{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:51:48Z","timestamp":1778561508942,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Monit Comput"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s10877-019-00331-x","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T17:28:28Z","timestamp":1559928508000},"page":"461-468","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypocapnia after traumatic brain injury: how does it affect the time constant of the cerebral circulation?"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-795X","authenticated-orcid":false,"given":"Corina","family":"Puppo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-7737","authenticated-orcid":false,"given":"Magdalena","family":"Kasprowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-3532","authenticated-orcid":false,"given":"Luzius A.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Yelicich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-8681","authenticated-orcid":false,"given":"Despina Afrodite","family":"Lalou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-3938","authenticated-orcid":false,"given":"Peter","family":"Smielewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-8006","authenticated-orcid":false,"given":"Marek","family":"Czosnyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"331_CR1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.ultrasmedbio.2012.02.014","volume":"38","author":"M Kasprowicz","year":"2012","unstructured":"Kasprowicz M, Diedler J, Reinhard M, Carrera E, Steiner LA, Smielewski P, Budohoski KP, Haubrich C, Pickard JD, Czosnyka M. Time constant of the cerebral arterial bed in normal subjects. Ultrasound Med Biol. 2012;38:1129\u201337. https:\/\/doi.org\/10.1016\/j.ultrasmedbio.2012.02.014.","journal-title":"Ultrasound Med Biol"},{"key":"331_CR2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-3-7091-0956-4_4","volume":"114","author":"M Kasprowicz","year":"2012","unstructured":"Kasprowicz M, Diedler J, Reinhard M, Carrera E, Smielewski P, Budohoski KP, Sorrentino E, Haubrich C, Kirkpatrick PJ, Pickard JD, Czosnyka M. Time constant of the cerebral arterial bed. Acta Neurochir Suppl. 2012;114:17\u201321. https:\/\/doi.org\/10.1007\/978-3-7091-0956-4_4.","journal-title":"Acta Neurochir Suppl"},{"key":"331_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s12028-011-9653-1","volume":"16","author":"M Kasprowicz","year":"2012","unstructured":"Kasprowicz M, Czosnyka M, Soehle M, et al. Vasospasm shortens cerebral arterial time constant. Neurocrit Care. 2012;16:213\u20138.","journal-title":"Neurocrit Care"},{"key":"331_CR4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1179\/1743132813Y.0000000282","volume":"36","author":"C Capel","year":"2014","unstructured":"Capel C, Kasprowicz M, Czosnyka M, et al. Cerebrovascular time constant in patients suffering from hydrocephalus. Neurol Res. 2014;36:255\u201361.","journal-title":"Neurol Res"},{"key":"331_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1179\/1743132811Y.0000000040","volume":"34","author":"M Czosnyka","year":"2012","unstructured":"Czosnyka M, Richards HK, Reinhard M, et al. Cerebrovascular time constant: dependence on cerebral perfusion pressure and end-tidal carbon dioxide concentration. Neurol Res. 2012;34:17\u201324.","journal-title":"Neurol Res"},{"key":"331_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/978-3-319-18497-5_51","volume":"121","author":"A Trofimov","year":"2016","unstructured":"Trofimov A, Kalentiev G, Gribkov A, Voennov O, Grigoryeva V. Cerebrovascular time constant in patients with head injury. Acta Neurochir Suppl. 2016;121:295\u20137.","journal-title":"Acta Neurochir Suppl"},{"key":"331_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/978-3-319-22533-3_42","volume":"122","author":"M Kasprowicz","year":"2016","unstructured":"Kasprowicz M, Czosnyka M, Poplawska K, Reinhard M. Cerebral arterial time constant recorded from the MCA and PICA in normal subjects. Acta Neurochir Suppl. 2016;122:211\u20134.","journal-title":"Acta Neurochir Suppl"},{"key":"331_CR8","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1552-6569.2009.00439.x","volume":"21","author":"E Carrera","year":"2011","unstructured":"Carrera E, Kim DJ, Castellani G, et al. Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects. J Neuroimaging. 2011;21:121\u20135.","journal-title":"J Neuroimaging"},{"key":"331_CR9","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1089\/neu.2010.1377","volume":"28","author":"E Carrera","year":"2011","unstructured":"Carrera E, Steiner LA, Castellani G, et al. Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury. J Neurotrauma. 2011;28:889\u201396.","journal-title":"J Neurotrauma"},{"key":"331_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/978-3-319-65798-1_5","volume":"126","author":"M Dobrzeniecki","year":"2018","unstructured":"Dobrzeniecki M, Trofimov A, Bragin DE. Cerebral Arterial Compliance in Traumatic Brain Injury. Acta Neurochir Suppl. 2018;126:21\u20134.","journal-title":"Acta Neurochir Suppl"},{"key":"331_CR11","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1007\/s00134-004-2463-6","volume":"30","author":"LA Steiner","year":"2004","unstructured":"Steiner LA, Balestreri M, Johnston AJ, et al. Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure. Intensive Care Med. 2004;30:2180\u20137.","journal-title":"Intensive Care Med"},{"key":"331_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-3-7091-0956-4_13","volume":"114","author":"P Smielewski","year":"2012","unstructured":"Smielewski P, Czosnyka Z, Kasprowicz M, Pickard JD, Czosnyka M. ICM\u2009+\u2009: a versatile software for assessment of CSF dynamics. Acta Neurochir Suppl. 2012;114:75\u20139.","journal-title":"Acta Neurochir Suppl"},{"key":"331_CR13","unstructured":"Avezaat CJJ, Eijndhoven JHM (1984). Cerebrospinal fluid pulse pressure and craniospinal dynamics: A theoretical, clinical and experimental study. the Netherlands: The Hague: Jongbloed en Zoon."},{"key":"331_CR14","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1227\/00006123-198610000-00004","volume":"19","author":"JH van Eijndhoven","year":"1986","unstructured":"van Eijndhoven JH, Avezaat CJ. Cerebrospinal fluid pulse pressure and the pulsatile variation in cerebral blood volume: an experimental study in dogs. Neurosurgery. 1986;19:507\u201322.","journal-title":"Neurosurgery"},{"key":"331_CR15","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1161\/01.STR.22.9.1148","volume":"22","author":"R Aaslid","year":"1991","unstructured":"Aaslid R, Newell DW, Stooss R, Sorteberg W, Lindegaard KF. Assessment of cerebral autoregulation dynamics from simultaneous arterial and venous transcranial doppler recordings in humans. Stroke. 1991;22:1148\u201354.","journal-title":"Stroke"},{"key":"331_CR16","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s12028-013-9868-4","volume":"20","author":"GV Varsos","year":"2014","unstructured":"Varsos GV, Kasprowicz M, Smielewski P, Czosnyka M. Model-based indices describing cerebrovascular dynamics. Neurocrit Care. 2014;20:142\u201357.","journal-title":"Neurocrit Care"},{"key":"331_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-3-319-65798-1_29","volume":"126","author":"P Smielewski","year":"2018","unstructured":"Smielewski P, Steiner L, Puppo C, Budohoski K, Varsos GV, Czosnyka M. Effect of mild hypocapnia on critical closing pressure and other mechanoelastic parameters of the cerebrospinal system. Acta Neurochir Suppl. 2018;126:139\u201342.","journal-title":"Acta Neurochir Suppl"},{"key":"331_CR18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3171\/jns.2005.103.1.0046","volume":"103","author":"N Alperin","year":"2005","unstructured":"Alperin N, Sivaramakrishnan A, Lichtor T. Magnetic resonance imaging-based measurements of cerebrospinal fluid and blood flow as indicators of intracranial compliance in patients with Chiari malformation. J Neurosurg. 2005;103:46\u201352.","journal-title":"J Neurosurg"},{"key":"331_CR19","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1161\/01.STR.30.5.1070","volume":"30","author":"E Stolz","year":"1999","unstructured":"Stolz E, Kaps M, Kern A, Babacan SS, Dorndorf W. Transcranial color-coded duplex sonography of intracranial veins and sinuses in adults. Reference data from 130 volunteers. Stroke. 1999;30:1070\u20135.","journal-title":"Stroke"},{"key":"331_CR20","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1227\/00006123-199305000-00006","volume":"32","author":"CA Giller","year":"1993","unstructured":"Giller CA, Bowman G, Dyer H, Mootz L, Krippner W. Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery. 1993;32:737\u201341.","journal-title":"Neurosurgery"},{"issue":"594","key":"331_CR21","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1113\/JP271981","volume":"1","author":"RL Hoiland","year":"2016","unstructured":"Hoiland RL, Ainslie PN. CrossTalk proposal: the middle cerebral artery diameter does change during alterations in arterial blood gases and blood pressure. J Physiol. 2016;1(594):4073\u20135.","journal-title":"J Physiol"},{"key":"331_CR22","doi-asserted-by":"publisher","first-page":"H1030","DOI":"10.1152\/ajpheart.00761.2014","volume":"308","author":"NS Coverdale","year":"2015","unstructured":"Coverdale NS, Lalande S, Perrotta A, Shoemaker JK. Heterogeneous patterns of vasoreactivity in the middle cerebral and internal carotid arteries. Am J Physiol Heart Circ Physiol. 2015;308:H1030\u20138.","journal-title":"Am J Physiol Heart Circ Physiol."}],"container-title":["Journal of Clinical Monitoring and Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10877-019-00331-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10877-019-00331-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10877-019-00331-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:20:35Z","timestamp":1744176035000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10877-019-00331-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,7]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["331"],"URL":"https:\/\/doi.org\/10.1007\/s10877-019-00331-x","relation":{},"ISSN":["1387-1307","1573-2614"],"issn-type":[{"value":"1387-1307","type":"print"},{"value":"1573-2614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,7]]},"assertion":[{"value":"12 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. MC and PS have financial interest in a part of licensing fee for ICM\u2009+\u2009software (Cambridge Enterprise Ltd. UK).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}