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Based on the prevalence of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage (aSAH) patients compared to traumatic brain injury (TBI), we hypothesized that the type of autoregulatory disturbance and the optimal PRx range may differ between these two conditions. The aim of this study was to determine the optimal PRx ranges in relation to functional outcome following aSAH and TBI, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this observational study, 487 aSAH patients and 413 TBI patients, treated in the neurointensive care, Uppsala, Sweden, between 2008 and 2018, were included. The percentage of good monitoring time (%GMT) of PRx was calculated within 8 intervals covering the range from -1.0 to\u2009+\u20091.0, and analyzed in relation to favorable outcome (GOS-E 5 to 8).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In multiple logistic regressions, a higher %GMTs of PRx in the intervals -1.0 to -0.5 and\u2009+\u20090.75 to\u2009+\u20091.0 were independently associated with a lower rate of favorable outcome in the aSAH cohort. In a similar analysis in the TBI cohort, only positive PRx in the interval\u2009+\u20090.75 to\u2009+\u20091.0 was independently associated with a lower rate of favorable outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Extreme PRx values in both directions were unfavorable in aSAH, possibly as high PRx could indicate proximal vasospasm with exhausted distal vasodilatory reserve, while very negative PRx could reflect myogenic hyperreactivity with suppressed cerebral blood flow. Only elevated PRx was unfavorable in TBI, possibly as pressure passive vessels may be a more predominant pathomechanism in this disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10877-024-01168-9","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T02:01:21Z","timestamp":1714788081000},"page":"1089-1099","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Optimal pressure reactivity index range is disease-specific: A comparison between aneurysmal subarachnoid hemorrhage and traumatic brain injury"],"prefix":"10.1007","volume":"38","author":[{"given":"Teodor","family":"Svedung Wettervik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Howells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"H\u00e5nell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Lew\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Enblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"1168_CR1","unstructured":"RStudio software (version 2022.12.0); R: The R Project for Statistical\u00a0Computing, Vienna, Austria"},{"key":"1168_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s12028-015-0107-z","volume":"23","author":"MJ Aries","year":"2015","unstructured":"Aries MJ, de Jong SF, van Dijk JM, Regtien J, Depreitere B, Czosnyka M, Smielewski P, Elting JW. 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