{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:10:00Z","timestamp":1782781800145,"version":"3.54.5"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC No. 81872539"],"award-info":[{"award-number":["NSFC No. 81872539"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010896","name":"International Cooperation and Exchange Programme","doi-asserted-by":"publisher","award":["NSFC No. 81520108026"],"award-info":[{"award-number":["NSFC No. 81520108026"]}],"id":[{"id":"10.13039\/501100010896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s10875-020-00909-0","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T15:04:38Z","timestamp":1605193478000},"page":"427-440","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Primary Cutaneous Aspergillosis in a Patient with CARD9 Deficiency and Aspergillus Susceptibility of Card9 Knockout Mice"],"prefix":"10.1007","volume":"41","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinggai","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1451-3598","authenticated-orcid":false,"given":"Ruoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"issue":"26","key":"909_CR1","doi-asserted-by":"publisher","first-page":"e3747","DOI":"10.1097\/MD.0000000000003747","volume":"95","author":"AM Tatara","year":"2016","unstructured":"Tatara AM, Mikos AG, Kontoyiannis DP. Factors affecting patient outcome in primary cutaneous aspergillosis. Medicine (Baltimore). 2016;95(26):e3747.","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"909_CR2","first-page":"839","volume":"15","author":"S Darr-Foit","year":"2017","unstructured":"Darr-Foit S, Schliemann S, Scholl S, Hipler UC, Elsner P. Primary cutaneous aspergillosis - an uncommon opportunistic infection review of the literature and case presentation. J Dtsch Dermatol Ges. 2017;15(8):839\u201341.","journal-title":"J Dtsch Dermatol Ges"},{"issue":"48","key":"909_CR3","doi-asserted-by":"publisher","first-page":"e8916","DOI":"10.1097\/MD.0000000000008916","volume":"96","author":"X Liu","year":"2017","unstructured":"Liu X, Yang J, Ma W. Primary cutaneous aspergillosis caused by Aspergillus fumigatus in an immunocompetent patient. Medicine (Baltimore). 2017;96(48):e8916.","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"909_CR4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41419-017-0084-6","volume":"9","author":"X Zhong","year":"2018","unstructured":"Zhong X, Chen B, Yang L, Yang Z. Molecular and physiological roles of the adaptor protein CARD9 in immunity. Cell Death Dis. 2018;9(2):52.","journal-title":"Cell Death Dis"},{"issue":"6","key":"909_CR5","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1007\/s10875-018-0539-2","volume":"38","author":"E Corvilain","year":"2018","unstructured":"Corvilain E, Casanova J-L, Puel A. Inherited CARD9 deficiency: invasive disease caused by ascomycete fungi in previously healthy children and adults. J Clin Immunol. 2018;38(6):656\u201393.","journal-title":"J Clin Immunol"},{"issue":"10","key":"909_CR6","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/myc.12962","volume":"62","author":"C Huang","year":"2019","unstructured":"Huang C, Zhang Y, Song Y, Wan Z, Wang X, Li R. Phaeohyphomycosis caused by Phialophora americana with CARD9 mutation and 20-year literature review in China. Mycoses. 2019;62(10):908\u201319.","journal-title":"Mycoses."},{"issue":"9\u201310","key":"909_CR7","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s11046-016-0029-0","volume":"181","author":"W Wu","year":"2016","unstructured":"Wu W, Zhang R, Wang X, Song Y, Liu Z, Han W, et al. Impairment of immune response against dematiaceous fungi in Card9 knockout mice. Mycopathologia. 2016;181(9\u201310):631\u201342.","journal-title":"Mycopathologia."},{"issue":"11","key":"909_CR8","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nrmicro.2017.90","volume":"15","author":"FL van de Veerdonk","year":"2017","unstructured":"van de Veerdonk FL, Gresnigt MS, Romani L, Netea MG, Latg\u00e9 JP. Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol. 2017;15(11):661\u201374.","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"909_CR9","doi-asserted-by":"publisher","first-page":"408","DOI":"10.4103\/ijccm.IJCCM_18_17","volume":"21","author":"M Kartik","year":"2017","unstructured":"Kartik M, Kanala A, Sunilnadikuda, Rao SM, Prakasham PS. Invasive mediastinal Aspergillosis in immunocompetent male with invasion of left atrium and hilar structures. Indian J Crit Care Med. 2017;21(6):408\u201311.","journal-title":"Indian J Crit Care Med"},{"issue":"1","key":"909_CR10","doi-asserted-by":"publisher","first-page":"e00140","DOI":"10.1128\/CMR.00140-18","volume":"33","author":"JP Latg\u00e9","year":"2019","unstructured":"Latg\u00e9 JP, Chamilos G. Aspergillus fumigatus and Aspergillosis in 2019. Clin Microbiol Rev. 2019;33(1):e00140\u201318.","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"909_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.mmcr.2012.09.004","volume":"1","author":"TV Venugopal","year":"2012","unstructured":"Venugopal TV, Venugopal PV. Primary cutaneous aspergillosis from Tamilnadu diagnosed by fine needle aspiration cytology. Med Mycol Case Rep. 2012;1(1):103\u20136.","journal-title":"Med Mycol Case Rep"},{"issue":"26","key":"909_CR12","doi-asserted-by":"publisher","first-page":"e1018","DOI":"10.1097\/MD.0000000000001018","volume":"94","author":"C Bernardeschi","year":"2015","unstructured":"Bernardeschi C, Foulet F, Ingen-Housz-Oro S, Ortonne N, Sitbon K, Quereux G, et al. Cutaneous invasive aspergillosis: retrospective multicenter study of the French invasive-aspergillosis registry and literature review. Medicine (Baltimore). 2015;94(26):e1018.","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"909_CR13","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/DAD.0b013e31829cc6f3","volume":"36","author":"A Fernandez-Flores","year":"2014","unstructured":"Fernandez-Flores A, Saeb-Lima M, Arenas-Guzman R. Morphological findings of deep cutaneous fungal infections. Am J Dermatopathol. 2014;36(7):531\u201353 quiz 554\u20136.","journal-title":"Am J Dermatopathol"},{"issue":"4","key":"909_CR14","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.jaad.2018.04.059","volume":"80","author":"BE Shields","year":"2019","unstructured":"Shields BE, Rosenbach M, Brown-Joel Z, Berger AP, Ford BA, Wanat KA. Angioinvasive fungal infections impacting the skin: background, epidemiology, and clinical presentation. J Am Acad Dermatol. 2019;80(4):869\u201380.e5.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"909_CR15","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1186\/s12879-017-2646-8","volume":"17","author":"F Gallais","year":"2017","unstructured":"Gallais F, Denis J, Koobar O, Dillenseger L, Astruc D, Herbrecht R, et al. Simultaneous primary invasive cutaneous aspergillosis in two preterm twins: case report and review of the literature. BMC Infect Dis. 2017;17(1):535.","journal-title":"BMC Infect Dis"},{"issue":"5","key":"909_CR16","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1093\/mmy\/myv004","volume":"53","author":"S Challa","year":"2015","unstructured":"Challa S, Uppin SG, Uppin MS, Pamidimukkala U, Vemu L. Diagnosis of filamentous fungi on tissue sections by immunohistochemistry using anti-aspergillus antibody. Med Mycol. 2015;53(5):470\u20136.","journal-title":"Med Mycol"},{"issue":"11","key":"909_CR17","first-page":"1664","volume":"61","author":"J Jung","year":"2015","unstructured":"Jung J, Park YS, Sung H, Song JS, Lee S-O, Choi S-H, et al. Using of immunohistochemistry to assess the accuracy of histomorphologic diagnosis of aspergillosis and mucormycosis. Clin Infect Dis. 2015;61(11):1664\u201370.","journal-title":"Clin Infect Dis"},{"issue":"18","key":"909_CR18","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1056\/NEJMoa0810719","volume":"361","author":"EO Glocker","year":"2009","unstructured":"Glocker EO, Hennigs A, Nabavi M, Sch\u00e4ffer AA, Woellner C, Salzer U, et al. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med. 2009;361(18):1727\u201335.","journal-title":"N Engl J Med"},{"key":"909_CR19","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.3389\/fmicb.2018.02434","volume":"9","author":"A Vaezi","year":"2018","unstructured":"Vaezi A, Fakhim H, Abtahian Z, Khodavaisy S, Geramishoar M, Alizadeh A, et al. Frequency and geographic distribution of CARD9 mutations in patients with severe fungal infections. Front Microbiol. 2018;9:2434.","journal-title":"Front Microbiol"},{"issue":"13","key":"909_CR20","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1182\/blood-2012-08-450551","volume":"121","author":"A Drewniak","year":"2013","unstructured":"Drewniak A, Gazendam RP, Tool AT, van Houdt M, Jansen MH, van Hamme JL, et al. Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood. 2013;121(13):2385\u201392.","journal-title":"Blood."},{"issue":"1","key":"909_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1093\/cid\/ciu215","volume":"59","author":"C Gavino","year":"2014","unstructured":"Gavino C, Cotter A, Lichtenstein D, Lejtenyi D, Fortin C, Legault C, et al. CARD9 deficiency and spontaneous central nervous system candidiasis: complete clinical remission with GM-CSF therapy. Clin Infect Dis. 2014;59(1):81\u20134.","journal-title":"Clin Infect Dis"},{"issue":"12","key":"909_CR22","doi-asserted-by":"publisher","first-page":"e1005293","DOI":"10.1371\/journal.ppat.1005293","volume":"11","author":"RA Drummond","year":"2015","unstructured":"Drummond RA, Collar AL, Swamydas M, Rodriguez CA, Lim JK, Mendez LM, et al. CARD9-dependent neutrophil recruitment protects against fungal invasion of the central nervous system. PLoS Pathog. 2015;11(12):e1005293.","journal-title":"PLoS Pathog"},{"issue":"9","key":"909_CR23","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1097\/INF.0000000000000736","volume":"34","author":"M Herbst","year":"2015","unstructured":"Herbst M, Gazendam R, Reimnitz D, Sawalle-Belohradsky J, Groll A, Schlegel PG, et al. Chronic Candida albicans meningitis in a 4-year-old girl with a homozygous mutation in the CARD9 gene (Q295X). Pediatr Infect Dis J. 2015;34(9):999\u20131002.","journal-title":"Pediatr Infect Dis J"},{"issue":"6","key":"909_CR24","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.jaci.2014.12.1930","volume":"135","author":"F Lanternier","year":"2015","unstructured":"Lanternier F, Mahdaviani SA, Barbati E, Chaussade H, Koumar Y, Levy R, et al. Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species-induced meningoencephalitis, colitis, or both. J Allergy Clin Immunol. 2015;135(6):1558\u201368.e2.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"909_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s10875-016-0255-8","volume":"36","author":"AK Alves de Medeiros","year":"2016","unstructured":"Alves de Medeiros AK, Lodewick E, Bogaert DJ, Haerynck F, Van Daele S, Lambrecht B, et al. Chronic and invasive fungal infections in a family with CARD9 deficiency. J Clin Immunol. 2016;36(3):204\u20139.","journal-title":"J Clin Immunol"},{"issue":"4","key":"909_CR26","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/INF.0000000000001028","volume":"35","author":"F Celmeli","year":"2016","unstructured":"Celmeli F, Oztoprak N, Turkkahraman D, Seyman D, Mutlu E, Frede N, et al. Successful granulocyte colony-stimulating factor treatment of relapsing Candida albicans meningoencephalitis caused by CARD9 deficiency. Pediatr Infect Dis J. 2016;35(4):428\u201331.","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"909_CR27","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.jaci.2015.09.016","volume":"137","author":"C Gavino","year":"2016","unstructured":"Gavino C, Hamel N, Zeng JB, Legault C, Guiot MC, Chankowsky J, et al. Impaired RASGRF1\/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. J Allergy Clin Immunol. 2016;137(4):1178\u201388.e7.","journal-title":"J Allergy Clin Immunol"},{"key":"909_CR28","doi-asserted-by":"publisher","first-page":"bcr2015214117","DOI":"10.1136\/bcr-2015-214117","volume":"2016","author":"N Jones","year":"2016","unstructured":"Jones N, Garcez T, Newman W, Denning D. Endogenous Candida endophthalmitis and osteomyelitis associated with CARD9 deficiency. BMJ Case Rep. 2016;2016:bcr2015214117.","journal-title":"BMJ Case Rep"},{"issue":"18","key":"909_CR29","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1056\/NEJMoa1208487","volume":"369","author":"F Lanternier","year":"2013","unstructured":"Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C, et al. Deep dermatophytosis and inherited CARD9 deficiency. N Engl J Med. 2013;369(18):1704\u201314.","journal-title":"N Engl J Med"},{"issue":"5","key":"909_CR30","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s10875-015-0170-4","volume":"35","author":"AS Grumach","year":"2015","unstructured":"Grumach AS, de Queiroz-Telles F, Migaud M, Lanternier F, Filho NR, Palma SM, et al. A homozygous CARD9 mutation in a Brazilian patient with deep dermatophytosis. J Clin Immunol. 2015;35(5):486\u201390.","journal-title":"J Clin Immunol"},{"issue":"2","key":"909_CR31","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1001\/jamadermatol.2014.2154","volume":"151","author":"M Jachiet","year":"2015","unstructured":"Jachiet M, Lanternier F, Rybojad M, Bagot M, Ibrahim L, Casanova JL, et al. Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9. JAMA Dermatol. 2015;151(2):192\u20134.","journal-title":"JAMA Dermatol"},{"issue":"2","key":"909_CR32","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.mycmed.2017.01.001","volume":"27","author":"O Boudghene Stambouli","year":"2017","unstructured":"Boudghene Stambouli O, Amrani N, Boudghene Stambouli K, Bouali F. Dermatophytic disease with deficit in CARD9: a new case with a brain impairment. J Mycol Med. 2017;27(2):250\u20133.","journal-title":"J Mycol Med"},{"issue":"5","key":"909_CR33","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1111\/bjd.18146","volume":"181","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Mijiti J, Huang C, Song Y, Wan Z, Li R, et al. Deep dermatophytosis caused by Microsporum ferrugineum in a patient with CARD9 mutations. Br J Dermatol. 2019;181(5):1093\u20135.","journal-title":"Br J Dermatol"},{"issue":"2","key":"909_CR34","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/cup.13574","volume":"47","author":"RM Nazarian","year":"2020","unstructured":"Nazarian RM, Lilly E, Gavino C, Hamilos DL, Felsenstein D, Vinh DC, et al. Novel CARD9 mutation in a patient with chronic invasive dermatophyte infection (tinea profunda). J Cutan Pathol. 2020;47(2):166\u201370.","journal-title":"J Cutan Pathol"},{"issue":"12","key":"909_CR35","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/S1473-3099(19)30551-1","volume":"19","author":"C Huang","year":"2019","unstructured":"Huang C, Peng Y, Zhang Y, Li R, Wan Z, Wang X. Deep dermatophytosis caused by Trichophyton rubrum. Lancet Infect Dis. 2019;19(12):1380.","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"909_CR36","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.jaci.2013.09.033","volume":"133","author":"X Wang","year":"2014","unstructured":"Wang X, Wang W, Lin Z, Wang X, Li T, Yu J, et al. CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies. J Allergy Clin Immunol. 2014;133(3):905\u20138.e3.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"909_CR37","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1093\/infdis\/jiu412","volume":"211","author":"F Lanternier","year":"2015","unstructured":"Lanternier F, Barbati E, Meinzer U, Liu L, Pedergnana V, Migaud M, et al. Inherited CARD9 deficiency in 2 unrelated patients with invasive Exophiala infection. J Infect Dis. 2015;211(8):1241\u201350.","journal-title":"J Infect Dis"},{"issue":"3","key":"909_CR38","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jid.2017.10.009","volume":"138","author":"X Wang","year":"2018","unstructured":"Wang X, Zhang R, Wu W, Song Y, Wan Z, Han W, et al. Impaired specific antifungal immunity in CARD9-deficient patients with phaeohyphomycosis. J Invest Dermatol. 2018;138(3):607\u201317.","journal-title":"J Invest Dermatol"},{"issue":"7","key":"909_CR39","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1007\/s10875-018-0549-0","volume":"38","author":"CA Arango-Franco","year":"2018","unstructured":"Arango-Franco CA, Moncada-Velez M, Beltran CP, Berrio I, Mogollon C, Restrepo A, et al. Early-onset invasive infection due to Corynespora cassiicola associated with compound heterozygous CARD9 mutations in a Colombian patient. J Clin Immunol. 2018;38(7):794\u2013803.","journal-title":"J Clin Immunol"},{"issue":"7","key":"909_CR40","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s10875-019-00679-4","volume":"39","author":"Y Guo","year":"2019","unstructured":"Guo Y, Zhu Z, Gao J, Zhang C, Zhang X, Dang E, et al. The phytopathogenic fungus Pallidocercospora crystallina-caused localized subcutaneous phaeohyphomycosis in a patient with a homozygous missense CARD9 mutation. J Clin Immunol. 2019;39(7):713\u201325.","journal-title":"J Clin Immunol"},{"key":"909_CR41","doi-asserted-by":"publisher","first-page":"938","DOI":"10.3389\/fneur.2019.00938","volume":"10","author":"C Wang","year":"2019","unstructured":"Wang C, Xing H, Jiang X, Zeng J, Liu Z, Chen J, et al. Cerebral phaeohyphomycosis caused by Exophiala dermatitidis in a Chinese CARD9-deficient patient: a case report and literature review. Front Neurol. 2019;10:938.","journal-title":"Front Neurol"},{"issue":"2","key":"909_CR42","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s10875-019-00740-2","volume":"40","author":"L Perez","year":"2020","unstructured":"Perez L, Messina F, Negroni R, Arechavala A, Bustamante J, Oleastro M, et al. Inherited CARD9 deficiency in a patient with both Exophiala spinifera and Aspergillus nomius severe infections. J Clin Immunol. 2020;40(2):359\u201366.","journal-title":"J Clin Immunol"},{"issue":"17","key":"909_CR43","doi-asserted-by":"publisher","first-page":"e89890","DOI":"10.1172\/jci.insight.89890","volume":"1","author":"N Rieber","year":"2016","unstructured":"Rieber N, Gazendam RP, Freeman AF, Hsu AP, Collar AL, Sugui JA, et al. Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. JCI Insight. 2016;1(17):e89890.","journal-title":"JCI Insight"},{"issue":"1","key":"909_CR44","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/bjd.17144","volume":"180","author":"X Wang","year":"2019","unstructured":"Wang X, Wang A, Wang X, Li R, Yu J. Cutaneous mucormycosis caused by Mucor irregularis in a patient with CARD9 deficiency. Br J Dermatol. 2019;180(1):213\u20134.","journal-title":"Br J Dermatol"},{"issue":"5","key":"909_CR45","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1111\/bjd.17092","volume":"180","author":"C Quan","year":"2018","unstructured":"Quan C, Li X, Shi RF, Zhao XQ, Xu H, Wang B, et al. Recurrent fungal infections in a Chinese patient with CARD9 deficiency and a review of 48 cases. Br J Dermatol. 2018;180(5):1221\u20135.","journal-title":"Br J Dermatol"},{"issue":"3","key":"909_CR46","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1007\/s10875-020-00759-w","volume":"40","author":"B Erman","year":"2020","unstructured":"Erman B, Firtina S, Aksoy BA, Aydogdu S, Genc GE, Dogan O, et al. Invasive Saprochaete capitata infection in a patient with autosomal recessive CARD9 deficiency and a review of the literature. J Clin Immunol. 2020;40(3):466\u201374.","journal-title":"J Clin Immunol"},{"issue":"11","key":"909_CR47","doi-asserted-by":"publisher","first-page":"e93156","DOI":"10.1172\/jci.insight.93156","volume":"2","author":"MS Lionakis","year":"2017","unstructured":"Lionakis MS, Iliev ID, Hohl TM. Immunity against fungi. JCI Insight. 2017;2(11):e93156.","journal-title":"JCI Insight"},{"issue":"1","key":"909_CR48","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1128\/IAI.05939-11","volume":"80","author":"MA Gessner","year":"2012","unstructured":"Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, et al. Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect Immun. 2012;80(1):410\u20137.","journal-title":"Infect Immun"},{"issue":"6","key":"909_CR49","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1093\/infdis\/jir882","volume":"205","author":"I Rubino","year":"2012","unstructured":"Rubino I, Coste A, Le Roy D, Roger T, Jaton K, Boeckh M, et al. Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6. J Infect Dis. 2012;205(6):944\u201354.","journal-title":"J Infect Dis"},{"issue":"2","key":"909_CR50","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jdermsci.2018.08.005","volume":"92","author":"W Wu","year":"2018","unstructured":"Wu W, Zhang R, Wang X, Song Y, Li R. Subcutaneous infection with dematiaceous fungi in Card9 knockout mice reveals association of impair neutrophils and Th cell response. J Dermatol Sci. 2018;92(2):215\u20138.","journal-title":"J Dermatol Sci"},{"issue":"5","key":"909_CR51","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1128\/EC.00031-12","volume":"11","author":"N Grahl","year":"2012","unstructured":"Grahl N, Shepardson KM, Chung D, Cramer RA. Hypoxia and fungal pathogenesis: to air or not to air? Eukaryot Cell. 2012;11(5):560\u201370.","journal-title":"Eukaryot Cell"},{"issue":"5","key":"909_CR52","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41590-019-0377-2","volume":"20","author":"RA Drummond","year":"2019","unstructured":"Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, et al. CARD9+ microglia promote antifungal immunity via IL-1\u03b2- and CXCL1-mediated neutrophil recruitment. Nat Immunol. 2019;20(5):559\u201370.","journal-title":"Nat Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-020-00909-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-020-00909-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-020-00909-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T21:11:28Z","timestamp":1612386688000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-020-00909-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["909"],"URL":"https:\/\/doi.org\/10.1007\/s10875-020-00909-0","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,12]]},"assertion":[{"value":"5 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Clinical Research Ethics Committee of the Peking University First Hospital. We obtained blood samples from the patient, his son, and three ethnically matched healthy volunteers, after obtaining informed consent. The patient gave permission to publish his images and medical information. Animal studies were approved by the Institutional Ethics Committee of Peking University First Hospital in accordance with the institutional guidelines.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}