{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:10:24Z","timestamp":1791490224117,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Monit Comput"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mixed venous oxygen saturation (SvO<jats:sub>2<\/jats:sub>) is an important variable in anesthesia and intensive care but currently requires pulmonary artery catheterization. Recently, non-invasive determination of SvO<jats:sub>2<\/jats:sub> (Capno-SvO<jats:sub>2<\/jats:sub>) using capnodynamics has shown good agreement against CO-oximetry in an animal model of modest hemodynamic changes. The purpose of the current study was to validate Capno-SvO<jats:sub>2<\/jats:sub> against CO-oximetry during major alterations in oxygen delivery. Furthermore, evaluating fiberoptic SvO<jats:sub>2<\/jats:sub> for its response to the same challenges. Eleven mechanically ventilated pigs were exposed to oxygen delivery changes: increased inhaled oxygen concentration, hemorrhage, crystalloid and blood transfusion, preload reduction and dobutamine infusion. Capno-SvO<jats:sub>2<\/jats:sub> and fiberoptic SvO<jats:sub>2<\/jats:sub> recordings were made in parallel with CO-oximetry. Respiratory quotient, needed for capnodynamic SvO<jats:sub>2<\/jats:sub>, was measured by analysis of mixed expired gases. Agreement of absolute values between CO-oximetry and Capno-SvO<jats:sub>2<\/jats:sub> and fiberoptic SvO<jats:sub>2<\/jats:sub> respectively, was assessed using Bland\u2013Altman plots. Ability of Capno- SvO<jats:sub>2<\/jats:sub> and fiberoptic SvO<jats:sub>2<\/jats:sub> to detect change compared to CO-oximetry was assessed using concordance analysis.\n The interventions caused significant hemodynamic variations. Bias between Capno-SvO<jats:sub>2<\/jats:sub> and CO-oximetry was +\u20093% points (95% limits of agreements \u2013 7 to +\u200913). Bias between fiberoptic SvO<jats:sub>2<\/jats:sub> and CO-oximetry was +\u20091% point, (95% limits of agreements \u2212\u20097 to +\u20099). Concordance rate for Capno-SvO<jats:sub>2<\/jats:sub> and fiberoptic SvO<jats:sub>2<\/jats:sub> vs. CO-oximetry was 98% and 93%, respectively. Capno-SvO<jats:sub>2<\/jats:sub> generates absolute values close to CO-oximetry. The performance of Capno-SvO<jats:sub>2<\/jats:sub> vs. CO-oximetry was comparable to the performance of fiberoptic SvO<jats:sub>2<\/jats:sub> vs. CO-oximetry. Capno-SvO<jats:sub>2<\/jats:sub> appears to be a promising tool for non-invasive SvO<jats:sub>2<\/jats:sub> monitoring.\n<\/jats:p>","DOI":"10.1007\/s10877-021-00762-5","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T17:30:48Z","timestamp":1633455048000},"page":"1315-1324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Non-invasive capnodynamic mixed venous oxygen saturation during major changes in oxygen delivery"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-4751","authenticated-orcid":false,"given":"Anders","family":"Svedmyr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Konrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Wallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-5104","authenticated-orcid":false,"given":"Magnus","family":"Hallb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-1429","authenticated-orcid":false,"given":"Per-Arne","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-0092","authenticated-orcid":false,"given":"Jacob","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"762_CR1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/bja\/aer166","volume":"107","author":"J Holm","year":"2011","unstructured":"Holm J, H\u00e5kanson E, V\u00e1nky F, Svedjeholm R. 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Mats Wallin and Mark Konrad was employed by Maquet Critical Care AB at the time of the study. Magnus Hallb\u00e4ck is employed at Maquet Critical Care AB. Anders Svedmyr and Jacob Karlsson report no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Authorization was granted from Uppsala Animal Ethics Committee (Uppsala, Sweden case number C75\/16, chairperson Erik G\u00f6ransson on August 26, 2016). The animals were handled in accordance with the animal experimentation guidelines of the Uppsala Animal Ethics Committee and Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent to participate:"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent for publication:"}}]}}