{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:38:44Z","timestamp":1780475924225,"version":"3.54.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100006021","name":"USIDnet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006021","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s10875-022-01317-2","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T14:02:41Z","timestamp":1656770561000},"page":"1545-1552","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Risk Factors of Pneumonia in Primary Antibody Deficiency Patients Receiving Immunoglobulin Therapy: Data from the US Immunodeficiency Network (USIDNET)"],"prefix":"10.1007","volume":"42","author":[{"given":"Maha N.","family":"Syed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carleigh","family":"Kutac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham-Rundles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramsay L.","family":"Fuleihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrah","family":"Kheradmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-1043","authenticated-orcid":false,"given":"Joud","family":"Hajjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"1317_CR1","doi-asserted-by":"publisher","first-page":"595","DOI":"10.7861\/clinmedicine.9-6-595","volume":"9","author":"P Wood","year":"2009","unstructured":"Wood P. Primary antibody deficiencies: recognition, clinical diagnosis and referral of patients. Clin Med (Lond). 2009;9:595\u20139.","journal-title":"Clin Med (Lond)"},{"key":"1317_CR2","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.crad.2011.10.028","volume":"67","author":"F Hampson","year":"2012","unstructured":"Hampson F, Chandra A, Screaton N, Condliffe A, Kumararatne D, Exley A, et al. Respiratory disease in common variable immunodeficiency and other primary immunodeficiency disorders. Clin Radiol. 2012;67:587\u201395.","journal-title":"Clin Radiol"},{"key":"1317_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1006\/clim.1999.4725","volume":"92","author":"C Cunningham-Rundles","year":"1999","unstructured":"Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92:34\u201348.","journal-title":"Clin Immunol"},{"key":"1317_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13223-015-0092-y","volume":"11","author":"F Jiang","year":"2015","unstructured":"Jiang F, Torgerson TR, Ayars AG. Health-related quality of life in patients with primary immunodeficiency disease. Allergy Asthma Clin Immunol. 2015;11:27.","journal-title":"Allergy Asthma Clin Immunol"},{"key":"1317_CR5","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s10875-016-0279-0","volume":"36","author":"J Routes","year":"2016","unstructured":"Routes J, Costa-Carvalho BT, Grimbacher B, Paris K, Ochs HD, Filipovich A, et al. Health-Related quality of life and health resource utilization in patients with primary immunodeficiency disease prior to and following 12 months of immunoglobulin G treatment. J Clin Immunol. 2016;36:450\u201361.","journal-title":"J Clin Immunol"},{"key":"1317_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1378\/chest.29.1.9","volume":"29","author":"RA Good","year":"1956","unstructured":"Good RA, Mazzitello WF. Chest disease in patients with agammaglobulinemia. Dis Chest. 1956;29:9\u201335.","journal-title":"Dis Chest"},{"key":"1317_CR7","doi-asserted-by":"crossref","unstructured":"Pasteur MC, Bilton D, Hill AT, British Thoracic Society Bronchiectasis non CFGG. British Thoracic Society guideline for non-CF bronchiectasis. Thorax 2010; 65 Suppl 1:i1\u201358.","DOI":"10.1136\/thx.2010.136119"},{"key":"1317_CR8","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/0091-6749(91)90306-9","volume":"88","author":"SK Sweinberg","year":"1991","unstructured":"Sweinberg SK, Wodell RA, Grodofsky MP, Greene JM, Conley ME. Retrospective analysis of the incidence of pulmonary disease in hypogammaglobulinemia. J Allergy Clin Immunol. 1991;88:96\u2013104.","journal-title":"J Allergy Clin Immunol"},{"key":"1317_CR9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1365-2249.2008.03851.x","volume":"155","author":"MD Tarzi","year":"2009","unstructured":"Tarzi MD, Grigoriadou S, Carr SB, Kuitert LM, Longhurst HJ. Clinical immunology review series: an approach to the management of pulmonary disease in primary antibody deficiency. Clin Exp Immunol. 2009;155:147\u201355.","journal-title":"Clin Exp Immunol"},{"key":"1317_CR10","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/S0091-6749(99)70085-0","volume":"104","author":"L Kainulainen","year":"1999","unstructured":"Kainulainen L, Varpula M, Liippo K, Svedstrom E, Nikoskelainen J, Ruuskanen O. Pulmonary abnormalities in patients with primary hypogammaglobulinemia. J Allergy Clin Immunol. 1999;104:1031\u20136.","journal-title":"J Allergy Clin Immunol"},{"key":"1317_CR11","doi-asserted-by":"publisher","unstructured":"Joud H, Nguyen AL, Constantine G, Kutac C, Syed MN, Orange JS, et al. Prophylactic antibiotics versus immunoglobulin replacement in specific antibody deficiency. J Clin Immunol.\u00a02020;40(1):158\u201364. https:\/\/doi.org\/10.1007\/s10875-019-00716-2.","DOI":"10.1007\/s10875-019-00716-2"},{"key":"1317_CR12","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1067\/mai.2002.124999","volume":"109","author":"PJ Busse","year":"2002","unstructured":"Busse PJ, Razvi S, Cunningham-Rundles C. Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency. J Allergy Clin Immunol. 2002;109:1001\u20134.","journal-title":"J Allergy Clin Immunol"},{"key":"1317_CR13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1440-1843.2009.01679.x","volume":"15","author":"A Aghamohammadi","year":"2010","unstructured":"Aghamohammadi A, Allahverdi A, Abolhassani H, Moazzami K, Alizadeh H, Gharagozlou M, et al. Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia. Respirology. 2010;15:289\u201395.","journal-title":"Respirology"},{"key":"1317_CR14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s10875-011-9511-0","volume":"31","author":"I Quinti","year":"2011","unstructured":"Quinti I, Soresina A, Guerra A, Rondelli R, Spadaro G, Agostini C, et al. Effectiveness of immunoglobulin replacement therapy on clinical outcome in patients with primary antibody deficiencies: results from a multicenter prospective cohort study. J Clin Immunol. 2011;31:315\u201322.","journal-title":"J Clin Immunol"},{"issue":"1354\u201360","key":"1317_CR15","volume":"125","author":"M Lucas","year":"2010","unstructured":"Lucas M, Lee M, Lortan J, Lopez-Granados E, Misbah S, Chapel H. Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years. J Allergy Clin Immunol. 2010;125(1354\u201360): e4.","journal-title":"J Allergy Clin Immunol"},{"key":"1317_CR16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jaip.2013.09.013","volume":"1","author":"M Kuruvilla","year":"2013","unstructured":"Kuruvilla M, de la Morena MT. Antibiotic prophylaxis in primary immune deficiency disorders. J Allergy Clin Immunol Pract. 2013;1:573\u201382.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"1317_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/B978-012088770-5\/50045-9","volume-title":"Statistics in Medicine","author":"RH Riffenburgh","year":"2006","unstructured":"Riffenburgh RH. Chapter 6 - statistical testing, risks, and odds in medical decisions. In: Riffenburgh RH, editor. Statistics in Medicine. 2nd ed. Burlington: Academic Press; 2006. p. 93\u2013114.","edition":"2"},{"key":"1317_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fped.2014.00077","volume":"2","author":"M Jesenak","year":"2014","unstructured":"Jesenak M, Banovcin P, Jesenakova B, Babusikova E. Pulmonary manifestations of primary immunodeficiency disorders in children. Front Pediatr. 2014;2:77.","journal-title":"Front Pediatr"},{"key":"1317_CR19","doi-asserted-by":"publisher","first-page":"5308","DOI":"10.1016\/j.vaccine.2007.05.021","volume":"25","author":"N Rezaei","year":"2007","unstructured":"Rezaei N, Aghamohammadi A, Siadat SD, Nejati M, Ahmadi H, Moin M, et al. Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies. Vaccine. 2007;25:5308\u201314.","journal-title":"Vaccine"},{"key":"1317_CR20","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/cid\/ciu646","volume":"59","author":"C Aguilar","year":"2014","unstructured":"Aguilar C, Malphettes M, Donadieu J, Chandesris O, Coignard-Biehler H, Catherinot E, et al. Prevention of infections during primary immunodeficiency. Clin Infect Dis. 2014;59:1462\u201370.","journal-title":"Clin Infect Dis"},{"key":"1317_CR21","first-page":"31","volume":"86","author":"RA Hermaszewski","year":"1993","unstructured":"Hermaszewski RA, Webster AD. Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications. Q J Med. 1993;86:31\u201342.","journal-title":"Q J Med"},{"key":"1317_CR22","first-page":"1158","volume":"11","author":"MG Mikolajczyk","year":"2004","unstructured":"Mikolajczyk MG, Concepcion NF, Wang T, Frazier D, Golding B, Frasch CE, et al. Characterization of antibodies to capsular polysaccharide antigens of Haemophilus influenzae type b and Streptococcus pneumoniae in human immune globulin intravenous preparations. Clin Diagn Lab Immunol. 2004;11:1158\u201364.","journal-title":"Clin Diagn Lab Immunol"},{"key":"1317_CR23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/trf.13869","volume":"57","author":"S Lee","year":"2017","unstructured":"Lee S, Kim HW, Kim KH. Functional antibodies to Haemophilus influenzae type B, Neisseria meningitidis, and Streptococcus pneumoniae contained in intravenous immunoglobulin products. Transfusion. 2017;57:157\u201365.","journal-title":"Transfusion"},{"key":"1317_CR24","unstructured":"Bonilla FA, Khan DA, Ballas ZK, Chinen J, Frank MM, Hsu JT, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol 2015; 136:1186\u2013205.e1\u201378."},{"key":"1317_CR25","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jaci.2010.04.016","volume":"126","author":"L Kainulainen","year":"2010","unstructured":"Kainulainen L, Vuorinen T, Rantakokko-Jalava K, Osterback R, Ruuskanen O. Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia. J Allergy Clin Immunol. 2010;126:120\u20136.","journal-title":"J Allergy Clin Immunol"},{"key":"1317_CR26","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.jaci.2010.02.040","volume":"125","author":"M Lucas","year":"2010","unstructured":"Lucas M, Lee M, Lortan J, Lopez-Granados E, Misbah S, Chapel H. Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years. J Allergy Clin Immunol. 2010;125:1354-60.e4.","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"1317_CR27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/cei.12748","volume":"184","author":"J Brent","year":"2016","unstructured":"Brent J, Guzman D, Bangs C, Grimbacher B, Fayolle C, Huissoon A, et al. Clinical and laboratory correlates of lung disease and cancer in adults with idiopathic hypogammaglobulinaemia. Clin Exp Immunol. 2016;184:73\u201382.","journal-title":"Clin Exp Immunol"},{"key":"1317_CR28","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.mayocp.2013.05.021","volume":"88","author":"SH Urm","year":"2013","unstructured":"Urm SH, Yun HD, Fenta YA, Yoo KH, Abraham RS, Hagan J, et al. Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study. Mayo Clin Proc. 2013;88:813\u201321.","journal-title":"Mayo Clin Proc"},{"key":"1317_CR29","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jaci.2008.07.029","volume":"122","author":"YJ Juhn","year":"2008","unstructured":"Juhn YJ, Kita H, Yawn BP, Boyce TG, Yoo KH, McGree ME, et al. Increased risk of serious pneumococcal disease in patients with asthma. J Allergy Clin Immunol. 2008;122:719\u201323.","journal-title":"J Allergy Clin Immunol"},{"key":"1317_CR30","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1136\/jclinpath-2015-203351","volume":"69","author":"GK Wong","year":"2016","unstructured":"Wong GK, Huissoon AP. T-cell abnormalities in common variable immunodeficiency: the hidden defect. J Clin Pathol. 2016;69:672\u20136.","journal-title":"J Clin Pathol"},{"key":"1317_CR31","doi-asserted-by":"crossref","unstructured":"Paquin-Proulx D, Sandberg JK. Persistent immune activation in CVID and the role of IVIg in its suppression. Front Immunol\u00a02014; 5:637-.","DOI":"10.3389\/fimmu.2014.00637"},{"key":"1317_CR32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10875-018-0476-0","volume":"38","author":"MG Lawrence","year":"2018","unstructured":"Lawrence MG, Palacios-Kibler TV, Workman LJ, Schuyler AJ, Steinke JW, Payne SC, et al. Low serum IgE is a sensitive and specific marker for common variable immunodeficiency (CVID). J Clin Immunol. 2018;38:225\u201333.","journal-title":"J Clin Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01317-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-022-01317-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01317-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T19:21:37Z","timestamp":1668799297000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-022-01317-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["1317"],"URL":"https:\/\/doi.org\/10.1007\/s10875-022-01317-2","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]},"assertion":[{"value":"22 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the USIDNET Steering Committee and the Baylor College of Medicine Institutional Review Board (IRB).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Hajjar received grants from Immune Deficiency Foundation, the US immunodeficiency network, the Chao-physician Scientist award, the Texas Medical Center Digestive Diseases Center, and the Jeffrey Modell Foundation. J. Hajjar received an honorarium\/advisory from Horizon, Pharming, Baxalta, CSL Behring, the National guard, and Al-Faisal University Hospital outside the submitted work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}