{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:36:53Z","timestamp":1778254613856,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Chongqing medical scientific research project","award":["NO.2024GGXM004"],"award-info":[{"award-number":["NO.2024GGXM004"]}]},{"name":"Youth Innovation in Future Medicine, Chongqing Medical University","award":["W0132"],"award-info":[{"award-number":["W0132"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["2023NSCQ-MSX0212"],"award-info":[{"award-number":["2023NSCQ-MSX0212"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10875-024-01753-2","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:03:42Z","timestamp":1718780622000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Immune Reconstitution in a Patient with a TYK2 Deficiency after Allogeneic Stem Cell Transplantation from Unrelated Donors"],"prefix":"10.1007","volume":"44","author":[{"given":"Yelei","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"issue":"4","key":"1753_CR1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/ni.3691","volume":"18","author":"AV Villarino","year":"2017","unstructured":"Villarino AV, Kanno Y, O\u2019Shea JJ. Mechanisms and consequences of Jak\u2013STAT signaling in the immune system. Nat Immunol. 2017;18(4):374\u201384. https:\/\/doi.org\/10.1038\/ni.3691.","journal-title":"Nat Immunol"},{"issue":"21","key":"1753_CR2","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","volume":"185","author":"RL Philips","year":"2022","unstructured":"Philips RL, Wang Y, Cheon H, et al. The JAK-STAT pathway at 30: much learned, much more to do. Cell. 2022;185(21):3857\u201376. https:\/\/doi.org\/10.1016\/j.cell.2022.09.023.","journal-title":"Cell"},{"issue":"7","key":"1753_CR3","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s10875-022-01289-3","volume":"42","author":"SG Tangye","year":"2022","unstructured":"Tangye SG, Al-Herz W, Bousfiha A, et al. Human inborn errors of immunity: 2022 update on the classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2022;42(7):1473\u2013507. https:\/\/doi.org\/10.1007\/s10875-022-01289-3.","journal-title":"J Clin Immunol"},{"issue":"2","key":"1753_CR4","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00431-021-04223-8","volume":"181","author":"Q Zhao","year":"2021","unstructured":"Zhao Q, Dai R, Li Y, et al. Trends in TREC values according to age and gender in Chinese children and their clinical applications. Eur J Pediatr. 2021;181(2):529\u201338. https:\/\/doi.org\/10.1007\/s00431-021-04223-8.","journal-title":"Eur J Pediatr"},{"key":"1753_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/978-1-59745-395-0_12","volume":"380","author":"ML Dion","year":"2007","unstructured":"Dion ML, S\u00e9kaly RP, Cheynier R. Estimating thymic function through quantification of T-Cell receptor excision circles. Methods Mol Bio. 2007;380:197\u2013213. https:\/\/doi.org\/10.1007\/978-1-59745-395-0_12.","journal-title":"Methods Mol Bio"},{"key":"1753_CR6","doi-asserted-by":"publisher","unstructured":"Sottini A, Serana F, Bertoli D et al. Simultaneous quantification of T-cell receptor excision circles (TRECs) and K-deleting recombination excision circles (KRECs) by real-time PCR. J Vis Exp. 2014(94). https:\/\/doi.org\/10.3791\/52184.","DOI":"10.3791\/52184"},{"issue":"1","key":"1753_CR7","doi-asserted-by":"publisher","first-page":"e13671","DOI":"10.1111\/pai.13671","volume":"33","author":"G Lv","year":"2022","unstructured":"Lv G, Sun G, Wu P, et al. Novel mutations of TYK2 leading to divergent clinical phenotypes. Pediatr Allergy Immunol. 2022;33(1):e13671. https:\/\/doi.org\/10.1111\/pai.13671.","journal-title":"Pediatr Allergy Immunol"},{"issue":"3","key":"1753_CR8","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.jaci.2018.04.022","volume":"142","author":"Y Ding","year":"2018","unstructured":"Ding Y, Zhou L, Xia Y, et al. Reference values for peripheral blood lymphocyte subsets of healthy children in China. J Allergy Clin Immunol. 2018;142(3):970\u2013e38. https:\/\/doi.org\/10.1016\/j.jaci.2018.04.022.","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"1753_CR9","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","volume":"11","author":"AH Filipovich","year":"2005","unstructured":"Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. diagnosis and staging working group report. Biol Blood Marrow Transpl. 2005;11(12):945\u201356. https:\/\/doi.org\/10.1016\/j.bbmt.2005.09.004.","journal-title":"Biol Blood Marrow Transpl"},{"key":"1753_CR10","doi-asserted-by":"publisher","unstructured":"Ogishi M, Arias AA, Yang R, et al. Impaired IL-23-dependent induction of IFN-\u03b3 underlies mycobacterial disease in patients with inherited TYK2 deficiency. J Exp Med. 2022;219(10). https:\/\/doi.org\/10.1084\/jem.20220094.","DOI":"10.1084\/jem.20220094"},{"issue":"10","key":"1753_CR11","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1084\/jem.20140280","volume":"212","author":"AY Kreins","year":"2015","unstructured":"Kreins AY, Ciancanelli MJ, Okada S, et al. Human TYK2 deficiency: mycobacterial and viral infections without hyper-IgE syndrome. J Exp Med. 2015;212(10):1641\u201362. https:\/\/doi.org\/10.1084\/jem.20140280.","journal-title":"J Exp Med"},{"issue":"1","key":"1753_CR12","doi-asserted-by":"publisher","first-page":"6956","DOI":"10.1038\/s41598-018-25260-8","volume":"8","author":"M Nemoto","year":"2018","unstructured":"Nemoto M, Hattori H, Maeda N, et al. Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia. Sci Rep. 2018;8(1):6956. https:\/\/doi.org\/10.1038\/s41598-018-25260-8.","journal-title":"Sci Rep"},{"issue":"8","key":"1753_CR13","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1007\/s10875-023-01580-x","volume":"43","author":"L Roussel","year":"2023","unstructured":"Roussel L, Pham-Huy A, Yu AC, et al. A novel homozygous mutation causing Complete TYK2 Deficiency, with severe respiratory viral infections, EBV-Driven Lymphoma, and Jamestown Canyon viral encephalitis. J Clin Immunol. 2023;43(8):2011\u201321. https:\/\/doi.org\/10.1007\/s10875-023-01580-x.","journal-title":"J Clin Immunol"},{"issue":"5","key":"1753_CR14","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.immuni.2006.09.009","volume":"25","author":"Y Minegishi","year":"2006","unstructured":"Minegishi Y, Saito M, Morio T, et al. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006;25(5):745\u201355. https:\/\/doi.org\/10.1016\/j.immuni.2006.09.009.","journal-title":"Immunity"},{"key":"1753_CR15","doi-asserted-by":"publisher","unstructured":"Boisson-Dupuis S, Ramirez-Alejo N, Li Z, et al. Tuberculosis and impaired IL-23-dependent IFN-\u03b3 immunity in humans homozygous for a common TYK2 missense variant. Sci Immunol. 2018;3(30). https:\/\/doi.org\/10.1126\/sciimmunol.aau8714.","DOI":"10.1126\/sciimmunol.aau8714"},{"issue":"8","key":"1753_CR16","doi-asserted-by":"publisher","first-page":"e20220131","DOI":"10.1084\/jem.20220131","volume":"219","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Matuozzo D, Le Pen J, et al. Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia. J Exp Med. 2022;219(8):e20220131. https:\/\/doi.org\/10.1084\/jem.20220131.","journal-title":"J Exp Med"},{"key":"1753_CR17","doi-asserted-by":"publisher","first-page":"4347","DOI":"10.2147\/idr.S279438","volume":"13","author":"W Guo","year":"2020","unstructured":"Guo W, Feng X, Yang M, et al. Mycobacterium Intracellulare Infection Associated with TYK2 Deficiency: a Case Report and Review of the literature. Infect Drug Resist. 2020;13:4347\u201353. https:\/\/doi.org\/10.2147\/idr.S279438.","journal-title":"Infect Drug Resist"},{"key":"1753_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3389\/fped.2020.00253","volume":"8","author":"P Wu","year":"2020","unstructured":"Wu P, Chen S, Wu B, et al. A TYK2 gene mutation c.2395G\u2009>\u2009A leads to TYK2 Deficiency: a Case Report and Literature Review. Front Pediatr. 2020;8:253. https:\/\/doi.org\/10.3389\/fped.2020.00253.","journal-title":"Front Pediatr"},{"issue":"1","key":"1753_CR19","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s10875-019-00713-5","volume":"40","author":"S Sarrafzadeh","year":"2020","unstructured":"Sarrafzadeh S, Mahloojirad M, Casanova J, et al. A new patient with inherited TYK2 Deficiency. J Clin Immunol. 2020;40(1):232\u20135. https:\/\/doi.org\/10.1007\/s10875-019-00713-5.","journal-title":"J Clin Immunol"},{"issue":"6","key":"1753_CR20","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.jpeds.2012.01.056","volume":"160","author":"SS Kilic","year":"2012","unstructured":"Kilic SS, Hacimustafaoglu M, Boisson-Dupuis S, et al. A patient with tyrosine kinase 2 Deficiency without Hyper-IgE Syndrome. J Pediatr. 2012;160(6):1055\u20137. https:\/\/doi.org\/10.1016\/j.jpeds.2012.01.056.","journal-title":"J Pediatr"},{"issue":"11","key":"1753_CR21","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1002\/eji.201646519","volume":"46","author":"S Fuchs","year":"2016","unstructured":"Fuchs S, Kaiser-Labusch P, Bank J, et al. Tyrosine kinase 2 is not limiting human antiviral type III interferon responses. Eur J Immunol. 2016;46(11):2639\u201349. https:\/\/doi.org\/10.1002\/eji.201646519.","journal-title":"Eur J Immunol"},{"issue":"1","key":"1753_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4331\/wjbc.v13.i1.1","volume":"13","author":"R Muromoto","year":"2022","unstructured":"Muromoto R, Oritani K, Matsuda T. Current understanding of the role of tyrosine kinase 2 signaling in immune responses. World J Biol Chem. 2022;13(1):1\u201314. https:\/\/doi.org\/10.4331\/wjbc.v13.i1.1.","journal-title":"World J Biol Chem"},{"issue":"6","key":"1753_CR23","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s004180000142","volume":"113","author":"H Nishio","year":"2000","unstructured":"Nishio H, Matsui K, Tsuji H, et al. Expression of the janus kinases-signal transducers and activators of transcription pathway in Hassall\u2019s corpuscles of the human thymus. Histochem Cell Biol. 2000;113(6):427\u201331. https:\/\/doi.org\/10.1007\/s004180000142.","journal-title":"Histochem Cell Biol"},{"key":"1753_CR24","doi-asserted-by":"publisher","first-page":"1103080","DOI":"10.3389\/fimmu.2023.1103080","volume":"14","author":"G Dell\u2019Orso","year":"2023","unstructured":"Dell\u2019Orso G, Bagnasco F, Giardino S, et al. Hematopoietic stem cell transplantation for inborn errors of immunity: 30-year single-center experience. Front Immunol. 2023;14:1103080. https:\/\/doi.org\/10.3389\/fimmu.2023.1103080.","journal-title":"Front Immunol"},{"key":"1753_CR25","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3389\/fped.2019.00295","volume":"7","author":"R Castagnoli","year":"2019","unstructured":"Castagnoli R, Delmonte O, Calzoni E, et al. Hematopoietic stem cell transplantation in primary Immunodeficiency diseases: current status and future perspectives. Front Pediatr. 2019;7:295. https:\/\/doi.org\/10.3389\/fped.2019.00295.","journal-title":"Front Pediatr"},{"issue":"4","key":"1753_CR26","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/1744666x.2018.1459189","volume":"14","author":"A Laberko","year":"2018","unstructured":"Laberko A, Gennery A. Clinical considerations in the hematopoietic stem cell transplant management of primary immunodeficiencies. Expert Rev Clin Immunol. 2018;14(4):297\u2013306. https:\/\/doi.org\/10.1080\/1744666x.2018.1459189.","journal-title":"Expert Rev Clin Immunol"},{"key":"1753_CR27","doi-asserted-by":"publisher","unstructured":"Chang TY, Jaing TH, Lee WI, et al. Single-institution experience of unrelated cord blood transplantation for primary immunodeficiency. J Pediatr Hematol Oncol. 2015;37(3). https:\/\/doi.org\/10.1097\/MPH.0000000000000232.","DOI":"10.1097\/MPH.0000000000000232"},{"issue":"9","key":"1753_CR28","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1038\/s41409-021-01378-8","volume":"56","author":"A Lankester","year":"2021","unstructured":"Lankester A, Albert M, Booth C, et al. EBMT\/ESID inborn errors working party guidelines for hematopoietic stem cell transplantation for inborn errors of immunity. Bone Marrow Transpl. 2021;56(9):2052\u201362. https:\/\/doi.org\/10.1038\/s41409-021-01378-8.","journal-title":"Bone Marrow Transpl"},{"issue":"1","key":"1753_CR29","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s10875-021-01145-w","volume":"42","author":"A Kreins","year":"2022","unstructured":"Kreins A, Velasco H, Cheong K, et al. Long-term Immune Recovery after hematopoietic stem cell transplantation for ADA Deficiency: a single-center experience. J Clin Immunol. 2022;42(1):94\u2013107. https:\/\/doi.org\/10.1007\/s10875-021-01145-w.","journal-title":"J Clin Immunol"},{"issue":"1","key":"1753_CR30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10875-021-01155-8","volume":"42","author":"A Laberko","year":"2022","unstructured":"Laberko A, Deordieva E, Krivan G, et al. Multicenter Experience of hematopoietic stem cell transplantation in WHIM Syndrome. J Clin Immunol. 2022;42(1):171\u201382. https:\/\/doi.org\/10.1007\/s10875-021-01155-8.","journal-title":"J Clin Immunol"}],"updated-by":[{"DOI":"10.1007\/s10875-024-01762-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000}}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-024-01753-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-024-01753-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-024-01753-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:08:57Z","timestamp":1724058537000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-024-01753-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["1753"],"URL":"https:\/\/doi.org\/10.1007\/s10875-024-01753-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s10875-024-01762-1","asserted-by":"object"}]},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,19]]},"assertion":[{"value":"24 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10875-024-01762-1","URL":"https:\/\/doi.org\/10.1007\/s10875-024-01762-1","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"152"}}