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The C19.CHILD Hamburg (COVID-19 Child Health Investigation of Latent Disease) Study is a prospective cohort study designed to identify and follow up children and their household contacts infected in the early 2020 first wave of SARS-CoV-2. We screened 6113 children\u2009&lt;\u200918\u00a0years by nasopharyngeal swab-PCR in a low-incidence setting after general lockdown, from May 11 to June 30, 2020. A total of 4657 participants underwent antibody testing. Positive tests were followed up by repeated PCR and serological testing of all household contacts over 6\u00a0months. In total, the study identified 67 seropositive children (1.44%); the median time after infection at first presentation was 83\u00a0days post-symptom onset (PSO). Follow-up of household contacts showed less than 100% seroprevalence in most families, with higher seroprevalence in families with adult index cases compared to pediatric index cases (OR 1.79,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.047). Most importantly, children showed sustained seroconversion up to 9\u00a0months PSO, and serum antibody concentrations persistently surpassed adult levels (ratio serum IgG spike children vs. adults 90\u00a0days PSO 1.75,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001; 180\u00a0days 1.38,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01; 270\u00a0days 1.54,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001). In a low-incidence setting, SARS-CoV-2 infection and humoral immune response present distinct patterns in children including higher antibody levels, and lower seroprevalence in families with pediatric index cases. Children show long-term SARS-CoV-2 antibody responses. These findings are relevant to novel variants with increased disease burden in children, as well as for the planning of age-appropriate vaccination strategies.\n                  <\/jats:p>","DOI":"10.1007\/s10875-022-01355-w","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T01:02:25Z","timestamp":1663549345000},"page":"46-56","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long-Term Antibody Response to SARS-CoV-2 in Children"],"prefix":"10.1007","volume":"43","author":[{"given":"Gabor A.","family":"Dunay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madalena","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Woidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta 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