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Its performance under systemic hypoxia and variations in CO<jats:sub>2<\/jats:sub> elimination is not examined. This study aims to validate EELV-CO<jats:sub>2<\/jats:sub> against inert gas wash in\/wash out (EELV- SF6, sulfur hexafluoride) in a porcine model of stable hemodynamic conditions followed by hypoxic pulmonary vasoconstriction and inhaled nitric oxide (iNO).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Ten mechanically ventilated piglets were exposed to a hypoxic gas mixture and selective pulmonary vasoconstriction. Inhalation of nitric oxide was used to reverse the pulmonary vasoconstriction. Paired recordings of EELV-CO<jats:sub>2<\/jats:sub> and EELV-SF6, were conducted to assess their agreement of absolute values.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>EELV-CO<jats:sub>2<\/jats:sub> showed a bias of +\u20095\u00a0ml kg<jats:sup>\u2212\u20091<\/jats:sup> compared to EELV-SF6, upper limit of agreement of 11\u00a0ml kg<jats:sup>\u2212\u20091<\/jats:sup> (95%CI: 9\u201313\u00a0ml kg<jats:sup>\u2212\u20091<\/jats:sup>), lower limit of agreement \u2212\u20091\u00a0ml kg<jats:sup>\u2212\u20091<\/jats:sup> (95%CI: -3- 0\u00a0ml kg<jats:sup>\u2212\u20091<\/jats:sup>), mean percentage error 34%. Agreement between EELV-CO<jats:sub>2<\/jats:sub> and EELV-SF6 was largely constant but was affected by progressing hypoxia and reached maximum limit of agreement after iNO exposure. Re-introduction of normoxemia then stabilized bias and limits of agreement to baseline levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>EELV-CO<jats:sub>2<\/jats:sub> generates absolute values in parallel with EELV -SF6. Stressing EELV-CO<jats:sub>2<\/jats:sub> with hypoxic pulmonary vasoconstriction and iNO, transiently impairs the agreement which stabilizes once normoxemia is reestablished.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10877-024-01251-1","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T15:44:24Z","timestamp":1734018264000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Capnodynamic determination of end-expiratory lung volume in a porcine model of hypoxic pulmonary vasoconstriction"],"prefix":"10.1007","volume":"39","author":[{"given":"Aron","family":"T\u00f6rnwall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Wallin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-5104","authenticated-orcid":false,"given":"Magnus","family":"Hallb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-1429","authenticated-orcid":false,"given":"Per-Arne","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-0092","authenticated-orcid":false,"given":"Jacob","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"issue":"6","key":"1251_CR1","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1093\/bja\/aex192","volume":"119","author":"C Nestler","year":"2017","unstructured":"Nestler C, Simon P, Petroff D, Hammerm\u00b8ller S, Kamrath D, Wolf S, et al. 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Mats Wallin was employed by Maquet Critical Care AB at the time of the study. Magnus Hallb\u00e4ck is employed at Maquet Critical Care AB. Jacob Karlsson and Aron T\u00f6rnvall report no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}