{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:36:12Z","timestamp":1777307772836,"version":"3.51.4"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH336"],"award-info":[{"award-number":["ZR2022QH336"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371117"],"award-info":[{"award-number":["82371117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10875-025-01953-4","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T06:31:40Z","timestamp":1763188300000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["S100A4 Induces Neutrophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps via TLR4 Pathway"],"prefix":"10.1007","volume":"45","author":[{"given":"Yanyi","family":"Tu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghui","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"issue":"2","key":"1953_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/cea.14065","volume":"52","author":"Y Yao","year":"2022","unstructured":"Yao Y, Zeng M, Liu Z. Revisiting Asian chronic rhinosinusitis in the era of type 2 biologics. Clin Exp Allergy. 2022;52(2):231\u201343. https:\/\/doi.org\/10.1111\/cea.14065.","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"1953_CR2","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jaci.2016.05.041","volume":"138","author":"X Wang","year":"2016","unstructured":"Wang X, Zhang N, Bo M, et al. Diversity of T(H) cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania. J Allergy Clin Immunol. 2016;138(5):1344\u201353. https:\/\/doi.org\/10.1016\/j.jaci.2016.05.041.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1953_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.anai.2018.10.014","volume":"122","author":"PP Cao","year":"2019","unstructured":"Cao PP, Wang ZC, Schleimer RP, Liu Z. Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes. Ann Allergy Asthma Immunol. 2019;122(1):33\u201340. https:\/\/doi.org\/10.1016\/j.anai.2018.10.014.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"1953_CR4","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1111\/all.13411","volume":"73","author":"B Liao","year":"2018","unstructured":"Liao B, Liu JX, Li ZY, et al. Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes. Allergy. 2018;73(7):1459\u201369. https:\/\/doi.org\/10.1111\/all.13411.","journal-title":"Allergy"},{"issue":"5","key":"1953_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00109-007-0301-3","volume":"86","author":"M Schneider","year":"2008","unstructured":"Schneider M, Hansen JL, Sheikh SP. S100A4: a common mediator of epithelial-mesenchymal transition, fibrosis and regeneration in diseases? J Mol Med (Berl). 2008;86(5):507\u201322. https:\/\/doi.org\/10.1007\/s00109-007-0301-3.","journal-title":"J Mol Med (Berl)"},{"issue":"10","key":"1953_CR6","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.7150\/jca.73365","volume":"13","author":"H Wang","year":"2022","unstructured":"Wang H, Mao X, Ye L, Cheng H, Dai X. The role of the S100 protein family in glioma. J Cancer. 2022;13(10):3022\u201330. https:\/\/doi.org\/10.7150\/jca.73365.","journal-title":"J Cancer"},{"issue":"1","key":"1953_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/cmi.2016.34","volume":"14","author":"D Bertheloot","year":"2017","unstructured":"Bertheloot D, Latz E. HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins. Cell Mol Immunol. 2017;14(1):43\u201364. https:\/\/doi.org\/10.1038\/cmi.2016.34.","journal-title":"Cell Mol Immunol"},{"key":"1953_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5488591","volume":"2021","author":"Z Sattar","year":"2021","unstructured":"Sattar Z, Lora A, Jundi B, Railwah C, Geraghty P. The S100 protein family as players and therapeutic targets in pulmonary diseases. Pulm Med. 2021;2021:5488591. https:\/\/doi.org\/10.1155\/2021\/5488591.","journal-title":"Pulm Med"},{"key":"1953_CR9","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/978-1-4939-9030-6_22","volume":"1929","author":"N Ambartsumian","year":"2019","unstructured":"Ambartsumian N, Klingelhofer J, Grigorian M. The multifaceted S100A4 protein in cancer and inflammation. Methods Mol Biol. 2019;1929:339\u201365. https:\/\/doi.org\/10.1007\/978-1-4939-9030-6_22.","journal-title":"Methods Mol Biol"},{"issue":"4","key":"1953_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040798","volume":"10","author":"N D\u2019Ambrosi","year":"2021","unstructured":"D\u2019Ambrosi N, Milani M, Apolloni S. S100A4 in the physiology and pathology of the central and peripheral nervous system. Cells. 2021;10(4):798. https:\/\/doi.org\/10.3390\/cells10040798.","journal-title":"Cells"},{"key":"1953_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1828791","volume":"2018","author":"S Destek","year":"2018","unstructured":"Destek S, Gul VO. S100A4 may be a good prognostic marker and a therapeutic target for colon cancer. J Oncol. 2018;2018:1828791. https:\/\/doi.org\/10.1155\/2018\/1828791.","journal-title":"J Oncol"},{"issue":"38","key":"1953_CR12","doi-asserted-by":"publisher","first-page":"16002","DOI":"10.1073\/pnas.1109493108","volume":"108","author":"JT O'Connell","year":"2011","unstructured":"O\u2019Connell JT, Sugimoto H, Cooke VG, et al. VEGF-A and tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A. 2011;108(38):16002\u20137. https:\/\/doi.org\/10.1073\/pnas.1109493108.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1953_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01216","volume":"9","author":"W Zhang","year":"2018","unstructured":"Zhang W, Ohno S, Steer B, et al. S100a4 is secreted by alternatively activated alveolar macrophages and promotes activation of lung fibroblasts in pulmonary fibrosis. Front Immunol. 2018;9:1216. https:\/\/doi.org\/10.3389\/fimmu.2018.01216.","journal-title":"Front Immunol"},{"issue":"15","key":"1953_CR14","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1091\/mbc.e09-07-0609","volume":"21","author":"ZH Li","year":"2010","unstructured":"Li ZH, Dulyaninova NG, House RP, Almo SC, Bresnick AR. S100A4 regulates macrophage chemotaxis. Mol Biol Cell. 2010;21(15):2598\u2013610. https:\/\/doi.org\/10.1091\/mbc.e09-07-0609.","journal-title":"Mol Biol Cell"},{"key":"1953_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1525567","volume":"16","author":"T Wong","year":"2025","unstructured":"Wong T, Kang R, Yun K. The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease. Front Immunol. 2025;16:1525567. https:\/\/doi.org\/10.3389\/fimmu.2025.1525567.","journal-title":"Front Immunol"},{"issue":"9","key":"1953_CR16","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1128\/MCB.26.9.3625-3638.2006","volume":"26","author":"D Kiryushko","year":"2006","unstructured":"Kiryushko D, Novitskaya V, Soroka V, et al. Molecular mechanisms of Ca(2+) signaling in neurons induced by the S100A4 protein. Mol Cell Biol. 2006;26(9):3625\u201338. https:\/\/doi.org\/10.1128\/MCB.26.9.3625-3638.2006.","journal-title":"Mol Cell Biol"},{"issue":"3","key":"1953_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1161\/01.RES.0000176025.57706.1e","volume":"97","author":"A Lawrie","year":"2005","unstructured":"Lawrie A, Spiekerkoetter E, Martinez EC, et al. Interdependent serotonin transporter and receptor pathways regulate S100A4\/Mts1, a gene associated with pulmonary vascular disease. Circ Res. 2005;97(3):227\u201335. https:\/\/doi.org\/10.1161\/01.RES.0000176025.57706.1e.","journal-title":"Circ Res"},{"issue":"8","key":"1953_CR18","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1093\/rheumatology\/keu031","volume":"53","author":"LA Cerezo","year":"2014","unstructured":"Cerezo LA, Remakova M, Tomcik M, et al. The metastasis-associated protein S100A4 promotes the inflammatory response of mononuclear cells via the TLR4 signalling pathway in rheumatoid arthritis. Rheumatology (Oxford). 2014;53(8):1520\u20136. https:\/\/doi.org\/10.1093\/rheumatology\/keu031.","journal-title":"Rheumatology (Oxford)"},{"key":"1953_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00388","volume":"9","author":"Q Li","year":"2018","unstructured":"Li Q, Dai C, Xue R, et al. S100A4 protects myeloid-derived suppressor cells from intrinsic apoptosis via TLR4-ERK1\/2 signaling. Front Immunol. 2018;9:388. https:\/\/doi.org\/10.3389\/fimmu.2018.00388.","journal-title":"Front Immunol"},{"key":"1953_CR20","doi-asserted-by":"publisher","first-page":"111555","DOI":"10.1016\/j.intimp.2024.111555","volume":"128","author":"M Shihui","year":"2024","unstructured":"Shihui M, Shirong Y, Jing L, et al. S100A4 reprofiles lipid metabolism in mast cells via RAGE and PPAR-gamma signaling pathway. Int Immunopharmacol. 2024;128:111555. https:\/\/doi.org\/10.1016\/j.intimp.2024.111555.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"1953_CR21","doi-asserted-by":"publisher","first-page":"L185","DOI":"10.1152\/ajplung.00347.2019","volume":"319","author":"Y Wu","year":"2020","unstructured":"Wu Y, Zhang W, Gunst SJ. S100A4 is secreted by airway smooth muscle tissues and activates inflammatory signaling pathways via receptors for advanced glycation end products. Am J Physiol Lung Cell Mol Physiol. 2020;319(1):L185\u201395. https:\/\/doi.org\/10.1152\/ajplung.00347.2019.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"218","key":"1953_CR22","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007410","volume":"6","author":"S Bruhn","year":"2014","unstructured":"Bruhn S, Fang Y, Barrenas F, et al. A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy. Sci Transl Med. 2014;6(218):218ra4. https:\/\/doi.org\/10.1126\/scitranslmed.3007410.","journal-title":"Sci Transl Med"},{"key":"1953_CR23","doi-asserted-by":"publisher","first-page":"835888","DOI":"10.3389\/fimmu.2022.835888","volume":"13","author":"N Gong","year":"2022","unstructured":"Gong N, Shi L, Bing X, et al. S100A4\/TCF complex transcription regulation drives epithelial-mesenchymal transition in chronic sinusitis through Wnt\/GSK-3beta\/beta-catenin signaling. Front Immunol. 2022;13:835888. https:\/\/doi.org\/10.3389\/fimmu.2022.835888.","journal-title":"Front Immunol"},{"issue":"11","key":"1953_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24154","volume":"123","author":"K Ikeda","year":"2013","unstructured":"Ikeda K, Shiozawa A, Ono N, et al. Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil. Laryngoscope. 2013;123(11):E1-9. https:\/\/doi.org\/10.1002\/lary.24154.","journal-title":"Laryngoscope"},{"issue":"1","key":"1953_CR25","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4168\/aair.2023.15.1.94","volume":"15","author":"H Cha","year":"2023","unstructured":"Cha H, Lim HS, Park JA, et al. Effects of neutrophil and eosinophil extracellular trap formation on refractoriness in chronic rhinosinusitis with nasal polyps. Allergy Asthma Immunol Res. 2023;15(1):94\u2013108. https:\/\/doi.org\/10.4168\/aair.2023.15.1.94.","journal-title":"Allergy Asthma Immunol Res"},{"issue":"S29","key":"1953_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4193\/Rhin20.600","volume":"58","author":"WJ Fokkens","year":"2020","unstructured":"Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58(S29):1\u2013464. https:\/\/doi.org\/10.4193\/Rhin20.600.","journal-title":"Rhinology"},{"issue":"3","key":"1953_CR27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.jaci.2020.02.010","volume":"146","author":"CL Chen","year":"2020","unstructured":"Chen CL, Yao Y, Pan L, et al. Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes. J Allergy Clin Immunol. 2020;146(3):677\u201381. https:\/\/doi.org\/10.1016\/j.jaci.2020.02.010.","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"1953_CR28","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.jaci.2015.12.1324","volume":"137","author":"P Tomassen","year":"2016","unstructured":"Tomassen P, Vandeplas G, Van Zele T, et al. Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. J Allergy Clin Immunol. 2016;137(5):1449-1456 e4. https:\/\/doi.org\/10.1016\/j.jaci.2015.12.1324.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"1953_CR29","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1111\/all.13424","volume":"73","author":"J Liu","year":"2018","unstructured":"Liu J, Li YY, Andiappan AK, et al. Role of IL-13Ralpha2 in modulating IL-13-induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa. Allergy. 2018;73(8):1673\u201385. https:\/\/doi.org\/10.1111\/all.13424.","journal-title":"Allergy"},{"issue":"1","key":"1953_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/srep08453","volume":"5","author":"P Che","year":"2015","unstructured":"Che P, Yang Y, Han X, et al. S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase. Sci Rep. 2015;5(1):8453. https:\/\/doi.org\/10.1038\/srep08453.","journal-title":"Sci Rep"},{"issue":"3","key":"1953_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057017","volume":"8","author":"Z Wang","year":"2013","unstructured":"Wang Z, Griffin M. The role of TG2 in regulating S100A4-mediated mammary tumour cell migration. PLoS One. 2013;8(3):e57017. https:\/\/doi.org\/10.1371\/journal.pone.0057017.","journal-title":"PLoS One"},{"key":"1953_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119490","volume":"277","author":"L Zhang","year":"2021","unstructured":"Zhang L, Jiang Y, Deng S, et al. S100B\/RAGE\/Ceramide signaling pathway is involved in sepsis-associated encephalopathy. Life Sci. 2021;277:119490. https:\/\/doi.org\/10.1016\/j.lfs.2021.119490.","journal-title":"Life Sci"},{"key":"1953_CR33","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkad030","volume":"11","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Song Y, Du J, et al. S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion. Burns Trauma. 2023;11:tkad030. https:\/\/doi.org\/10.1093\/burnst\/tkad030.","journal-title":"Burns Trauma"},{"key":"1953_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02231","volume":"10","author":"J Park","year":"2019","unstructured":"Park J, Baik SH, Mook-Jung I, Irimia D, Cho H. Mimicry of central-peripheral immunity in Alzheimer\u2019s disease and discovery of neurodegenerative roles in neutrophil. Front Immunol. 2019;10:2231. https:\/\/doi.org\/10.3389\/fimmu.2019.02231.","journal-title":"Front Immunol"},{"key":"1953_CR35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cellsig.2018.11.004","volume":"54","author":"K Rajarathnam","year":"2019","unstructured":"Rajarathnam K, Schnoor M, Richardson RM, Rajagopal S. How do chemokines navigate neutrophils to the target site: dissecting the structural mechanisms and signaling pathways. Cell Signal. 2019;54:69\u201380. https:\/\/doi.org\/10.1016\/j.cellsig.2018.11.004.","journal-title":"Cell Signal"},{"issue":"3","key":"1953_CR36","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.jaci.2024.10.038","volume":"155","author":"H Urakami","year":"2025","unstructured":"Urakami H, Yoshikawa S, Nagao K, et al. Stress-experienced monocytes\/macrophages lose anti-inflammatory function via \u03b22-adrenergic receptor in skin allergic inflammation. J Allergy Clin Immunol. 2025;155(3):865\u201379. https:\/\/doi.org\/10.1016\/j.jaci.2024.10.038.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1953_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02078-2","volume":"23","author":"W Huang","year":"2025","unstructured":"Huang W, Zhang Y, Li Y, et al. Vitamin d impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps. Cell Commun Signal. 2025;23(1):104. https:\/\/doi.org\/10.1186\/s12964-025-02078-2.","journal-title":"Cell Commun Signal"},{"issue":"6","key":"1953_CR38","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002548","volume":"9","author":"S Liu","year":"2021","unstructured":"Liu S, Zhang H, Li Y, et al. S100A4 enhances protumor macrophage polarization by control of PPAR-\u03b3-dependent induction of fatty acid oxidation. J Immunother Cancer. 2021;9(6):e002548. https:\/\/doi.org\/10.1136\/jitc-2021-002548.","journal-title":"J Immunother Cancer"},{"issue":"1","key":"1953_CR39","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1158\/1078-0432.CCR-13-1279","volume":"20","author":"J Liang","year":"2014","unstructured":"Liang J, Piao Y, Holmes L, et al. Neutrophils promote the malignant glioma phenotype through S100A4. Clin Cancer Res. 2014;20(1):187\u201398. https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-1279.","journal-title":"Clin Cancer Res"},{"issue":"6","key":"1953_CR40","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/eji.202149572","volume":"52","author":"H Zhang","year":"2022","unstructured":"Zhang H, Liu S, Li Y, et al. Dysfunction of S100A4(+) effector memory CD8(+) T cells aggravates asthma. Eur J Immunol. 2022;52(6):978\u201393. https:\/\/doi.org\/10.1002\/eji.202149572.","journal-title":"Eur J Immunol"},{"issue":"2","key":"1953_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.730","volume":"11","author":"M Liu","year":"2023","unstructured":"Liu M, Liu S, Li F, et al. The miR-124-3p regulates the allergic airway inflammation and remodeling in an ovalbumin-asthmatic mouse model by inhibiting S100A4. Immunity Inflamm Dis. 2023;11(2):e730. https:\/\/doi.org\/10.1002\/iid3.730.","journal-title":"Immunity Inflamm Dis"},{"key":"1953_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.989489","volume":"9","author":"S Zou","year":"2022","unstructured":"Zou S, Huang Z, Wu J. Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps. Front Surg. 2022;9:989489. https:\/\/doi.org\/10.3389\/fsurg.2022.989489.","journal-title":"Front Surg"},{"issue":"4","key":"1953_CR43","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/jamaoto.2020.5286","volume":"147","author":"W Li","year":"2021","unstructured":"Li W, Ho J, Grayson JW, et al. Evaluation of diffuse type 2 dominant or eosinophilic chronic rhinosinusitis with corticosteroid irrigation after surgical neosinus cavity formation. JAMA Otolaryngol Head Neck Surg. 2021;147(4):360\u20137. https:\/\/doi.org\/10.1001\/jamaoto.2020.5286.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"7","key":"1953_CR44","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1007\/s00405-023-07856-7","volume":"280","author":"C Aguiar","year":"2023","unstructured":"Aguiar C, Valente P, Medeiros N, Ribeiro L, Lima N, Oliveira P. Predictive factors of revision endoscopic sinus surgery. Eur Arch Otorhinolaryngol. 2023;280(7):3265\u20139. https:\/\/doi.org\/10.1007\/s00405-023-07856-7.","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"12","key":"1953_CR45","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1007\/s00405-022-07494-5","volume":"279","author":"P Schalek","year":"2022","unstructured":"Schalek P, Hart L, Fuksa J, Guha A. Quality of life in CRSwNP: evaluation of ACCESS and Lund-Mackay computed tomography scores versus the QoL questionnaire. Eur Arch Otorhinolaryngol. 2022;279(12):5721\u20135. https:\/\/doi.org\/10.1007\/s00405-022-07494-5.","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"Suppl 3","key":"1953_CR46","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1007\/s12070-017-1154-x","volume":"71","author":"G Rai","year":"2019","unstructured":"Rai G, Roy P, Gupta N, et al. Computed tomography score an excellent marker: differentiates eosinophilic and non-eosinophilic variants of chronic rhinosinusitis with nasal polyp. Indian J Otolaryngol Head Neck Surg. 2019;71(Suppl 3):1787\u201392. https:\/\/doi.org\/10.1007\/s12070-017-1154-x.","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"1","key":"1953_CR47","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jaci.2020.08.036","volume":"147","author":"T Delemarre","year":"2021","unstructured":"Delemarre T, Holtappels G, De Ruyck N, et al. A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2021;147(1):179-188 e2. https:\/\/doi.org\/10.1016\/j.jaci.2020.08.036.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"1953_CR48","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","volume":"34","author":"Y Iwakura","year":"2011","unstructured":"Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity. 2011;34(2):149\u201362. https:\/\/doi.org\/10.1016\/j.immuni.2011.02.012.","journal-title":"Immunity"},{"key":"1953_CR49","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8609590","volume":"2022","author":"KJ Cheng","year":"2022","unstructured":"Cheng KJ, Zhou ML, Liu YC, Zhou SH. Roles played by the PI3K\/Akt\/HIF-1\u03b1 pathway and IL-17A in the Chinese subtype of chronic sinusitis with nasal polyps. Mediators Inflamm. 2022;2022:8609590. https:\/\/doi.org\/10.1155\/2022\/8609590.","journal-title":"Mediators Inflamm"},{"key":"1953_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155828","volume":"153","author":"K Matsushima","year":"2022","unstructured":"Matsushima K, Yang D, Oppenheim JJ. Interleukin-8: an evolving chemokine. Cytokine. 2022;153:155828. https:\/\/doi.org\/10.1016\/j.cyto.2022.155828.","journal-title":"Cytokine"},{"issue":"1","key":"1953_CR51","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/jpet.112.201855","volume":"347","author":"M Kaur","year":"2013","unstructured":"Kaur M, Singh D. Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1\/CXCR2. J Pharmacol Exp Ther. 2013;347(1):173\u201380. https:\/\/doi.org\/10.1124\/jpet.112.201855.","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"1953_CR52","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/eji.201847710","volume":"49","author":"MJ Dominguez-Luis","year":"2019","unstructured":"Dominguez-Luis MJ, Armas-Gonzalez E, Herrera-Garcia A, et al. L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling. Eur J Immunol. 2019;49(3):386\u201397. https:\/\/doi.org\/10.1002\/eji.201847710.","journal-title":"Eur J Immunol"},{"issue":"2","key":"1953_CR53","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/0961203316655208","volume":"26","author":"H Tyden","year":"2017","unstructured":"Tyden H, Lood C, Gullstrand B, et al. Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus. Lupus. 2017;26(2):139\u201349. https:\/\/doi.org\/10.1177\/0961203316655208.","journal-title":"Lupus"},{"key":"1953_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065213","author":"ME Clementi","year":"2023","unstructured":"Clementi ME, Sampaolese B, Di Sante G, et al. S100b expression plays a crucial role in cytotoxicity, reactive oxygen species generation and nitric oxide synthase activation induced by amyloid \u03b2-protein in an astrocytoma cell line. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24065213.","journal-title":"Int J Mol Sci"},{"key":"1953_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00447","volume":"9","author":"V Schenten","year":"2018","unstructured":"Schenten V, Plancon S, Jung N, et al. Secretion of the phosphorylated form of S100A9 from neutrophils is essential for the proinflammatory functions of extracellular S100A8\/A9. Front Immunol. 2018;9:447. https:\/\/doi.org\/10.3389\/fimmu.2018.00447.","journal-title":"Front Immunol"},{"issue":"15","key":"1953_CR56","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155581","volume":"7","author":"JR Baker","year":"2022","unstructured":"Baker JR, Fenwick PS, Koss CK, et al. IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD. JCI Insight. 2022;7(15):e155581. https:\/\/doi.org\/10.1172\/jci.insight.155581.","journal-title":"JCI Insight"},{"issue":"5","key":"1953_CR57","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/j.jaci.2017.12.972","volume":"141","author":"H Wang","year":"2018","unstructured":"Wang H, Li ZY, Jiang WX, et al. The activation and function of IL-36gamma in neutrophilic inflammation in chronic rhinosinusitis. J Allergy Clin Immunol. 2018;141(5):1646\u201358. https:\/\/doi.org\/10.1016\/j.jaci.2017.12.972.","journal-title":"J Allergy Clin Immunol"},{"issue":"Pt A","key":"1953_CR58","doi-asserted-by":"publisher","first-page":"112849","DOI":"10.1016\/j.intimp.2024.112849","volume":"142","author":"H Jingjing","year":"2024","unstructured":"Jingjing H, Tongqian W, Shirong Y, et al. S100A4 promotes experimental autoimmune encephalomyelitis by impacting microglial inflammation through TLR4\/NF-kappaB signaling pathway. Int Immunopharmacol. 2024;142(Pt A):112849. https:\/\/doi.org\/10.1016\/j.intimp.2024.112849.","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"1953_CR59","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.jaci.2024.07.006","volume":"154","author":"H Qiu","year":"2024","unstructured":"Qiu H, Liu J, Wu Q, et al. An in vitro study of the impact of IL-17A and IL-22 on ciliogenesis in nasal polyps epithelium via the Hippo-YAP pathway. J Allergy Clin Immunol. 2024;154(5):1180\u201394. https:\/\/doi.org\/10.1016\/j.jaci.2024.07.006.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-025-01953-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-025-01953-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-025-01953-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:45:18Z","timestamp":1777304718000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-025-01953-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1953"],"URL":"https:\/\/doi.org\/10.1007\/s10875-025-01953-4","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,15]]},"assertion":[{"value":"11 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics Review Committee of Shandong Provincial ENT Hospital. Informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Approval by the Institutional Review Board"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"160"}}