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At the bedside, there can be reluctance or uncertainty about when to initiate EBP, and there is no standard agreement on which goals to pursue, what prescriptions to use to achieve those goals, or which recommendations to follow to prevent complications. Furthermore, an accurate analysis of why clinical goals are not achieved or how often the patient should be reassessed to readjust the EBP prescription is not currently standardized. This narrative review describes the main actions characterizing a quality improvement program for EBP in the ICU, which took place at the University of Florence and was subsequently adopted at the national level. The pillars of this program were: (1) definition, implementation, and dissemination of information and communication technology tools aimed at objectively measuring results at the bedside, supporting dynamic prescribing and precision medicine, and promoting advances in knowledge in this field; (2) creation of a national multi-professional network of clinical users and researchers in EBP; (3) promotion and maintenance of technical and non-technical skills in EBP based on the reformulation of advanced academic training in this field.<\/jats:p>","DOI":"10.1007\/s10877-025-01396-7","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:15:03Z","timestamp":1765534503000},"page":"735-745","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Program of quality improvement for extracorporeal blood purification therapies in the intensive care unit"],"prefix":"10.1007","volume":"40","author":[{"given":"Matteo","family":"Cecchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Pomar\u00e8 Montin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Fioccola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Bocciero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Scir\u00e8 Calabrisotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Autieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Benelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Geppetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaccaria","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"1396_CR1","doi-asserted-by":"publisher","DOI":"10.5339\/qmj.2020.22","volume":"2020","author":"M Asim","year":"2020","unstructured":"Asim M, Amin F, El-Menyar A. 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M.C. was an employee of Baxter Italia and he was a PhD student at the University of Florence under the supervision of Prof. Gianluca Villa when the study was underway. M.C. disclosed that these interests have not interfered with the analysis and interpretation of the data and the preparation and publishing of the manuscript. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. The other authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The present study was approved by the local Ethics Committee, \u201cComitato Etico Area Vasta Centro, Regione Toscana,\u201d Florence, Italy (CEAVC 14334, NCT03807414). Being an observational study, enrolled patients did not receive additional medical, pharmacological, or behavioral interventions other than those administered in routine clinical practice. This research study was conducted in accordance with the principles laid out in the original Declaration of Helsinki and its later amendments. Data were captured in REDCap with early pseudonymization and center\u2011scoped access controls; servers are hosted in secured university facilities with administrator\u2011only physical access. Where capacity was lacking, consent was obtained from a guardian or legally authorized surrogate in accordance with Italian Decree 101\/2018 implementing GDPR (EU 2016\/679); patients regaining capacity could withdraw at any time.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement\/Ethics approval"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}