{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:18:25Z","timestamp":1777670305849,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008386","name":"Marmara \u00dcniversitesi","doi-asserted-by":"publisher","award":["ADT-2022-10661"],"award-info":[{"award-number":["ADT-2022-10661"]}],"id":[{"id":"10.13039\/501100008386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["Lise Meitner fellowship"],"award-info":[{"award-number":["Lise Meitner fellowship"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008386","name":"Marmara University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Deficiency of stromal interaction molecule 1 (STIM1) results in combined immunodeficiency accompanied by extra-immunological findings like enamel defects and myopathy. We here studied a patient with a STIM1 loss-of-function mutation who presented with severe lymphoproliferation. We sought to explore the efficacy of the mTOR inhibitor rapamycin in controlling disease manifestations and reversing aberrant T-cell subsets and functions, which has never been used previously in this disorder.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Clinical findings of the patient were collected over time. We performed immunological evaluations before and after initiation of rapamycin treatment, including detailed lymphocyte subset analyses, alterations in frequencies of circulating T follicular helper (cT<jats:sub>FH<\/jats:sub>) and regulatory T (Treg) cells and their subtypes as well as T cell activation and proliferation capacities.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A novel homozygous exon 2 deletion in <jats:italic>STIM1<\/jats:italic> was detected in a 3-year-old girl with severe lymphoproliferation, recurrent infections, myopathy, iris hypoplasia, and enamel hypoplasia. Lymphoproliferation was associated with severe T-cell infiltrates. The deletion resulted in a complete loss of protein expression, associated with a lack of store-operated calcium entry response, defective T-cell activation, proliferation, and cytokine production. Interestingly, patient blood contained fewer cT<jats:sub>FH<\/jats:sub> and increased circulating follicular regulatory (cT<jats:sub>FR<\/jats:sub>) cells. Abnormal skewing towards T<jats:sub>H<\/jats:sub>2-like responses in certain T-cell subpopulations like cT<jats:sub>FH<\/jats:sub>, non-cT<jats:sub>FH<\/jats:sub> memory T-helper, and Treg cells was associated with increased eosinophil numbers and serum IgE levels. Treatment with rapamycin controlled lymphoproliferation, improved T-cell activation and proliferation capacities, reversed T-cell responses, and repressed high IgE levels and eosinophilia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study enhances our understanding of STIM1 deficiency by uncovering additional abnormal T-cell responses, and reveals for the first time the potential therapeutic utility of rapamycin for this disorder.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10875-024-01682-0","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T06:01:58Z","timestamp":1712296918000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rapamycin Controls Lymphoproliferation and Reverses T-Cell Responses in a Patient with a Novel STIM1 Loss-of-Function Deletion"],"prefix":"10.1007","volume":"44","author":[{"given":"Ibrahim Serhat","family":"Karakus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Cihangir","family":"Catak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Frohne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feyza","family":"Bayram Catak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melek","family":"Yorgun Altunbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Royala","family":"Babayeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi Kostel","family":"Bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi Bilgic","family":"Eltan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezgi","family":"Yalcin Gungoren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fehim","family":"Esen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itir Ebru","family":"Zemheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Karakoc-Aydiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suar","family":"Caki-Kilic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Kraakman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaan","family":"Boztug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-9422","authenticated-orcid":false,"given":"Safa","family":"Baris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"issue":"4","key":"1682_CR1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/86318","volume":"2","author":"S Feske","year":"2001","unstructured":"Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Gene regulation mediated by calcium signals in T lymphocytes. Nat Immunol. 2001;2(4):316\u201324.","journal-title":"Nat Immunol"},{"issue":"17","key":"1682_CR2","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1113\/jphysiol.2012.233221","volume":"590","author":"PJ Shaw","year":"2012","unstructured":"Shaw PJ, Feske S. Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity. J Physiol. 2012;590(17):4157\u201367.","journal-title":"J Physiol"},{"key":"1682_CR3","doi-asserted-by":"publisher","first-page":"604941","DOI":"10.3389\/fphys.2020.604941","volume":"11","author":"R Silva-Rojas","year":"2020","unstructured":"Silva-Rojas R, Laporte J, B\u00f6hm J. STIM1\/ORAI1 loss-of-function and gain-of-function mutations inversely impact on SOCE and calcium homeostasis and cause multi-systemic mirror diseases. Front Physiol. 2020;11:604941.","journal-title":"Front Physiol"},{"issue":"10","key":"1682_CR4","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.it.2020.06.012","volume":"41","author":"M Vaeth","year":"2020","unstructured":"Vaeth M, Kahlfuss S, Feske S. CRAC channels and calcium signaling in T cell-mediated immunity. Trends Immunol. 2020;41(10):878\u2013901.","journal-title":"Trends Immunol"},{"issue":"19","key":"1682_CR5","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1056\/NEJMoa0900082","volume":"360","author":"C Picard","year":"2009","unstructured":"Picard C, McCarl C-A, Papolos A, Khalil S, L\u00fcthy K, Hivroz C, et al. STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N Engl J Med. 2009;360(19):1971\u201380.","journal-title":"N Engl J Med"},{"issue":"7090","key":"1682_CR6","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature04702","volume":"441","author":"S Feske","year":"2006","unstructured":"Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006;441(7090):179\u201385.","journal-title":"Nature"},{"key":"1682_CR7","doi-asserted-by":"crossref","unstructured":"Bohm J, Chevessier F, Maues De Paula A, Koch C, Attarian S, Feger C, et al. Constitutive activation of the calcium sensor STIM1 causes tubular-aggregate myopathy. Am J Hum Genet. 2013;92(2):271\u20138.","DOI":"10.1016\/j.ajhg.2012.12.007"},{"issue":"5","key":"1682_CR8","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1399-0004.1985.tb02209.x","volume":"28","author":"H Stormorken","year":"1985","unstructured":"Stormorken H, Sjaastad O, Langslet A, Sulg I, Egge K, Diderichsen J. A new syndrome: thrombocytopathia, muscle fatigue, asplenia, miosis, migraine, dyslexia and ichthyosis. Clin Genet. 1985;28(5):367\u201374.","journal-title":"Clin Genet"},{"issue":"1","key":"1682_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/nyas.12938","volume":"1356","author":"RS Lacruz","year":"2015","unstructured":"Lacruz RS, Feske S. Diseases caused by mutations in ORAI1 and STIM1. Ann N Y Acad Sci. 2015;1356(1):45\u201379.","journal-title":"Ann N Y Acad Sci"},{"key":"1682_CR10","doi-asserted-by":"crossref","unstructured":"Baris S, Abolhassani H, Massaad MJ, Al-Nesf M, Chavoshzadeh Z, Keles S, et al. The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity. J Allergy Clin Immunol Pract. 2023;11(1):158\u201380 e11.","DOI":"10.1016\/j.jaip.2022.10.003"},{"issue":"11","key":"1682_CR11","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1084\/jem.20101597","volume":"207","author":"M Byun","year":"2010","unstructured":"Byun M, Abhyankar A, Lelarge V, Plancoulaine S, Palanduz A, Telhan L, et al. Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. J Exp Med. 2010;207(11):2307\u201312.","journal-title":"J Exp Med"},{"issue":"3","key":"1682_CR12","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.4049\/jimmunol.1102507","volume":"188","author":"S Fuchs","year":"2012","unstructured":"Fuchs S, Rensing-Ehl A, Speckmann C, Bengsch B, Schmitt-Graeff A, Bondzio I, et al. Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency. J Immunol. 2012;188(3):1523\u201333.","journal-title":"J Immunol"},{"key":"1682_CR13","doi-asserted-by":"crossref","unstructured":"Wang S, Choi M, Richardson A, Reid B, Seymen F, Yildirim M, et al. STIM1 and SLC24A4 are critical for enamel maturation. J Dental Rese. 2014;93(7_suppl):94S-100S.","DOI":"10.1177\/0022034514527971"},{"key":"1682_CR14","doi-asserted-by":"crossref","unstructured":"Schaballie H, Rodriguez R, Martin E, Moens L, Frans G, Lenoir C, et al. A novel hypomorphic mutation in STIM1 results in a late-onset immunodeficiency. J Allergy Clin Immunol. 2015;136(3):816\u20139 e4.","DOI":"10.1016\/j.jaci.2015.03.009"},{"key":"1682_CR15","doi-asserted-by":"crossref","unstructured":"Parry DA, Holmes TD, Gamper N, El-Sayed W, Hettiarachchi NT, Ahmed M, et al. A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency. J Allergy Clin Immunol. 2016;137(3):955\u20137. e8.","DOI":"10.1016\/j.jaci.2015.08.051"},{"key":"1682_CR16","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10875-019-00618-3","volume":"39","author":"L Rice","year":"2019","unstructured":"Rice L, Stockdale C, Berry I, O\u2019Riordan S, Pysden K, Anwar R, et al. A report of novel STIM1 deficiency and 6-year follow-up of two previous cases associated with mild immunological phenotype. J Clin Immunol. 2019;39:249\u201356.","journal-title":"J Clin Immunol"},{"issue":"1","key":"1682_CR17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/cge.13959","volume":"100","author":"A Salvi","year":"2021","unstructured":"Salvi A, Skrypnyk C, Da Silva N, Urtizberea JA, Bakhiet M, Robert C, et al. A novel bi-allelic loss-of-function mutation in STIM1 expands the phenotype of STIM1-related diseases. Clin Genet. 2021;100(1):84\u20139.","journal-title":"Clin Genet"},{"issue":"8","key":"1682_CR18","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911592","volume":"12","author":"S Kahlfuss","year":"2020","unstructured":"Kahlfuss S, Kaufmann U, Concepcion AR, Noyer L, Raphael D, Vaeth M, et al. STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells. EMBO Mol Med. 2020;12(8): e11592.","journal-title":"EMBO Mol Med"},{"issue":"2","key":"1682_CR19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.5582\/irdr.2020.01020","volume":"9","author":"D Derakhshan","year":"2020","unstructured":"Derakhshan D, Taherifard E, Taherifard E, Sajedianfard S, Derakhshan A. A novel frame shift mutation in STIM1 gene causing primary immunodeficiency. Intractable Rare Dis Res. 2020;9(2):109\u201312.","journal-title":"Intractable Rare Dis Res"},{"key":"1682_CR20","doi-asserted-by":"crossref","unstructured":"Kiykim A, Ogulur I, Dursun E, Charbonnier LM, Nain E, Cekic S, et al. Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency. J Allergy Clin Immunol Pract. 2019;7(8):2790\u2013800 e15.","DOI":"10.1016\/j.jaip.2019.06.011"},{"issue":"3","key":"1682_CR21","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1111\/all.15010","volume":"77","author":"B Kolukisa","year":"2022","unstructured":"Kolukisa B, Baser D, Akcam B, Danielson J, BilgicEltan S, Haliloglu Y, et al. Evolution and long-term outcomes of combined immunodeficiency due to CARMIL2 deficiency. Allergy. 2022;77(3):1004\u201319.","journal-title":"Allergy"},{"key":"1682_CR22","doi-asserted-by":"crossref","unstructured":"Baris S, Benamar M, Chen Q, Catak MC, Martinez-Blanco M, Wang M, et al. Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6. J Allergy Clin Immunol. 2023;152(1):182\u201394 e7.","DOI":"10.1016\/j.jaci.2023.01.023"},{"issue":"10","key":"1682_CR23","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1111\/all.15331","volume":"77","author":"MC Catak","year":"2022","unstructured":"Catak MC, Akcam B, BilgicEltan S, Babayeva R, Karakus IS, Akgun G, et al. Comparing the levels of CTLA-4-dependent biological defects in patients with LRBA deficiency and CTLA-4 insufficiency. Allergy. 2022;77(10):3108\u201323.","journal-title":"Allergy"},{"issue":"4","key":"1682_CR24","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s10875-020-00943-y","volume":"41","author":"B Kayaoglu","year":"2021","unstructured":"Kayaoglu B, Kasap N, Yilmaz NS, Charbonnier LM, Geckin B, Akcay A, et al. Stepwise reversal of immune dysregulation due to STAT1 gain-of-function mutation following ruxolitinib bridge therapy and transplantation. J Clin Immunol. 2021;41(4):769\u201379.","journal-title":"J Clin Immunol"},{"issue":"3","key":"1682_CR25","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1007\/s10875-021-01191-4","volume":"42","author":"AP Sefer","year":"2022","unstructured":"Sefer AP, Abolhassani H, Ober F, Kayaoglu B, BilgicEltan S, Kara A, et al. Expanding the clinical and immunological phenotypes and natural history of MALT1 deficiency. J Clin Immunol. 2022;42(3):634\u201352.","journal-title":"J Clin Immunol"},{"issue":"21","key":"1682_CR26","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1093\/bioinformatics\/bts526","volume":"28","author":"V Plagnol","year":"2012","unstructured":"Plagnol V, Curtis J, Epstein M, Mok KY, Stebbings E, Grigoriadou S, et al. A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics. 2012;28(21):2747\u201354.","journal-title":"Bioinformatics"},{"issue":"4","key":"1682_CR27","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/ni1574","volume":"9","author":"M Oh-Hora","year":"2008","unstructured":"Oh-Hora M, Yamashita M, Hogan PG, Sharma S, Lamperti E, Chung W, et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol. 2008;9(4):432\u201343.","journal-title":"Nat Immunol"},{"issue":"9","key":"1682_CR28","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.4049\/jimmunol.1700610","volume":"202","author":"MLX Oh-Hora","year":"2019","unstructured":"Oh-Hora MLX, Shiokawa M, Takayanagi H, Yamasaki S. Stromal interaction molecule deficiency in T cells promotes spontaneous follicular helper T cell development and causes type 2 immune disorders. J Immunol. 2019;202(9):2616\u201327.","journal-title":"J Immunol"},{"issue":"6","key":"1682_CR29","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.immuni.2016.04.013","volume":"44","author":"M Vaeth","year":"2016","unstructured":"Vaeth M, Eckstein M, Shaw PJ, Kozhaya L, Yang J, Berberich-Siebelt F, et al. Store-operated Ca(2+) entry in follicular T cells controls humoral immune responses and autoimmunity. Immunity. 2016;44(6):1350\u201364.","journal-title":"Immunity"},{"issue":"11","key":"1682_CR30","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1016\/j.biocel.2013.07.014","volume":"45","author":"E Samakai","year":"2013","unstructured":"Samakai E, Hooper R, Soboloff J. The critical role of STIM1-dependent Ca2+ signalling during T-cell development and activation. Int J Biochem Cell Biol. 2013;45(11):2491\u20135.","journal-title":"Int J Biochem Cell Biol"},{"key":"1682_CR31","doi-asserted-by":"crossref","unstructured":"Vaeth M, Maus M, Klein-Hessling S, Freinkman E, Yang J, Eckstein M, et al. Store-operated Ca(2+) Entry controls clonal expansion of T cells through metabolic reprogramming. Immunity. 2017;47(4):664\u201379 e6.","DOI":"10.1016\/j.immuni.2017.09.003"},{"issue":"9","key":"1682_CR32","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41590-019-0442-x","volume":"20","author":"LM Charbonnier","year":"2019","unstructured":"Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of Foxp3. Nat Immunol. 2019;20(9):1208\u201319.","journal-title":"Nat Immunol"},{"issue":"12","key":"1682_CR33","doi-asserted-by":"publisher","first-page":"8338","DOI":"10.4049\/jimmunol.177.12.8338","volume":"177","author":"M Battaglia","year":"2006","unstructured":"Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol. 2006;177(12):8338\u201347.","journal-title":"J Immunol"},{"issue":"1","key":"1682_CR34","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/s41467-019-08959-8","volume":"10","author":"M Vaeth","year":"2019","unstructured":"Vaeth M, Wang YH, Eckstein M, Yang J, Silverman GJ, Lacruz RS, et al. Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels. Nat Commun. 2019;10(1):1183.","journal-title":"Nat Commun"},{"issue":"6","key":"1682_CR35","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1172\/JCI80273","volume":"125","author":"L Desvignes","year":"2015","unstructured":"Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, et al. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest. 2015;125(6):2347\u201362.","journal-title":"J Clin Invest"},{"issue":"8","key":"1682_CR36","doi-asserted-by":"publisher","first-page":"4416","DOI":"10.1074\/jbc.273.8.4416","volume":"273","author":"CJ Holtz-Heppelmann","year":"1998","unstructured":"Holtz-Heppelmann CJ, Algeciras A, Badley AD, Paya CV. Transcriptional regulation of the human FasL promoter-enhancer region. J Biol Chem. 1998;273(8):4416\u201323.","journal-title":"J Biol Chem"},{"issue":"5","key":"1682_CR37","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.4049\/jimmunol.166.5.3201","volume":"166","author":"JM Slavik","year":"2001","unstructured":"Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes. J Immunol. 2001;166(5):3201\u20139.","journal-title":"J Immunol"},{"issue":"2","key":"1682_CR38","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1074\/jbc.M209733200","volume":"279","author":"JM Slavik","year":"2004","unstructured":"Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. J Biol Chem. 2004;279(2):910\u20139.","journal-title":"J Biol Chem"},{"issue":"1","key":"1682_CR39","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.0105-2896.2010.00898.x","volume":"235","author":"K Araki","year":"2010","unstructured":"Araki K, Youngblood B, Ahmed R. The role of mTOR in memory CD8 T-cell differentiation. Immunol Rev. 2010;235(1):234\u201343.","journal-title":"Immunol Rev"},{"issue":"3","key":"1682_CR40","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.smim.2007.02.008","volume":"19","author":"A Mondino","year":"2007","unstructured":"Mondino A, Mueller DL. mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol. 2007;19(3):162\u201372.","journal-title":"Semin Immunol"},{"issue":"1","key":"1682_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","volume":"111","author":"C Wehr","year":"2008","unstructured":"Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood. 2008;111(1):77\u201385.","journal-title":"Blood"},{"key":"1682_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102300","volume":"82","author":"B Keller","year":"2023","unstructured":"Keller B, Warnatz K. T-bet(high)CD21(low) B cells: the need to unify our understanding of a distinct B cell population in health and disease. Curr Opin Immunol. 2023;82: 102300.","journal-title":"Curr Opin Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-024-01682-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-024-01682-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-024-01682-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:11:27Z","timestamp":1719223887000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-024-01682-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["1682"],"URL":"https:\/\/doi.org\/10.1007\/s10875-024-01682-0","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"assertion":[{"value":"6 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Marmara University, School of Medicine (09.2018.624).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent for participation was obtained from all individuals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Informed publication consent was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Dr. Baris obtained a grant from the Marmara University Scientific Research Project Coordination Unit. The other co-authors have no conflict of interest to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Disclosure"}}],"article-number":"94"}}