{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:26:35Z","timestamp":1785687995251,"version":"3.56.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10875-022-01211-x","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T06:02:43Z","timestamp":1643263363000},"page":"653-664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comprehensive Assessment of Skin Disorders in Patients with Common Variable Immunodeficiency\u00a0(CVID)"],"prefix":"10.1007","volume":"42","author":[{"given":"Ali","family":"Zarezadeh Mehrabadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Aghamohamadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Abolhassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Aghamohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-6595","authenticated-orcid":false,"given":"Reza","family":"Yazdani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"issue":"1","key":"1211_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.18176\/jiaci.0388","volume":"30","author":"R Yazdani","year":"2020","unstructured":"Yazdani R, Habibi S, Sharifi L, Azizi G, Abolhassani H, Olbrich P, et al. Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management. J Investig Allergol Clin Immunol. 2020;30(1):14\u201334.","journal-title":"J Investig Allergol Clin Immunol."},{"issue":"10","key":"1211_CR2","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.2217\/imt.14.67","volume":"6","author":"S Albin","year":"2014","unstructured":"Albin S, Cunningham-Rundles C. An update on the use of immunoglobulin for the treatment of immunodeficiency disorders. Immunotherapy. 2014;6(10):1113\u201326.","journal-title":"Immunotherapy."},{"issue":"1","key":"1211_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10875-020-00763-0","volume":"40","author":"SG Tangye","year":"2020","unstructured":"Tangye SG, Al-Herz W, Bousfiha A, Chatila T, Cunningham-Rundles C, Etzioni A, et al. Correction to: human inborn errors of immunity: 2019 update on the classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2020;40(1):65.","journal-title":"J Clin Immunol."},{"issue":"1","key":"1211_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3109\/08830185.2015.1136306","volume":"35","author":"R Yazdani","year":"2016","unstructured":"Yazdani R, Abolhassani H, Rezaei N, Azizi G, Hammarstr\u00f6m L, Aghamohammadi A. Evaluation of known defective signaling-associated molecules in patients who primarily diagnosed as common variable immunodeficiency. Int Rev Immunol. 2016;35(1):7\u201324.","journal-title":"Int Rev Immunol."},{"issue":"3","key":"1211_CR5","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1007\/s10875-021-00980-1","volume":"41","author":"SG Tangye","year":"2021","unstructured":"Tangye SG, Al-Herz W, Bousfiha A, Cunningham-Rundles C, Franco JL, Holland SM, et al. The ever-increasing array of novel inborn errors of immunity: an interim update by the IUIS committee. J Clin Immunol. 2021;41(3):666\u201379.","journal-title":"J Clin Immunol."},{"issue":"3","key":"1211_CR6","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.jaip.2018.09.004","volume":"7","author":"R Yazdani","year":"2019","unstructured":"Yazdani R, Abolhassani H, Kiaee F, Habibi S, Azizi G, Tavakol M, et al. Comparison of common monogenic defects in a large predominantly antibody deficiency cohort. J Allergy Clin Immunol Pract. 2019;7(3):864-78 e9.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"1","key":"1211_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s41436-018-0012-x","volume":"21","author":"H Abolhassani","year":"2019","unstructured":"Abolhassani H, Aghamohammadi A, Fang M, Rezaei N, Jiang C, Liu X, et al. Clinical implications of systematic phenotyping and exome sequencing in patients with primary antibody deficiency. Genet Med. 2019;21(1):243\u201351.","journal-title":"Genet Med."},{"issue":"9","key":"1211_CR8","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1182\/blood.2019000929","volume":"135","author":"H Abolhassani","year":"2020","unstructured":"Abolhassani H, Hammarstrom L, Cunningham-Rundles C. Current genetic landscape in common variable immune deficiency. Blood. 2020;135(9):656\u201367.","journal-title":"Blood."},{"issue":"2","key":"1211_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2174\/1871530316666160724214418","volume":"16","author":"G Azizi","year":"2016","unstructured":"Azizi G, Abolhassani H, Asgardoon MH, Rahnavard J, Dizaji MZ, Yazdani R, et al. The use of Immunoglobulin therapy in primary immunodeficiency diseases. Endocr Metab Immune Disord Drug Targets. 2016;16(2):80\u20138.","journal-title":"Endocr Metab Immune Disord Drug Targets."},{"key":"1211_CR10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fimmu.2020.00149","volume":"11","author":"HE Ho","year":"2020","unstructured":"Ho HE, Cunningham-Rundles C. Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis. Front Immunol. 2020;11:149.","journal-title":"Front Immunol."},{"issue":"2","key":"1211_CR11","first-page":"107","volume":"18","author":"A Aghamohammadi","year":"2010","unstructured":"Aghamohammadi A, Abolhassani H, Rezaei N, Kalantari N, Tamizifar B, Cheraghi T, et al. Cutaneous granulomas in common variable immunodeficiency: case report and review of literature. Acta Dermatovenerol Croat. 2010;18(2):107\u201313.","journal-title":"Acta Dermatovenerol Croat."},{"issue":"1","key":"1211_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00296-009-0897-4","volume":"30","author":"H Artac","year":"2009","unstructured":"Artac H, Bozkurt B, Talim B, Reisli I. Sarcoid-like granulomas in common variable immunodeficiency. Rheumatol Int. 2009;30(1):109\u201312.","journal-title":"Rheumatol Int."},{"issue":"3","key":"1211_CR13","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/all.13681","volume":"74","author":"J de Wit","year":"2019","unstructured":"de Wit J, Brada RJK, van Veldhuizen J, Dalm V, Pasmans S. Skin disorders are prominent features in primary immunodeficiency diseases: a systematic overview of current data. Allergy. 2019;74(3):464\u201382.","journal-title":"Allergy."},{"issue":"7","key":"1211_CR14","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1007\/s10875-018-0556-1","volume":"38","author":"H Abolhassani","year":"2018","unstructured":"Abolhassani H, Kiaee F, Tavakol M, Chavoshzadeh Z, Mahdaviani SA, Momen T, et al. Fourth update on the Iranian National Registry of Primary Immunodeficiencies: integration of molecular diagnosis. J Clin Immunol. 2018;38(7):816\u201332.","journal-title":"J Clin Immunol."},{"issue":"6","key":"1211_CR15","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.jaip.2019.02.004","volume":"7","author":"MG Seidel","year":"2019","unstructured":"Seidel MG, Kindle G, Gathmann B, Quinti I, Buckland M, van Montfrans J, et al. The European Society for Immunodeficiencies (ESID) registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract. 2019;7(6):1763\u201370.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"1","key":"1211_CR16","first-page":"1","volume":"2","author":"H Abolhassani","year":"2019","unstructured":"Abolhassani H, Tavakol M, Chavoshzadeh Z, Mahdaviani SA, Momen T, Yazdani R, et al. National consensus on diagnosis and management guidelines for primary immunodeficiency. Immunol Genet J. 2019;2(1):1\u201321.","journal-title":"Immunol Genet J."},{"issue":"6","key":"1211_CR17","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.anai.2020.03.019","volume":"124","author":"S Fekrvand","year":"2020","unstructured":"Fekrvand S, Abolhassani H, Delavari S, Yazdani R, Aghamohammadi A. Are asthma and allergic diseases phenotypic markers for patients with common variable immunodeficiency? Ann Allergy Asthma Immunol. 2020;124(6):636.","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"2","key":"1211_CR18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/gim.2016.190","volume":"19","author":"SS Kalia","year":"2017","unstructured":"Kalia SS, Adelman K, Bale SJ, Chung WK, Eng C, Evans JP, et al. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genet Med. 2017;19(2):249\u201355.","journal-title":"Genet Med."},{"issue":"6","key":"1211_CR19","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.jaci.2011.02.039","volume":"127","author":"JS Orange","year":"2011","unstructured":"Orange JS, Glessner JT, Resnick E, Sullivan KE, Lucas M, Ferry B, et al. Genome-wide association identifies diverse causes of common variable immunodeficiency. J Allergy Clin Immunol. 2011;127(6):1360-7.e6.","journal-title":"J Allergy Clin Immunol."},{"issue":"2","key":"1211_CR20","first-page":"277","volume":"112","author":"H Chapel","year":"2008","unstructured":"Chapel H, Lucas M, Lee M, Bjorkander J, Webster D, Grimbacher B, et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood J Am Soc Hematol. 2008;112(2):277\u201386.","journal-title":"Blood J Am Soc Hematol."},{"issue":"7","key":"1211_CR21","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s10875-019-00674-9","volume":"39","author":"C Baloh","year":"2019","unstructured":"Baloh C, Reddy A, Henson M, Prince K, Buckley R, Lugar P. 30-year review of pediatric- and adult-onset CVID: clinical correlates and prognostic indicators. J Clin Immunol. 2019;39(7):678\u201387.","journal-title":"J Clin Immunol."},{"issue":"4","key":"1211_CR22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.2500\/ajra.2013.27.3899","volume":"27","author":"JS Tam","year":"2013","unstructured":"Tam JS, Routes JM. Common variable immunodeficiency. Am J Rhinol Allergy. 2013;27(4):260\u20135.","journal-title":"Am J Rhinol Allergy."},{"issue":"9","key":"1211_CR23","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1086\/606059","volume":"49","author":"M Malphettes","year":"2009","unstructured":"Malphettes M, G\u00e9rard L, Carmagnat M, Mouillot G, Vince N, Boutboul D, et al. Late-onset combined immune deficiency: a subset of common variable immunodeficiency with severe T cell defect. Clin Infect Dis. 2009;49(9):1329\u201338.","journal-title":"Clin Infect Dis."},{"issue":"6","key":"1211_CR24","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1007\/s10875-017-0415-5","volume":"37","author":"LA Sanchez","year":"2017","unstructured":"Sanchez LA, Maggadottir SM, Pantell MS, Lugar P, Rundles CC, Sullivan KE, et al. Two sides of the same coin: pediatric-onset and adult-onset common variable immune deficiency. J Clin Immunol. 2017;37(6):592\u2013602.","journal-title":"J Clin Immunol."},{"issue":"4","key":"1211_CR25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.1600-0714.1993.tb01049.x","volume":"22","author":"SR Porter","year":"1993","unstructured":"Porter SR, Scully C. Orofacial manifestations in primary immunodeficiencies: common variable immunodeficiencies. J Oral Pathol Med. 1993;22(4):157\u20138.","journal-title":"J Oral Pathol Med."},{"key":"1211_CR26","unstructured":"Moin A, FARHOUDI A, MOEIN M, Pourpak Z, Bazargan N. Cutaneous manifestations of primary immunodeficiency diseases in children. 2006."},{"issue":"1","key":"1211_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3906\/sag-1503-22","volume":"47","author":"UH Mu\u015fabak","year":"2017","unstructured":"Mu\u015fabak UH, Demirel F, Ye\u015fillik S, Baysan A, Selcuk A, Kartal \u00d6, et al. Adults with common variable immunodeficiency: a singlecenter experience. Turk J Med Sci. 2017;47(1):1\u201312.","journal-title":"Turk J Med Sci."},{"issue":"5","key":"1211_CR28","first-page":"369","volume":"25","author":"G Gualdi","year":"2015","unstructured":"Gualdi G, Lougaris V, Baronio M, Vitali M, Tampella G, Moratto D, et al. Burden of skin disease in selective IgA deficiency and common variable immunodeficiency. J Investig Allergol Clin Immunol. 2015;25(5):369\u201371.","journal-title":"J Investig Allergol Clin Immunol."},{"issue":"1","key":"1211_CR29","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1001\/archderm.143.1.115","volume":"143","author":"P Toossi","year":"2007","unstructured":"Toossi P, Nabai L, Alaee Z, Ahmadi H, Saatee S. Prevalence of skin diseases and cutaneous manifestations among Iranian children: a survey of 1417 children. Arch Dermatol. 2007;143(1):115\u201326.","journal-title":"Arch Dermatol."},{"issue":"8","key":"1211_CR30","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/j.1365-4632.2004.02140.x","volume":"44","author":"S Baghestani","year":"2005","unstructured":"Baghestani S, Zare S, Mahboobi A-A. Skin disease patterns in Hormozgan, Iran. Int J Dermatol. 2005;44(8):641\u20135.","journal-title":"Int J Dermatol."},{"issue":"9","key":"1211_CR31","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.autrev.2016.07.011","volume":"15","author":"G Patuzzo","year":"2016","unstructured":"Patuzzo G, Barbieri A, Tinazzi E, Veneri D, Argentino G, Moretta F, et al. Autoimmunity and infection in common variable immunodeficiency (CVID). Autoimmun Rev. 2016;15(9):877\u201382.","journal-title":"Autoimmun Rev."},{"issue":"10","key":"1211_CR32","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1086\/587669","volume":"46","author":"E Oksenhendler","year":"2008","unstructured":"Oksenhendler E, G\u00e9rard L, Fieschi C, Malphettes M, Mouillot G, Jaussaud R, et al. Infections in 252 patients with common variable immunodeficiency. Clin Infect Dis. 2008;46(10):1547\u201354.","journal-title":"Clin Infect Dis."},{"issue":"4","key":"1211_CR33","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1556\/EUJMI-D-14-00026","volume":"4","author":"S Duraisingham","year":"2014","unstructured":"Duraisingham S, Hanson S, Buckland M, Grigoriadou S, Longhurst H. Pseudomonas infection in antibody deficient patients. Eur J Microbiol Immunol. 2014;4(4):198\u2013203.","journal-title":"Eur J Microbiol Immunol."},{"issue":"4","key":"1211_CR34","doi-asserted-by":"publisher","first-page":"233","DOI":"10.18176\/jiaci.0069","volume":"26","author":"G Azizi","year":"2016","unstructured":"Azizi G, Rezaei N, Kiaee F, Tavakolinia N, Yazdani R, Mirshafiey A, et al. T-cell abnormalities in common variable immunodeficiency. J Investig Allergol Clin Immunol. 2016;26(4):233\u201343.","journal-title":"J Investig Allergol Clin Immunol."},{"key":"1211_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cellimm.2016.12.007","volume":"315","author":"G Azizi","year":"2017","unstructured":"Azizi G, Hafezi N, Mohammadi H, Yazdani R, Alinia T, Tavakol M, et al. Abnormality of regulatory T cells in common variable immunodeficiency. Cell Immunol. 2017;315:11\u20137.","journal-title":"Cell Immunol."},{"issue":"6","key":"1211_CR36","first-page":"1361","volume":"37","author":"I Rousalova","year":"2010","unstructured":"Rousalova I, Krepela E. Granzyme B-induced apoptosis in cancer cells and its regulation (review). Int J Oncol. 2010;37(6):1361\u201378.","journal-title":"Int J Oncol."},{"key":"1211_CR37","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.matbio.2017.12.005","volume":"75\u201376","author":"CT Turner","year":"2019","unstructured":"Turner CT, Lim D, Granville DJ. Granzyme B in skin inflammation and disease. Matrix Biol. 2019;75\u201376:126\u201340.","journal-title":"Matrix Biol."},{"issue":"2","key":"1211_CR38","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/jid.2012.344","volume":"133","author":"FJ Duncan","year":"2013","unstructured":"Duncan FJ, Silva KA, Johnson CJ, King BL, Szatkiewicz JP, Kamdar SP, et al. Endogenous retinoids in the pathogenesis of alopecia areata. J Investig Dermatol. 2013;133(2):334\u201343.","journal-title":"J Investig Dermatol."},{"key":"1211_CR39","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3389\/fimmu.2020.00338","volume":"11","author":"A Pecoraro","year":"2020","unstructured":"Pecoraro A, Crescenzi L, Varricchi G, Marone G, Spadaro G. Heterogeneity of liver disease in common variable immunodeficiency disorders. Front Immunol. 2020;11:338.","journal-title":"Front Immunol."},{"key":"1211_CR40","doi-asserted-by":"crossref","unstructured":"Moschos AKSBJ. Skin manifestations of liver diseases. Ann Hepatol. 2007:181\u20134.","DOI":"10.1016\/S1665-2681(19)31926-X"},{"issue":"5","key":"1211_CR41","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.jaci.2019.12.896","volume":"145","author":"VK Tesch","year":"2020","unstructured":"Tesch VK, Abolhassani H, Shadur B, Zobel J, Mareika Y, Sharapova S, et al. Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score. J Allergy Clin Immunol. 2020;145(5):1452\u201363.","journal-title":"J Allergy Clin Immunol."},{"issue":"6","key":"1211_CR42","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/s10875-020-00799-2","volume":"40","author":"S Meshaal","year":"2020","unstructured":"Meshaal S, El Hawary R, Adel R, Abd Elaziz D, Erfan A, Lotfy S, et al. Clinical phenotypes and immunological characteristics of 18 Egyptian LRBA deficiency patients. J Clin Immunol. 2020;40(6):820\u201332.","journal-title":"J Clin Immunol."}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01211-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-022-01211-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01211-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T01:08:35Z","timestamp":1659056915000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-022-01211-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,27]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1211"],"URL":"https:\/\/doi.org\/10.1007\/s10875-022-01211-x","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,27]]},"assertion":[{"value":"2 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Tehran University of Medical (IR.TUMS.VCR.REC.1396.2018). Informed consent was obtained from all individual participants or parents included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Standards and Consent to Participate"}},{"value":"Informed consent was obtained from all individual patients or parents to publish the identifiable details which can include case history and\/or details within the text to be published in the Journal of Clinical Immunology.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}