{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:27:02Z","timestamp":1790368022881,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10875-020-00947-8","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T04:04:14Z","timestamp":1609905854000},"page":"694-697","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Soluble Interleukin-2 Receptor Is a Promising Serum Biomarker for Granulomatous Disease in Common Variable Immune Deficiency"],"prefix":"10.1007","volume":"41","author":[{"given":"Astrid C.","family":"van Stigt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgil A. S. H.","family":"Dalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M. A.","family":"Nagtzaam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian A.","family":"van Rijswijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara H.","family":"Barendregt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Martin","family":"van Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"IJspeert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-3156","authenticated-orcid":false,"given":"Willem A.","family":"Dik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"947_CR1","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.jaip.2019.02.004","volume":"7","author":"MG Seidel","year":"2019","unstructured":"Seidel MG, Kindle G, Gathmann B, Quinti I, Buckland M, van Montfrans J, et al. The European Society for Immunodeficiencies (ESID) registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract. 2019;7:1763\u201370.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"7","key":"947_CR2","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","volume":"119","author":"ES Resnick","year":"2012","unstructured":"Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood. 2012;119(7):1650\u20137.","journal-title":"Blood"},{"issue":"6","key":"947_CR3","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/j.1365-2141.2009.07669.x","volume":"145","author":"H Chapel","year":"2009","unstructured":"Chapel H, Cunningham-Rundles C. Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions. Br J Haematol. 2009;145(6):709\u201327.","journal-title":"Br J Haematol"},{"key":"947_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fimmu.2020.00149","volume":"11","author":"HE Ho","year":"2020","unstructured":"Ho HE, Cunningham-Rundles C. Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis. Front Immunol. 2020;11:149.","journal-title":"Front Immunol"},{"issue":"2","key":"947_CR5","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jaci.2004.05.057","volume":"114","author":"CA Bates","year":"2004","unstructured":"Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM. Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol. 2004;114(2):415\u201321.","journal-title":"J Allergy Clin Immunol"},{"issue":"1\u20132","key":"947_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.imlet.2003.11.023","volume":"92","author":"DO Co","year":"2004","unstructured":"Co DO, Hogan LH, Il-Kim S, Sandor M. T cell contributions to the different phases of granuloma formation. Immunol Lett. 2004;92(1\u20132):135\u201342.","journal-title":"Immunol Lett"},{"key":"947_CR7","doi-asserted-by":"publisher","first-page":"4951587","DOI":"10.1155\/2016\/4951587","volume":"2016","author":"A Coraglia","year":"2016","unstructured":"Coraglia A, et al. Common variable immunodeficiency and circulating TFH. J Immunol Res. 2016;2016:4951587.","journal-title":"J Immunol Res"},{"key":"947_CR8","doi-asserted-by":"publisher","unstructured":"Maglione PJ, Gyimesi G, Cols M, Radigan L, Ko HM, Weinberger T, Lee BH, Grasset EK, Rahman AH, Cerutti A, Cunningham-Rundles C. BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency. JCI Insight. 2019;4(5):e122728. https:\/\/doi.org\/10.1172\/jci.insight.122728.","DOI":"10.1172\/jci.insight.122728"},{"issue":"3","key":"947_CR9","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000504598","volume":"181","author":"I Ogulur","year":"2020","unstructured":"Ogulur I, Kiykim A, Baser D, Karakoc-Aydiner E, Ozen A, Baris S. Lymphocyte subset abnormalities in pediatric-onset common variable immunodeficiency. Int Arch Allergy Immunol. 2020;181(3):228\u201337.","journal-title":"Int Arch Allergy Immunol"},{"issue":"5","key":"947_CR10","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.anai.2017.01.004","volume":"118","author":"S Hartono","year":"2017","unstructured":"Hartono S, Motosue MS, Khan S, Rodriguez V, Iyer VN, Divekar R, et al. Predictors of granulomatous lymphocytic interstitial lung disease in common variable immunodeficiency. Ann Allergy Asthma Immunol. 2017;118(5):614\u201320.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"947_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1155\/S0962935193000018","volume":"2","author":"C Caruso","year":"1993","unstructured":"Caruso C, Candore G, Cigna D, Colucci AT, Modica MA. Biological significance of soluble IL-2 receptor. Mediat Inflamm. 1993;2(1):3\u201321.","journal-title":"Mediat Inflamm"},{"issue":"3","key":"947_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1155\/MI.2005.121","volume":"2005","author":"AM Witkowska","year":"2005","unstructured":"Witkowska AM. On the role of sIL-2R measurements in rheumatoid arthritis and cancers. Mediat Inflamm. 2005;2005(3):121\u201330.","journal-title":"Mediat Inflamm"},{"issue":"2","key":"947_CR13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.clim.2004.08.012","volume":"113","author":"DO Co","year":"2004","unstructured":"Co DO, Hogan LH, Kim SI, Sandor M. Mycobacterial granulomas: keys to a long-lasting host-pathogen relationship. Clin Immunol. 2004;113(2):130\u20136.","journal-title":"Clin Immunol"},{"issue":"5","key":"947_CR14","first-page":"220","volume":"78","author":"WA Dik","year":"2020","unstructured":"Dik WA, Heron M. Clinical significance of soluble interleukin-2 receptor measurement in immune-mediated diseases. Neth J Med. 2020;78(5):220\u201331.","journal-title":"Neth J Med"},{"issue":"8","key":"947_CR15","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s10875-014-0099-z","volume":"34","author":"Z Hel","year":"2014","unstructured":"Hel Z, Huijbregts RPH, Xu J, Nechvatalova J, Vlkova M, Litzman J. Altered serum cytokine signature in common variable immunodeficiency. J Clin Immunol. 2014;34(8):971\u20138.","journal-title":"J Clin Immunol"},{"issue":"3","key":"947_CR16","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1365-2249.2012.04655.x","volume":"170","author":"J Litzman","year":"2012","unstructured":"Litzman J, Nechvatalova J, Xu J, Ticha O, Vlkova M, Hel Z. Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia. Clin Exp Immunol. 2012;170(3):321\u201332.","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"947_CR17","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1365-2249.1991.tb05805.x","volume":"86","author":"ME North","year":"1991","unstructured":"North ME, Spickett GP, Webster AD, Farrant J. Raised serum levels of CD8, CD25 and beta 2-microglobulin in common variable immunodeficiency. Clin Exp Immunol. 1991;86(2):252\u20135.","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"947_CR18","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1038\/mi.2016.18","volume":"9","author":"SF Jorgensen","year":"2016","unstructured":"Jorgensen SF, et al. Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunol. 2016;9(6):1455\u201365.","journal-title":"Mucosal Immunol"},{"issue":"10","key":"947_CR19","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1038\/ajg.2016.329","volume":"111","author":"SF Jorgensen","year":"2016","unstructured":"Jorgensen SF, et al. A cross-sectional study of the prevalence of gastrointestinal symptoms and pathology in patients with common variable immunodeficiency. Am J Gastroenterol. 2016;111(10):1467\u201375.","journal-title":"Am J Gastroenterol"},{"issue":"6246","key":"947_CR20","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1126\/science.aaa1663","volume":"349","author":"B Lo","year":"2015","unstructured":"Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, et al. Autoimmune disease. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science. 2015;349(6246):436\u201340.","journal-title":"Science"},{"issue":"3","key":"947_CR21","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.jaci.2017.05.022","volume":"141","author":"FJ Alroqi","year":"2018","unstructured":"Alroqi FJ, Charbonnier LM, Baris S, Kiykim A, Chou J, Platt CD, et al. Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. J Allergy Clin Immunol. 2018;141(3):1050\u20139 e10.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"947_CR22","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jaip.2014.09.019","volume":"3","author":"J Vitale","year":"2015","unstructured":"Vitale J, Convers KD, Goretzke S, Guzman M, Noyes B, Parkar N, et al. Serum IL-12 and soluble IL-2 receptor levels as possible biomarkers of granulomatous and lymphocytic interstitial lung disease in common variable immunodeficiency: a case report. J Allergy Clin Immunol Pract. 2015;3(2):273\u20136.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"10","key":"947_CR23","doi-asserted-by":"publisher","first-page":"e0223897","DOI":"10.1371\/journal.pone.0223897","volume":"14","author":"LEM Eurelings","year":"2019","unstructured":"Eurelings LEM, Miedema JR, Dalm VASH, van Daele PLA, van Hagen PM, van Laar JAM, et al. Sensitivity and specificity of serum soluble interleukin-2 receptor for diagnosing sarcoidosis in a population of patients suspected of sarcoidosis. PLoS One. 2019;14(10):e0223897.","journal-title":"PLoS One"},{"issue":"2","key":"947_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.rmed.2014.11.009","volume":"109","author":"AD Vorselaars","year":"2015","unstructured":"Vorselaars AD, et al. ACE and sIL-2R correlate with lung function improvement in sarcoidosis during methotrexate therapy. Respir Med. 2015;109(2):279\u201385.","journal-title":"Respir Med"},{"issue":"3","key":"947_CR25","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1055\/s-0034-1376862","volume":"35","author":"JW Verbsky","year":"2014","unstructured":"Verbsky JW, Routes JM. Sarcoidosis and common variable immunodeficiency: similarities and differences. Semin Respir Crit Care Med. 2014;35(3):330\u20135.","journal-title":"Semin Respir Crit Care Med"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-020-00947-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-020-00947-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-020-00947-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T22:32:26Z","timestamp":1614637946000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-020-00947-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["947"],"URL":"https:\/\/doi.org\/10.1007\/s10875-020-00947-8","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,6]]},"assertion":[{"value":"11 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}