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IEI prevalence data from Northern Ireland was last published in 2018. Using data from the United Kingdom Primary Immune Deficiency (UKPID) and European Society for Immunodeficiencies (ESID) registries, we reviewed all registered cases of IEI affecting adult patients\u2009\u2265\u200918\u00a0years of age from the two largest immunology specialist centres in Northern Ireland and the Republic of Ireland, respectively and calculated the combined minimum adult prevalence of IEI on the island of Ireland for the first time. We also recorded data pertaining to presenting symptoms of IEI, diagnostic delay, immunoglobulin data, and genetic testing, as well as briefly reporting data pertaining to secondary immunodeficiency in both countries. As of 1 May 2020, we identified a minimum adult IEI prevalence in Ireland of 8.85\/100,000 population.<\/jats:p>","DOI":"10.1007\/s10875-022-01274-w","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T11:04:16Z","timestamp":1653303856000},"page":"1293-1299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inborn Errors of Immunity on the Island of Ireland \u2014 a Cross-Jurisdictional UKPID\/ESID Registry Report"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-0417","authenticated-orcid":false,"given":"Paul","family":"Ryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyanka","family":"Redenbaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne","family":"McGucken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kindle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Devlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Coulter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Buckland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko R. 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Local ethics approval to contribute to the ESID database was obtained in St. James\u2019s Hospital, Dublin, in 2019 (REC: 2019\u201310 List 39(2)).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All the patients included in the ESID registry provided their consent in writing in compliance with General Data Protection Regulation (GDPR).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All the patients included in the ESID registry provided their consent in writing in compliance with General Data Protection Regulation (GDPR).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"J. David M. Edgar has received speaker fees\/lecture fees from Takeda Pharmaceutical Company and ALK Abello and has received advisor fees on the advisory board of Pharming Group. Lisa A. Devlin has received sponsorship to attend ESID from CSL Behring and speaker fees from A\/K to speak at a GP conference. Niall Conlon has received an unrestricted grant from Takeda Pharmaceutical Company supporting research in an unrelated project (COVID-19).All the other authors declare no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}