR26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10875-020-00758-x","volume":"40","author":"A Bousfiha","year":"2020","unstructured":"Bousfiha A, Jeddane L, Picard C, al-Herz W, Ailal F, Chatila T, et al. Human inborn errors of immunity: 2019 update of the IUIS phenotypical classification. J Clin Immunol. 2020;40(1):66\u201381.","journal-title":"J Clin Immunol"},{"key":"816_CR27","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3389\/fimmu.2018.01103","volume":"9","author":"S Latour","year":"2018","unstructured":"Latour S, Winter S. Inherited immunodeficiencies with high predisposition to Epstein-Barr virus-driven lymphoproliferative diseases. Front Immunol. 2018;9:1103.","journal-title":"Front Immunol"},{"issue":"6\u20137","key":"816_CR28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00439-020-02145-3","volume":"139","author":"SG Tangye","year":"2020","unstructured":"Tangye SG. Genetic susceptibility to EBV infection: insights from inborn errors of immunity. Hum Genet. 2020;139(6\u20137):885\u2013901.","journal-title":"Hum Genet"},{"issue":"9","key":"816_CR29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1182\/blood.2019000928","volume":"135","author":"SG Tangye","year":"2020","unstructured":"Tangye SG, Latour S. Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection. Blood. 2020;135(9):644\u201355.","journal-title":"Blood"},{"issue":"3","key":"816_CR30","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0092-8674(93)90133-B","volume":"73","author":"RG Goodwin","year":"1993","unstructured":"Goodwin RG, Alderson MR, Smith CA, Armitage RJ, VandenBos T, Jerzy R, et al. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Cell. 1993;73(3):447\u201356.","journal-title":"Cell"},{"issue":"4","key":"816_CR31","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.4049\/jimmunol.152.4.1756","volume":"152","author":"MR Bowman","year":"1994","unstructured":"Bowman MR, et al. The cloning of CD70 and its identification as the ligand for CD27. J Immunol. 1994;152(4):1756\u201361.","journal-title":"J Immunol"},{"issue":"10","key":"816_CR32","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1002\/eji.1830231037","volume":"23","author":"RG Goodwin","year":"1993","unstructured":"Goodwin RG, Din WS, Davis-Smith T, Anderson DM, Gimpel SD, Sato TA, et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol. 1993;23(10):2631\u201341.","journal-title":"Eur J Immunol"},{"issue":"8","key":"816_CR33","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.4049\/jimmunol.154.8.3686","volume":"154","author":"GR Brown","year":"1995","unstructured":"Brown GR, et al. CD27-CD27 ligand\/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes. J Immunol. 1995;154(8):3686\u201395.","journal-title":"J Immunol"},{"issue":"6","key":"816_CR34","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.154.6.2612","volume":"154","author":"RQ Hintzen","year":"1995","unstructured":"Hintzen RQ, et al. Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation. J Immunol. 1995;154(6):2612\u201323.","journal-title":"J Immunol"},{"issue":"5","key":"816_CR35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/80877","volume":"1","author":"J Hendriks","year":"2000","unstructured":"Hendriks J, Gravestein LA, Tesselaar K, van Lier RAW, Schumacher TNM, Borst J. CD27 is required for generation and long-term maintenance of T cell immunity. Nat Immunol. 2000;1(5):433\u201340.","journal-title":"Nat Immunol"},{"issue":"5","key":"816_CR36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1074-7613(01)00236-9","volume":"15","author":"R Arens","year":"2001","unstructured":"Arens R, Tesselaar K, Baars PA, van Schijndel GMW, Hendriks J, Pals ST, et al. Constitutive CD27\/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. Immunity. 2001;15(5):801\u201312.","journal-title":"Immunity"},{"issue":"3","key":"816_CR37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jaci.2011.11.013","volume":"129","author":"JM van Montfrans","year":"2012","unstructured":"van Montfrans JM, Hoepelman AIM, Otto S, van Gijn M, van de Corput L, de Weger RA, et al. CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. J Allergy Clin Immunol. 2012;129(3):787\u201393 e6.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"816_CR38","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1600-065X.2009.00774.x","volume":"229","author":"MA Nolte","year":"2009","unstructured":"Nolte MA, van Olffen RW, van Gisbergen KPJM, van Lier RAW. Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol Rev. 2009;229(1):216\u201331.","journal-title":"Immunol Rev"},{"issue":"4","key":"816_CR39","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nri2526","volume":"9","author":"M Croft","year":"2009","unstructured":"Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol. 2009;9(4):271\u201385.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"816_CR40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2141.1999.01573.x","volume":"106","author":"SM Lens","year":"1999","unstructured":"Lens SM, et al. Aberrant expression and reverse signalling of CD70 on malignant B cells. Br J Haematol. 1999;106(2):491\u2013503.","journal-title":"Br J Haematol"},{"issue":"12","key":"816_CR41","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1182\/blood.V85.12.3556.bloodjournal85123556","volume":"85","author":"EA Ranheim","year":"1995","unstructured":"Ranheim EA, Cantwell MJ, Kipps TJ. Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells. Blood. 1995;85(12):3556\u201365.","journal-title":"Blood"},{"issue":"23","key":"816_CR42","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1158\/1078-0432.CCR-08-0493","volume":"14","author":"JA McEarchern","year":"2008","unstructured":"McEarchern JA, Smith LM, McDonagh CF, Klussman K, Gordon KA, Morris-Tilden CA, et al. Preclinical characterization of SGN-70, a humanized antibody directed against CD70. Clin Cancer Res. 2008;14(23):7763\u201372.","journal-title":"Clin Cancer Res"},{"key":"816_CR43","doi-asserted-by":"crossref","unstructured":"Rejin Kebudi SBB, Gorgun O, Agaoglu FY, Zulfikar B, Ayan I, Iribas A, et al. Risk adapted treatment in childhood Hodgkin\u2019s lymphoma: outcome and changing epidemiologic features in 25 years. Blood. 2016;128(22).","DOI":"10.1182\/blood.V128.22.4158.4158"},{"issue":"10","key":"816_CR44","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00251-017-1005-7","volume":"69","author":"S Firtina","year":"2017","unstructured":"Firtina S, Ng YY, Ng OH, Nepesov S, Yesilbas O, Kilercik M, et al. A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey. Immunogenetics. 2017;69(10):653\u20139.","journal-title":"Immunogenetics"},{"issue":"10","key":"816_CR45","doi-asserted-by":"crossref","first-page":"e1003876","DOI":"10.1371\/journal.pgen.1003876","volume":"9","author":"AE Gylfe","year":"2013","unstructured":"Gylfe AE, Katainen R, Kondelin J, Tanskanen T, Cajuso T, H\u00e4nninen U, et al. Eleven candidate susceptibility genes for common familial colorectal cancer. PLoS Genet. 2013;9(10):e1003876.","journal-title":"PLoS Genet"},{"issue":"3","key":"816_CR46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ajhg.2017.07.016","volume":"101","author":"DR Krupp","year":"2017","unstructured":"Krupp DR, Barnard RA, Duffourd Y, Evans SA, Mulqueen RM, Bernier R, et al. Exonic mosaic mutations contribute risk for autism spectrum disorder. Am J Hum Genet. 2017;101(3):369\u201390.","journal-title":"Am J Hum Genet"},{"key":"816_CR47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fimmu.2016.00365","volume":"7","author":"E Mortaz","year":"2016","unstructured":"Mortaz E, et al. Cancers related to immunodeficiencies: update and perspectives. Front Immunol. 2016;7:365.","journal-title":"Front Immunol"},{"issue":"4","key":"816_CR48","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.leukres.2015.02.002","volume":"39","author":"S Gangemi","year":"2015","unstructured":"Gangemi S, Allegra A, Musolino C. Lymphoproliferative disease and cancer among patients with common variable immunodeficiency. Leuk Res. 2015;39(4):389\u201396.","journal-title":"Leuk Res"},{"issue":"2","key":"816_CR49","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clim.2014.10.003","volume":"156","author":"BM Jonkman-Berk","year":"2015","unstructured":"Jonkman-Berk BM, van den Berg JM, ten Berge IJM, Bredius RGM, Driessen GJ, Dalm VASH, et al. Primary immunodeficiencies in the Netherlands: national patient data demonstrate the increased risk of malignancy. Clin Immunol. 2015;156(2):154\u201362.","journal-title":"Clin Immunol"},{"issue":"19 Suppl","key":"816_CR50","first-page":"5465s","volume":"52","author":"AH Filipovich","year":"1992","unstructured":"Filipovich AH, et al. Primary immunodeficiencies: genetic risk factors for lymphoma. Cancer Res. 1992;52(19 Suppl):5465s\u20137s.","journal-title":"Cancer Res"},{"issue":"3","key":"816_CR51","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jaci.2017.05.024","volume":"141","author":"PC Mayor","year":"2018","unstructured":"Mayor PC, Eng KH, Singel KL, Abrams SI, Odunsi K, Moysich KB, et al. Cancer in primary immunodeficiency diseases: cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol. 2018;141(3):1028\u201335.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"816_CR52","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/1573396315666190917154058","volume":"15","author":"R Kebudi","year":"2019","unstructured":"Kebudi R, Kiykim A, Sahin MK. Primary immunodeficiency and cancer in children; a review of the literature. Curr Pediatr Rev. 2019;15(4):245\u201350.","journal-title":"Curr Pediatr Rev"},{"issue":"3","key":"816_CR53","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.coi.2005.04.004","volume":"17","author":"J Borst","year":"2005","unstructured":"Borst J, Hendriks J, Xiao Y. CD27 and CD70 in T cell and B cell activation. Curr Opin Immunol. 2005;17(3):275\u201381.","journal-title":"Curr Opin Immunol"},{"issue":"2","key":"816_CR54","first-page":"e2009013","volume":"1","author":"G Massini","year":"2009","unstructured":"Massini G, Siemer D, Hohaus S. EBV in Hodgkin lymphoma. Mediterr J Hematol Infect Dis. 2009;1(2):e2009013.","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"12","key":"816_CR55","first-page":"591","volume":"33","author":"M Vockerodt","year":"2014","unstructured":"Vockerodt M, Cader FZ, Shannon-Lowe C, Murray P. Epstein-Barr virus and the origin of Hodgkin lymphoma. Chin J Cancer. 2014;33(12):591\u20137.","journal-title":"Chin J Cancer"},{"key":"816_CR56","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1479-5876-11-119","volume":"11","author":"F Serana","year":"2013","unstructured":"Serana F, Chiarini M, Zanotti C, Sottini A, Bertoli D, Bosio A, et al. Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies. J Transl Med. 2013;11:119.","journal-title":"J Transl Med"},{"issue":"8","key":"816_CR57","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/gcc.22072","volume":"52","author":"P Bertrand","year":"2013","unstructured":"Bertrand P, Maingonnat C, Penther D, Guney S, Ruminy P, Picquenot JM, et al. The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma. Genes Chromosom Cancer. 2013;52(8):764\u201374.","journal-title":"Genes Chromosom Cancer"},{"issue":"6","key":"816_CR58","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1365-2141.2008.07262.x","volume":"142","author":"M Giefing","year":"2008","unstructured":"Giefing M, Arnemann J, Martin-Subero JI, Niel\u00e4nder I, Bug S, Hartmann S, et al. Identification of candidate tumour suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterisation of homozygous deletions in classical Hodgkin lymphoma cell lines. Br J Haematol. 2008;142(6):916\u201324.","journal-title":"Br J Haematol"},{"issue":"5","key":"816_CR59","doi-asserted-by":"crossref","first-page":"E830","DOI":"10.1002\/ijc.27416","volume":"131","author":"R Scholtysik","year":"2012","unstructured":"Scholtysik R, Nagel I, Kreuz M, Vater I, Giefing M, Schwaenen C, et al. Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas. Int J Cancer. 2012;131(5):E830\u20135.","journal-title":"Int J Cancer"},{"issue":"3","key":"816_CR60","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1158\/1055-9965.EPI-06-1070","volume":"16","author":"AE Grulich","year":"2007","unstructured":"Grulich AE, Vajdic CM, Cozen W. Altered immunity as a risk factor for non-Hodgkin lymphoma. Cancer Epidemiol Biomark Prev. 2007;16(3):405\u20138.","journal-title":"Cancer Epidemiol Biomark Prev"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-020-00816-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-020-00816-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-020-00816-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:27:24Z","timestamp":1696332444000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-020-00816-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,3]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["816"],"URL":"https:\/\/doi.org\/10.1007\/s10875-020-00816-4","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,3]]},"assertion":[{"value":"18 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}