{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:35:34Z","timestamp":1793500534966,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3G0811"],"award-info":[{"award-number":["CMRPG3G0811"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3L0961"],"award-info":[{"award-number":["CMRPG3L0961"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST104-2314-B-182A-042"],"award-info":[{"award-number":["MOST104-2314-B-182A-042"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST105-2314-B-182A-033"],"award-info":[{"award-number":["MOST105-2314-B-182A-033"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST109-2628-B-182-014"],"award-info":[{"award-number":["MOST109-2628-B-182-014"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST110-2628-B-182-018"],"award-info":[{"award-number":["MOST110-2628-B-182-018"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s10875-022-01341-2","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T06:02:48Z","timestamp":1660111368000},"page":"1730-1741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cryptococcus gattii Infection as the Major Clinical Manifestation in Patients with Autoantibodies Against Granulocyte\u2013Macrophage Colony-Stimulating Factor"],"prefix":"10.1007","volume":"42","author":[{"given":"Shang-Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fang","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Po","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Wang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Fu","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhan-Jie","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Ting","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Hsi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsin","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih-Shinn","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Aoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Huei","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ya","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chi","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Ning","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Hua","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Te","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0643-2256","authenticated-orcid":false,"given":"Cheng-Lung","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"issue":"32","key":"1341_CR1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1146\/annurev-immunol-032713-120222","volume":"1","author":"SK Browne","year":"2014","unstructured":"Browne SK. Anticytokine autoantibody-associated immunodeficiency. Annu Rev Immunol. 2014;1(32):635\u201357.","journal-title":"Annu Rev Immunol"},{"issue":"6\u20137","key":"1341_CR2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00439-020-02180-0","volume":"139","author":"CL Ku","year":"2020","unstructured":"Ku CL, Chi CY, von Bernuth H, Doffinger R. Autoantibodies against cytokines: phenocopies of primary immunodeficiencies? Hum Genet. 2020;139(6\u20137):783\u201394.","journal-title":"Hum Genet"},{"issue":"6","key":"1341_CR3","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.autrev.2015.01.015","volume":"14","author":"T Vincent","year":"2015","unstructured":"Vincent T, Plawecki MM, Goulabchand R, Guilpain P, Eliaou JFF. Emerging clinical phenotypes associated with anti-cytokine autoantibodies. Autoimmun Rev. 2015;14(6):528\u201335.","journal-title":"Autoimmun Rev"},{"key":"1341_CR4","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.coi.2021.05.007","volume":"72","author":"HP Shih","year":"2021","unstructured":"Shih HP, Ding JY, Yeh CF, Chi CY, Ku CL. Anti-interferon-\u03b3 autoantibody-associated immunodeficiency. Curr Opin Immunol. 2021;72:206\u201314.","journal-title":"Curr Opin Immunol"},{"issue":"4\u20135","key":"1341_CR5","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.autrev.2014.01.046","volume":"13","author":"I Ben-Dov","year":"2014","unstructured":"Ben-Dov I, Segel MJ. Autoimmune pulmonary alveolar proteinosis: clinical course and diagnostic criteria. Autoimmun Rev. 2014;13(4\u20135):513\u20137.","journal-title":"Autoimmun Rev"},{"issue":"6","key":"1341_CR6","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1084\/jem.190.6.875","volume":"190","author":"T Kitamura","year":"1999","unstructured":"Kitamura T, Tanaka N, Watanabe J, Uchida K, Kanegasaki S, Yamada Y, et al. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte\/macrophage colony-stimulating factor. J Exp Med. 1999;190(6):875\u201380.","journal-title":"J Exp Med"},{"key":"1341_CR7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13023-014-0171-z","volume":"9","author":"J Hildebrandt","year":"2014","unstructured":"Hildebrandt J, Yalcin E, Bresser H-G, Cinel G, Gappa M, Haghighi A, et al. Characterization of CSF2RA mutation related juvenile pulmonary alveolar proteinosis. Orphanet J Rare Dis. 2014;9:171.","journal-title":"Orphanet J Rare Dis"},{"key":"1341_CR8","doi-asserted-by":"crossref","unstructured":"Suzuki T, Maranda B, Sakagami T, Catellier P, Couture C-Y, Carey BC, et al. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations. Vol. 37, The European respiratory journal. England; 2011. p. 201\u20134.","DOI":"10.1183\/09031936.00090610"},{"issue":"3","key":"1341_CR9","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1182\/blood-2003-05-1565","volume":"103","author":"K Uchida","year":"2004","unstructured":"Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, et al. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood. 2004;103(3):1089\u201398.","journal-title":"Blood"},{"issue":"4","key":"1341_CR10","first-page":"1","volume":"7","author":"SE Morales-L\u00f3pez","year":"2021","unstructured":"Morales-L\u00f3pez SE, Garcia-Effron G. Infections due to rare Cryptococcus species. A literature review J Fungi. 2021;7(4):1\u201320.","journal-title":"A literature review J Fungi"},{"key":"1341_CR11","doi-asserted-by":"crossref","unstructured":"Tseng HK, Liu CP, Ho MW, Lu PL, Lo HJ, Lin YH, et al. Microbiological, epidemiological, and clinical characteristics and outcomes of patients with cryptococcosis in Taiwan, 1997\u20132010. PLoS One. 2013;8(4).","DOI":"10.1371\/journal.pone.0061921"},{"issue":"8","key":"1341_CR12","doi-asserted-by":"publisher","first-page":"3959","DOI":"10.4049\/jimmunol.1202526","volume":"190","author":"LB Rosen","year":"2013","unstructured":"Rosen LB, Freeman AF, Yang LM, Jutivorakool K, Olivier KN, Angkasekwinai N, et al. Anti\u2013GM-CSF autoantibodies in patients with cryptococcal Meningitis. J Immunol. 2013;190(8):3959\u201366.","journal-title":"J Immunol"},{"issue":"2","key":"1341_CR13","doi-asserted-by":"publisher","first-page":"e00912","DOI":"10.1128\/mBio.00912-14","volume":"5","author":"T Saijo","year":"2014","unstructured":"Saijo T, Chen J, Chen SC-ACA, Rosen LB, Yi J, Sorrell TC, et al. Anti-granulocyte-macrophage colony-stimulating factor autoantibodies are a risk factor for central nervous system infection by Cryptococcus gattii in otherwise immunocompetent patients. MBio. 2014;5(2):e00912-14.","journal-title":"MBio"},{"issue":"2","key":"1341_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10875-016-0364-4","volume":"37","author":"C-YC-Y Kuo","year":"2017","unstructured":"Kuo C-YC-Y, Wang S-YS-Y, Shih H-PH-PH-P, Tu K-HK-H, Huang W-CW-CW-C, Ding J-YJ-Y, et al. Disseminated cryptococcosis due to anti-granulocyte-macrophage colony-stimulating factor autoantibodies in the absence of pulmonary alveolar proteinosis. J Clin Immunol. 2017;37(2):143\u201352.","journal-title":"J Clin Immunol"},{"issue":"4","key":"1341_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ofid\/ofx211","volume":"4","author":"NF Crum-Cianflone","year":"2017","unstructured":"Crum-Cianflone NF, Lam PV, Ross-Walker S, Rosen LB, Holland SM. Autoantibodies to granulocyte-macrophage colony-stimulating factor associated with severe and unusual manifestations of Cryptococcus gattii infections. Open Forum Infect Dis. 2017;4(4):1\u20136.","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"1341_CR16","doi-asserted-by":"publisher","first-page":"e02733","DOI":"10.1128\/mBio.02733-18","volume":"10","author":"S Applen Clancey","year":"2019","unstructured":"Applen Clancey S, Ciccone EJ, Coelho MA, Davis J, Ding L, Betancourt R, et al. Cryptococcus deuterogattii vgiia infection associated with travel to the pacific northwest outbreak region in an anti- granulocyte-macrophage colony-stimulating factor autoantibody-positive patient in the united states. MBio. 2019;10(1):e02733-e2818.","journal-title":"MBio"},{"key":"1341_CR17","unstructured":"Kuo PH, Wu UI, Pan YH, Wang JT, Wang YC, Sun HY, et al. Neutralizing anti-GM-CSF autoantibodies in patients with CNS and localized cryptococcosis: a longitudinal follow-up and literature review. Clin Infect Dis. 2021; ciab920."},{"issue":"5","key":"1341_CR18","doi-asserted-by":"publisher","first-page":"e0270821","DOI":"10.1128\/mBio.02708-21","volume":"12","author":"DH Yang","year":"2021","unstructured":"Yang DH, England MR, Salvator H, Anjum S, Park YD, Marr KA, et al. Cryptococcus gattii species complex as an opportunistic pathogen: underlying medical conditions associated with the infection. MBio. 2021;12(5):e0270821.","journal-title":"MBio"},{"issue":"7","key":"1341_CR19","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/cid\/ciu968","volume":"60","author":"LB Rosen","year":"2015","unstructured":"Rosen LB, Rocha Pereira N, Figueiredo C, Fiske LC, Ressner RA, Hong JC, et al. Nocardia-induced granulocyte macrophage colony-stimulating factor is neutralized by autoantibodies in disseminated\/extrapulmonary nocardiosis. Clin Infect Dis. 2015;60(7):1017\u201325.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"1341_CR20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.clim.2010.02.017","volume":"135","author":"B Carey","year":"2010","unstructured":"Carey B, Trapnell BC. The molecular basis of pulmonary alveolar proteinosis. Clin Immunol. 2010;135(2):223\u201335.","journal-title":"Clin Immunol"},{"issue":"2","key":"1341_CR21","first-page":"200","volume":"3","author":"WT Lim","year":"2021","unstructured":"Lim WT, Mudalige S, Nilushi T, Shanka J, Parakrama K. Crazy-paving pattern: a rare case of autoimmune pulmonary alveolar proteinosis (PAP) with positive anti-GM-CSF antibody following cryptococcal infection in an otherwise healthy individual and review of literature. Eur J Respir Med. 2021;3(2):200\u20135.","journal-title":"Eur J Respir Med"},{"issue":"6","key":"1341_CR22","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","volume":"71","author":"J Peter Donnelly","year":"2020","unstructured":"Peter Donnelly J, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, et al. Revision and update of the consensus definitions of invasive fungal disease from the European organization for research and treatment of cancer and the mycoses study group education and research consortium. Clin Infect Dis. 2020;71(6):1367\u201376.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"1341_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.idc.2015.10.006","volume":"30","author":"EK Maziarz","year":"2016","unstructured":"Maziarz EK, Perfect JR. Cryptococcosis. Infect Dis Clin North Am. 2016;30(1):179\u2013206.","journal-title":"Infect Dis Clin North Am"},{"issue":"7","key":"1341_CR24","first-page":"4335","volume":"14","author":"FW Quelle","year":"1994","unstructured":"Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, et al. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol. 1994;14(7):4335\u201341.","journal-title":"Mol Cell Biol"},{"issue":"6","key":"1341_CR25","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1002\/j.1460-2075.1995.tb07100.x","volume":"14","author":"AL Mui","year":"1995","unstructured":"Mui AL, Wakao H, O\u2019Farrell AM, Harada N, Miyajima A. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995;14(6):1166\u201375.","journal-title":"EMBO J"},{"issue":"2","key":"1341_CR26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/jcp.1041400219","volume":"140","author":"T Kitamura","year":"1989","unstructured":"Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, et al. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol. 1989;140(2):323\u201334.","journal-title":"J Cell Physiol"},{"issue":"5","key":"1341_CR27","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.jinf.2016.01.016","volume":"72","author":"KH Lin","year":"2016","unstructured":"Lin KH, Chen CM, Chen TL, Kuo SC, Kao CC, Jeng YC, et al. Diabetes mellitus is associated with acquisition and increased mortality in HIV-uninfected patients with cryptococcosis: a population-based study. J Infect. 2016;72(5):608\u201314.","journal-title":"J Infect"},{"issue":"3","key":"1341_CR28","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.jaci.2015.09.018","volume":"137","author":"CL Ku","year":"2016","unstructured":"Ku CL, Lin CH, Chang SW, Chu CC, Chan JFW, Kong XF, et al. Anti\u2013IFN-\u03b3 autoantibodies are strongly associated with HLA-DR*15:02\/16:02 and HLA-DQ*05:01\/05:02 across Southeast Asia. J Allergy Clin Immunol. 2016;137(3):945-948.e8.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1341_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1371\/journal.pone.0016635","volume":"6","author":"PL Chen","year":"2011","unstructured":"Chen PL, Fann CSJ, Chu CC, Chang CC, Chang SW, Hsieh HY, et al. Comprehensive genotyping in two homogeneous Graves\u2019 disease samples reveals major and novel HLA association alleles. PLoS\u00a0One. 2011;6(1):10\u20134.","journal-title":"PLoS ONE"},{"issue":"8","key":"1341_CR30","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1182\/blood-2012-08-452482","volume":"121","author":"CY Chi","year":"2013","unstructured":"Chi CY, Chu CC, Liu JP, Lin CH, Ho MW, Lo WJ, et al. Anti-IFN-gamma autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood. 2013;121(8):1357\u201366.","journal-title":"Blood"},{"issue":"1","key":"1341_CR31","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/s41467-021-21011-y","volume":"12","author":"S Sakaue","year":"2021","unstructured":"Sakaue S, Yamaguchi E, Inoue Y, Takahashi M, Hirata J, Suzuki K, et al. Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis. Nat Commun. 2021;12(1):1032.","journal-title":"Nat Commun"},{"key":"1341_CR32","doi-asserted-by":"publisher","first-page":"7375","DOI":"10.1038\/ncomms8375","volume":"6","author":"L Piccoli","year":"2015","unstructured":"Piccoli L, Campo I, Fregni CS, Rodriguez BMF, Minola A, Sallusto F, et al. Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis. Nat Commun. 2015;6:7375.","journal-title":"Nat Commun"},{"issue":"3","key":"1341_CR33","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1128\/IAI.00274-06","volume":"75","author":"FL Wormley","year":"2007","unstructured":"Wormley FL, Perfect JR, Steele C, Cox GM. Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Infect Immun. 2007;75(3):1453\u201362.","journal-title":"Infect Immun"},{"issue":"3","key":"1341_CR34","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1128\/IAI.73.3.1788-1796.2005","volume":"73","author":"GH Chen","year":"2005","unstructured":"Chen GH, McDonald RA, Wells JC, Huffnagle GB, Lukacs NW, Toews GB. The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans. Infect Immun. 2005;73(3):1788\u201396.","journal-title":"Infect Immun"},{"issue":"1","key":"1341_CR35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.7883\/yoken.JJID.2015.340","volume":"70","author":"P Chetchotisakd","year":"2017","unstructured":"Chetchotisakd P, Anunnatsiri S, Nithichanon A, Lertmemongkolchai G. Cryptococcosis in anti-interferon-gamma autoantibody-positive patients: a different clinical manifestation from HIV-infected patients. Jpn J Infect Dis. 2017;70(1):69\u201374.","journal-title":"Jpn J Infect Dis"},{"issue":"25","key":"1341_CR36","doi-asserted-by":"publisher","first-page":"e3927","DOI":"10.1097\/MD.0000000000003927","volume":"95","author":"CY Chi","year":"2016","unstructured":"Chi CY, Lin CH, Ho MW, Ding JY, Huang WC, Shih HP, et al. Clinical manifestations, course, and outcome of patients with neutralizing anti-interferon-\u03b3 autoantibodies and disseminated nontuberculous mycobacterial infections. Medicine (Baltimore). 2016;95(25):e3927.","journal-title":"Medicine (Baltimore)"},{"key":"1341_CR37","first-page":"1","volume":"8","author":"TL de Souza","year":"2017","unstructured":"de Souza TL, de SC Fernandes RC, da Silva JA, Alves VG, Coelho AG, Faria ACS, et al. Microbial disease spectrum linked to a novel IL-12R\u03b21 N-terminal signal peptide stop-gain homozygous mutation with paradoxical receptor cell-surface expression. Front Microbiol. 2017;8:1\u201310.","journal-title":"Front Microbiol"},{"issue":"7","key":"1341_CR38","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1177\/1535370218764086","volume":"243","author":"J Wipasa","year":"2018","unstructured":"Wipasa J, Chaiwarith R, Chawansuntati K, Praparattanapan J, Rattanathammethee K, Supparatpinyo K. Characterization of anti-interferon-\u03b3 antibodies in HIV-negative immunodeficient patients infected with unusual intracellular microorganisms. Exp Biol Med. 2018;243(7):621\u20136.","journal-title":"Exp Biol Med"},{"issue":"10","key":"1341_CR39","doi-asserted-by":"publisher","first-page":"4994","DOI":"10.1128\/IAI.66.10.4994-5000.1998","volume":"66","author":"K Decken","year":"1998","unstructured":"Decken K, K\u00f6hler G, Palmer-Lehmann K, Wunderlin A, Mattner F, Magram J, et al. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun. 1998;66(10):4994\u20135000.","journal-title":"Infect Immun"},{"issue":"1","key":"1341_CR40","first-page":"79","volume":"30","author":"O Jirapongsananuruk","year":"2012","unstructured":"Jirapongsananuruk O, Luangwedchakarn V, Niemela JE, Pacharn P, Visitsunthorn N, Thepthai C, et al. Cryptococcal osteomyelitis in a child with a novel compound mutation of the IL12RB1 gene. Asian Pacific J allergy Immunol. 2012;30(1):79\u201382.","journal-title":"Asian Pacific J allergy Immunol"},{"key":"1341_CR41","doi-asserted-by":"crossref","unstructured":"Rezai MS, Khotael G, Kheirkhah M, Hedayat T, Geramishoar M, Mahjoub F. Cryptococcosis and deficiency of interleukin12r. Vol. 27, The Pediatric infectious disease journal. United States; 2008. p. 673.","DOI":"10.1097\/INF.0b013e318179263a"},{"issue":"2","key":"1341_CR42","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41590-021-01117-7","volume":"23","author":"A Amorim","year":"2022","unstructured":"Amorim A, De Feo D, Friebel E, Ingelfinger F, Anderfuhren CD, Krishnarajah S, et al. IFN\u03b3 and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation. Nat Immunol. 2022;23(2):217\u201328.","journal-title":"Nat Immunol"},{"key":"1341_CR43","doi-asserted-by":"publisher","first-page":"101511","DOI":"10.1016\/j.smim.2021.101511","volume":"54","author":"V Chitu","year":"2021","unstructured":"Chitu V, Biundo F, Stanley ER. Colony stimulating factors in the nervous system. Semin Immunol. 2021;54:101511.","journal-title":"Semin Immunol"},{"key":"1341_CR44","doi-asserted-by":"publisher","first-page":"742065","DOI":"10.3389\/fnins.2021.742065","volume":"15","author":"L Muzio","year":"2021","unstructured":"Muzio L, Viotti A, Martino G. Microglia in neuroinflammation and neurodegeneration: from understanding to therapy. Front Neurosci. 2021;15:742065.","journal-title":"Front Neurosci"},{"issue":"7","key":"1341_CR45","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1164\/rccm.200708-1271OC","volume":"177","author":"Y Inoue","year":"2008","unstructured":"Inoue Y, Trapnell BC, Tazawa R, Arai T, Takada T, Hizawa N, et al. Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. Am J Respir Crit Care Med. 2008;177(7):752\u201362.","journal-title":"Am J Respir Crit Care Med"},{"key":"1341_CR46","doi-asserted-by":"crossref","unstructured":"Trapnell BC, Nakata K, Bonella F, Campo I, Griese M, Hamilton J, et al. Pulmonary alveolar proteinosis. Nat Rev Dis Prim. 2019;5(1).","DOI":"10.1038\/s41572-019-0066-3"},{"issue":"11","key":"1341_CR47","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1182\/blood-2008-05-155689","volume":"113","author":"K Uchida","year":"2009","unstructured":"Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, et al. Granulocyte\/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood. 2009;113(11):2547\u201356.","journal-title":"Blood"},{"issue":"3","key":"1341_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0213179","volume":"14","author":"K Anderson","year":"2019","unstructured":"Anderson K, Carey B, Martin A, Roark C, Chalk C, Nowell-Bostic M, et al. Pulmonary alveolar proteinosis: an autoimmune disease lacking an HLA association. PLoS\u00a0One. 2019;14(3):1\u201312.","journal-title":"PLoS ONE"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01341-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-022-01341-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-022-01341-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T22:43:17Z","timestamp":1669416197000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-022-01341-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,10]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["1341"],"URL":"https:\/\/doi.org\/10.1007\/s10875-022-01341-2","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,10]]},"assertion":[{"value":"23 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted with approval from the Institutional Review Board of Chang Gung Memorial Hospital (IRB number: 103-1998C, 103-0453B, 104-9910B, 201601086B0, and\u00a0202100789B0).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All patients provided written informed consent approved by the Institutional Review Board of Chang Gung Memorial Hospital. Blood samples were obtained from patients with written informed consent, in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}