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The CC16 and IL-6 were measured at T<jats:sub>1<\/jats:sub> and T<jats:sub>3<\/jats:sub>. Our results showed that the <jats:italic>P<\/jats:italic><jats:sub>mean<\/jats:sub> was increased in VI and PI group, and the <jats:italic>P<\/jats:italic><jats:sub>peak<\/jats:sub> was lower in PI group at T<jats:sub>2<\/jats:sub>. At T<jats:sub>2<\/jats:sub> and T<jats:sub>3<\/jats:sub>, the Cdyn of PI group was higher than that in other groups, and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> was increased in PI group compared with VF and VI group. At T<jats:sub>2<\/jats:sub> and T<jats:sub>3<\/jats:sub>, A-aDO<jats:sub>2<\/jats:sub> of PI and PF group was reduced than that in other groups. The Qs\/Qt was decreased in PI group compared with VF and VI group at T<jats:sub>2<\/jats:sub> and T<jats:sub>3<\/jats:sub>. At T<jats:sub>2<\/jats:sub>, <jats:italic>V<\/jats:italic><jats:sub>D<\/jats:sub><jats:italic>\/V<\/jats:italic><jats:sub>T<\/jats:sub> in PI group was decreased than other groups. At T<jats:sub>3<\/jats:sub>, the concentration of CC16 in PI group was lower compared with other groups, and IL-6 level of PI group was decreased than that in VF and VI group. In conclusion, the patients who underwent laparoscopic surgery, PCV-VG combined with individual PEEP produced favorable lung mechanics and oxygenation, and thus reducing inflammatory response and lung injury.<\/jats:p><jats:p><jats:bold>Clinical Trial registry<\/jats:bold>: chictr.org. identifier: ChiCTR-2100044928<\/jats:p>","DOI":"10.1007\/s10877-021-00750-9","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T23:59:14Z","timestamp":1630022354000},"page":"1155-1164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of pressure-controlled ventilation-volume guaranteed mode combined with individualized positive end-expiratory pressure on respiratory mechanics, oxygenation and lung injury in patients undergoing laparoscopic surgery in Trendelenburg position"],"prefix":"10.1007","volume":"36","author":[{"given":"Jianli","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saixian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songxu","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"750_CR1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/GCO.0000000000000471","volume":"30","author":"C Arvizo","year":"2018","unstructured":"Arvizo C, Mehta S, Yunker A. 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