{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:37:29Z","timestamp":1777307849738,"version":"3.51.4"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"This work is supported in part by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health"},{"name":"E.G.S. was supported by NIH grant","award":["1K08AI182483"],"award-info":[{"award-number":["1K08AI182483"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10875-025-01923-w","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T04:32:38Z","timestamp":1760675558000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disseminated Histoplasmosis in Very Early Diagnosed De Novo STAT3-HIES"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-8487","authenticated-orcid":false,"given":"Armen","family":"Sanosyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Hazan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra F.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica G.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline C.","family":"Horner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"1923_CR1","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1007\/s10875-021-01051-1","volume":"41","author":"C Tsilifis","year":"2021","unstructured":"Tsilifis C, Freeman AF, Gennery AR. STAT3 Hyper-IgE Syndrome-an update and unanswered questions. J Clin Immunol. 2021;41:864\u201380.","journal-title":"J Clin Immunol"},{"key":"1923_CR2","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1111\/all.13969","volume":"74","author":"W van de Veen","year":"2019","unstructured":"van de Veen W, Kr\u00e4tz CE, McKenzie CI, Aui PM, Neumann J, van Noesel CJM, et al. Impaired memory B-cell development and antibody maturation with a skewing toward IgE in patients with STAT3 hyper-IgE syndrome. Allergy. 2019;74:2394\u2013405.","journal-title":"Allergy"},{"key":"1923_CR3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13223-023-00776-5","volume":"19","author":"M Carrabba","year":"2023","unstructured":"Carrabba M, Dellepiane RM, Cortesi M, Baselli LA, Soresina A, Cirillo E, et al. Long term longitudinal follow-up of an AD-HIES cohort: the impact of early diagnosis and enrollment to IPINet centers on the natural history of Job\u2019s syndrome. Allergy Asthma Clin Immunol. 2023;19:32.","journal-title":"Allergy Asthma Clin Immunol"},{"key":"1923_CR4","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/j.jaci.2015.07.003","volume":"136","author":"CD Odio","year":"2015","unstructured":"Odio CD, Milligan KL, McGowan K, Spergel AKR, Bishop R, Boris L, et al. Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome. J Allergy Clin Immunol. 2015;136:1411\u2013e14132.","journal-title":"J Allergy Clin Immunol"},{"key":"1923_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1055\/s-0039-1698429","volume":"41","author":"MM Azar","year":"2020","unstructured":"Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current concepts in the epidemiology, diagnosis, and management of histoplasmosis syndromes. Semin Respir Crit Care Med. 2020;41:13\u201330.","journal-title":"Semin Respir Crit Care Med"},{"key":"1923_CR6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1309\/X0Y2-P3GY-TWE8-DM02","volume":"113","author":"LW Lamps","year":"2000","unstructured":"Lamps LW, Molina CP, West AB, Haggitt RC, Scott MA. The pathologic spectrum of Gastrointestinal and hepatic histoplasmosis. Am J Clin Pathol. 2000;113:64\u201372.","journal-title":"Am J Clin Pathol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-025-01923-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-025-01923-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-025-01923-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:47:53Z","timestamp":1777304873000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-025-01923-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1923"],"URL":"https:\/\/doi.org\/10.1007\/s10875-025-01923-w","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"21 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"145"}}