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In a cohort of patients with CVID, we sought to identify predictors of bronchiectasis. Secondly, we sought to describe the impact of bronchiectasis on lung function, infection risk, and quality of life. We conducted an observational cohort study of 110 patients with CVID and an available pulmonary computed tomography scan. The prevalence of bronchiectasis was 53%, with most of these patients (54%) having mild disease. Patients with bronchiectasis had lower median serum immunoglobulin (Ig) concentrations, especially long-term IgM (0 vs 0.25\u00a0g\/l;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and pre-treatment IgG (1.3 vs 3.7\u00a0g\/l;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). CVID patients with bronchiectasis had worse forced expiratory volume in one second (2.10 vs 2.99\u00a0l;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and an annual decline in forced expiratory volume in one second of 25\u00a0ml\/year (vs 8\u00a0ml\/year in patients without bronchiectasis;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). Patients with bronchiectasis also reported more annual respiratory tract infections (1.77 vs 1.25 infections\/year,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04) and a poorer quality of life (26 vs 14 points in the St George\u2019s Respiratory Questionnaire;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Low serum immunoglobulin M concentration identifies patients at risk for bronchiectasis in CVID and may play a role in pathogenesis. Bronchiectasis is relevant because it is associated with frequent respiratory tract infections, poorer lung function, a greater rate of lung function decline, and a lower quality of life.\n                  <\/jats:p>","DOI":"10.1007\/s10875-022-01206-8","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T02:02:41Z","timestamp":1641866561000},"page":"572-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Predictive Factors for and Complications of Bronchiectasis in Common Variable Immunodeficiency Disorders"],"prefix":"10.1007","volume":"42","author":[{"given":"Johannes M.","family":"Sperlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Grimbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Soetedjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Workman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan O.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Hurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"1206_CR1","doi-asserted-by":"publisher","unstructured":"Alejandria MM, Lansang MAD, Dans LF, et al. 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Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center. Respir Res. 2019;20:275. https:\/\/doi.org\/10.1186\/s12931-019-1242-4.","journal-title":"Respir Res"},{"key":"1206_CR9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fimmu.2020.00149","volume":"11","author":"H-E Ho","year":"2020","unstructured":"Ho H-E, Cunningham-Rundles C. Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis. Front Immunol. 2020;11:149. https:\/\/doi.org\/10.3389\/fimmu.2020.00149.","journal-title":"Front Immunol"},{"key":"1206_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10875-017-0381-y","volume":"37","author":"JP Hodkinson","year":"2017","unstructured":"Hodkinson JP, Bangs C, Wartenberg-Demand A, et al. 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Veronika Soetedjo: no conflicts of interest; Sarita Workman: no conflicts of interest; Siobhan O Burns: no conflicts of interest; David M Lowe: Dr. Lowe has received travel and subsistence costs for unpaid consultancy work from CSL Behring, has participated in an advisory board for Merck, and has received research grants from UCL\/UCLH Biomedial Research Centre, Bristol Myers Squibb, LifeArc, MRC (UK) and the British Society for Antimicrobial Chemotherapy, all outside the submitted work; John R Hurst: no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Patients were recruited from the joint Immunology-Respiratory service at the Royal Free Hospital, London, UK. All participants provided written, informed consent in accordance with the Declaration of Helsinki and ethical approval NRES committee London (REC 04\/Q0501\/119).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}