{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:18:36Z","timestamp":1787584716282,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s10875-022-01330-5","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T11:05:32Z","timestamp":1657883132000},"page":"1660-1671","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Algerian Registry for Inborn Errors of Immunity in Children: Report of 887 Children (1985\u20132021)"],"prefix":"10.1007","volume":"42","author":[{"given":"Abdelghani","family":"Yagoubi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzeddine","family":"Tahiat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila Souad","family":"Touri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Samir","family":"Ladj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouardia","family":"Drali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahim","family":"Belaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayda","family":"Mohand-Oussaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhak","family":"Dehimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"Belbouab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacine","family":"Ferhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souhila","family":"Melzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Guedouar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliha","family":"Hakem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouardia","family":"Khemici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacine","family":"Inouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanis","family":"Meddour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadeddine","family":"Dib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohra","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Iddir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahmane","family":"Boufersaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"Boudiaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrachid","family":"Bouhdjila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouardia","family":"Ibsaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hachemi","family":"Maouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djazia","family":"Dahlouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzedine","family":"Mekki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belkacem","family":"Bioud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zair","family":"Bouzerar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoulikha","family":"Zeroual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadila","family":"Benhassine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahila","family":"Bekkat-Berkani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumeya","family":"Naamoune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir Sofiane","family":"Salah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Chaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Attal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Bensaadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadira","family":"Bouchair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacira","family":"Cherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Kedji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih","family":"Bendeddouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Lamine","family":"Atif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Djenouhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Kechout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"Djidjik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keltoum Nafissa","family":"Benhalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Smati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1833-8002","authenticated-orcid":false,"given":"Rachida","family":"Boukari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"1330_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s10875-019-00737-x","volume":"40","author":"SG Tangye","year":"2020","unstructured":"Tangye SG, Al-Herz W, Bousfiha A, Chatila T, Cunningham-Rundles C, Etzioni A, et al. Human inborn errors of immunity: 2019 update on the classification from the international union of immunological societies expert committee. J Clin Immunol. 2020;40:24\u201364.","journal-title":"J Clin Immunol"},{"key":"1330_CR2","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1007\/s10875-021-00980-1","volume":"41","author":"SG Tangye","year":"2021","unstructured":"Tangye SG, Al-Herz W, Bousfiha A, Cunningham-Rundles C, Franco JL, Holland SM, et al. The ever-increasing array of novel inborn errors of immunity: an interim update by the IUIS committee. J Clin Immunol. 2021;41:666\u201379.","journal-title":"J Clin Immunol"},{"key":"1330_CR3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.iac.2020.03.002","volume":"40","author":"JP Lopes","year":"2020","unstructured":"Lopes JP, Cunningham-Rundles C. The importance of primary immunodeficiency registries. The United States immunodeficiency network registry. Immunol Allergy Clin N Am. 2020;40:385\u2013402.","journal-title":"Immunol Allergy Clin N Am"},{"key":"1330_CR4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.patbio.2014.04.002","volume":"62","author":"A Tahiat","year":"2014","unstructured":"Tahiat A, Djidjik R, Boushaki S, Cherguelaine K, Gharnaout M, Boumedine S, et al. Common variable immunodeficiency (CVID): clinical and immunological features of 29 Algerian patients. Pathol Biol. 2014;62:377\u201381.","journal-title":"Pathol Biol"},{"key":"1330_CR5","doi-asserted-by":"publisher","unstructured":"Djidjik R, Messaoudani N, Tahiat A, Meddour Y, Chaib S, Atek A et al. Clinical, immunological and genetic features in eleven Algerian patients with major histocompatibility complex class II expression deficiency. Allerg Asthma Clin Immunol (2012). https:\/\/doi.org\/10.1186\/17101492-8-14","DOI":"10.1186\/17101492-8-14"},{"issue":"S1","key":"1330_CR6","first-page":"S22","volume":"4","author":"N Kechout","year":"2015","unstructured":"Kechout N, Attal N, Kaddache C, Touri N, Smati L, Benhalla NK, et al. MHCII deficiency: clinical and molecular findings. Rev Alg Immunol Immunopath. 2015;4(S1):S22\u20136.","journal-title":"Rev Alg Immunol Immunopath"},{"key":"1330_CR7","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.clim.2015.09.011","volume":"161","author":"S Boushaki","year":"2015","unstructured":"Boushaki S, Tahiat A, Meddour Y, Chan KW, Chaib S, Benhalla N, et al. Prevalence of BTK mutations in male Algerian patterns with agammaglobulinemia and severe B cell lymphopenia. Clin Immunol. 2015;161:286\u201390.","journal-title":"Clin Immunol"},{"key":"1330_CR8","doi-asserted-by":"publisher","unstructured":"Kechout N, Touri N, Saidani K, Dehimi A, Ladj S, Ferhani Y et al. Leukocyte adhesion deficiency type 1 in Algeria. Meta gene (2020). https:\/\/doi.org\/10.1016\/j.mgene.2020.100746","DOI":"10.1016\/j.mgene.2020.100746"},{"key":"1330_CR9","doi-asserted-by":"publisher","unstructured":"Tahiat A, Yagoubi A, Ladj MS, Belbouab R, Aggoune S, Atek L et al. Diagnostic and predictive contribution of autoantibodies screening in a large series of patients with primary immunodeficiencies. Front Immunol (2021). https:\/\/doi.org\/10.3389\/fimmu.2021.665322","DOI":"10.3389\/fimmu.2021.665322"},{"key":"1330_CR10","unstructured":"National office of statistics. https:\/\/www.ons.dz\/"},{"issue":"S1","key":"1330_CR11","first-page":"S9","volume":"4","author":"M Baghriche","year":"2015","unstructured":"Baghriche M, Smati L, Yagoubi A, Benhalla KN, Kaddache C, Cherif N, et al. Introduction to primary immunodeficiency diseases in Algeria. Rev Alg Immunol Immunopath. 2015;4(S1):S9\u201313.","journal-title":"Rev Alg Immunol Immunopath"},{"key":"1330_CR12","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.jaip.2019.02.004","volume":"7","author":"MG Seidel","year":"2019","unstructured":"Seidel MG, Kindle G, Gathmann B, Quinti I, Buckland M, van Montfrans J, et al. The European Society for Immunodeficiencies (ESID) Registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract. 2019;7:1763\u201370. https:\/\/doi.org\/10.1016\/j.jaip.2019.02.004.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"1330_CR13","unstructured":"ESID Registry-working definitions for clinical diagnosis of PID. 2014. https:\/\/esid.org\/Working-Parties\/Registry-Working-Party\/Diagnosis-criteria."},{"key":"1330_CR14","doi-asserted-by":"publisher","unstructured":"Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Conley ME, Cunningham-Rundles C et al. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol (2014). https:\/\/doi.org\/10.3389\/fimmu.2014.00162","DOI":"10.3389\/fimmu.2014.00162"},{"key":"1330_CR15","doi-asserted-by":"publisher","unstructured":"Aghamohammadi A, Rezaei N, Yazdani R, Delavari S, Kutukculer N, Topyildiz E et al. Consensus Middle East and North Africa registry on inborn errors of immunity. J Clin Immunol (2021).  https:\/\/doi.org\/10.1007\/s10875-021-01053-z","DOI":"10.1007\/s10875-021-01053-z"},{"key":"1330_CR16","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1080\/1744666X.2020.1801422","volume":"16","author":"H Abolhassani","year":"2020","unstructured":"Abolhassani H, Azizi G, Sharifi L, Yazdani R, Mohsenzadegan M, Delavari S, et al. Global systematic review of primary immunodeficiency registries. Exp Rev Clin Immunol. 2020;16:717\u201332.","journal-title":"Exp Rev Clin Immunol"},{"key":"1330_CR17","first-page":"459","volume":"34","author":"A Bousfiha","year":"2014","unstructured":"Bousfiha A, Jeddane L, El Hafidi N, Benajiba N, Rada N, El Bakkouri J, et al. First report of the Moroccan registry of primary immunodeficiencies: 15 years of experience (1998\u20132012). J Clin Immunol. 2014;34:459\u201368.","journal-title":"J Clin Immunol"},{"key":"1330_CR18","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s10875-015-0206-9","volume":"35","author":"F Mellouli","year":"2015","unstructured":"Mellouli F, Ben Mustapha I, Ben Khaled M, Besbes H, Ouederni M, Mekki N, et al. Report of the Tunisian registry of primary immunodeficiencies: 25 years of experience (1988\u20132012). J Clin Immunol. 2015;35:745\u201353.","journal-title":"J Clin Immunol"},{"key":"1330_CR19","first-page":"672","volume":"96","author":"A Bousfiha","year":"2018","unstructured":"Bousfiha A, Errami A, Jeddane L, Mellouli F, Reda SM, Adeli M, et al. Primary immunodeficiencies: epidemiology in the Maghreb. Tunis Med. 2018;96:672\u20137.","journal-title":"Tunis Med"},{"key":"1330_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10875-012-9751-7","volume":"33","author":"A Bousfiha","year":"2013","unstructured":"Bousfiha A, Jeddane L, Ailal F, Benhsaien I, Mahlaoui N, Casanova JL, et al. Primary immunodeficiency diseases worldwide: more common than generally thought. J Clin Immunol. 2013;33:1\u20137.","journal-title":"J Clin Immunol"},{"key":"1330_CR21","first-page":"435","volume":"41","author":"A Benallegue","year":"1984","unstructured":"Benallegue A, Kedji F. Consanguinity and public health. An Algerian study Arch frP\u00e9diatr. 1984;41:435\u201340.","journal-title":"An Algerian study Arch frP\u00e9diatr"},{"key":"1330_CR22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s10875-016-0314-1","volume":"36","author":"N Galal","year":"2016","unstructured":"Galal N, Meshaal S, El-Hawary R, Abdelaziz D, Alkady R, Lotfy S, et al. Patterns of primary immunodeficiency disorders among a highly consanguineous population: Cairo university pediatric hospital\u2019s 5-year experience. J Clin Immunol. 2016;36:649\u201355.","journal-title":"J Clin Immunol"},{"key":"1330_CR23","doi-asserted-by":"publisher","unstructured":"Al-Herz W, Al-Ahmed M, Al-Khabaz A, Husain A, Sadek A, Othman Y. The Kuwait national primary immunodeficiency registry 2004\u20132018. Front Immunol (2019). https:\/\/doi.org\/10.3389\/fimmu.2019.01754","DOI":"10.3389\/fimmu.2019.01754"},{"key":"1330_CR24","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s10875-015-0197-6","volume":"35","author":"B Al-Saud","year":"2015","unstructured":"Al-Saud B, Al-Mousa H, Al-Gazlan S, Al-Ghonaium A, Arnaout R, Al-Seraihy A, et al. Primary immunodeficiency diseases in Saudi Arabia: a tertiary care hospital experience over a period of three years (2010\u20132013). J Clin Immunol. 2015;35:651\u201360.","journal-title":"J Clin Immunol"},{"key":"1330_CR25","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1007\/s10875-018-0556-1","volume":"38","author":"H Abolhassani","year":"2018","unstructured":"Abolhassani H, Kiaee F, Tavakol M, Chavoshzadeh Z, Mahdaviani SA, Moomen T, et al. Fourth update on the Iranian national registry of primaryimmunodeficiencies: integration of molecular diagnosis. J Clin Immunol. 2018;38:816\u201332.","journal-title":"J Clin Immunol"},{"key":"1330_CR26","unstructured":"[Cited: Sept 22 2021]. https:\/\/cci-reporting.uniklinik-freiburg.de\/#\/"},{"key":"1330_CR27","unstructured":"[Cited: Sept 22 2021]. https:\/\/lasidregistry.org\/view\/statistics\/general\/2021-08"},{"key":"1330_CR28","unstructured":"[Cited: Sept 22 2021]. https:\/\/usidnet.org\/registry-data\/stats-registry-enrollment\/"},{"key":"1330_CR29","doi-asserted-by":"publisher","first-page":"5108","DOI":"10.1182\/blood-2011-05-352716","volume":"118","author":"M Ouederni","year":"2011","unstructured":"Ouederni M, Vincent QB, Frange P, Touzot F, Scerra S, Bejaoui M, et al. Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients. Blood. 2011;118:5108\u201318.","journal-title":"Blood"},{"key":"1330_CR30","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/cid\/ciu646","volume":"59","author":"C Aguilar","year":"2014","unstructured":"Aguilar C, Malphettes M, Donadieu J, Chandesris O, Coignard H, Catherinot E, et al. Prevention of infections during primary immunodeficiency. Clin Infect Dis. 2014;59:1462\u201370.","journal-title":"Clin Infect Dis"},{"key":"1330_CR31","doi-asserted-by":"publisher","unstructured":"Castagnoli R, Delmonte O.M, Calzoni E, Notarangelo L.D. Hematopoietic stem cell transplantation in primary immunodeficiency diseases: current status and future perspectives. Front Pediatr (2019). https:\/\/doi.org\/10.3389\/fped.2019.0029","DOI":"10.3389\/fped.2019.0029"},{"key":"1330_CR32","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10875-008-9260-x","volume":"29","author":"SM Reda","year":"2009","unstructured":"Reda SM, Afifi HM, Amine MM. Primary immunodeficiency diseases in Egyptian children: a single-center study. J Clin Immunol. 2009;29:343\u201351.","journal-title":"J Clin Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01330-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-022-01330-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01330-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T20:32:09Z","timestamp":1669408329000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-022-01330-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["1330"],"URL":"https:\/\/doi.org\/10.1007\/s10875-022-01330-5","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"assertion":[{"value":"9 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involving human participants was reviewed and approved by Local Ethics Committee of Mustapha Bacha University Hospital and it conforms to the provisions of the World Medical Association\u2019s Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent to participate in this study was provided by the participants\u2019 parent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All the authors read and approved the final manuscript and consented for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}