{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:55:35Z","timestamp":1790585735745,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Monit Comput"],"DOI":"10.1007\/s10877-026-01478-0","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:35:54Z","timestamp":1790483754000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nociception monitoring during cardiac surgery with cardiopulmonary bypass: limitations and future directions"],"prefix":"10.1007","author":[{"given":"Vladislav","family":"Rogozov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Van\u011bk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Bla\u017eejov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"1478_CR1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/bja\/85.1.109","volume":"85","author":"JP Desborough","year":"2000","unstructured":"Desborough JP. The stress response to trauma and surgery. Br J Anaesth. 2000;85:109\u201317. https:\/\/doi.org\/10.1093\/bja\/85.1.109.","journal-title":"Br J Anaesth"},{"key":"1478_CR2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1213\/ane.0b013e3181a90adc","volume":"109","author":"GS Murphy","year":"2009","unstructured":"Murphy GS, Szokol JW, Marymont JH, Greenberg SB, Avram MJ, Vender JS, Sherwani SS, Nisman M, Doroski V. Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients. Anesth Analg. 2009;109:311\u20139. https:\/\/doi.org\/10.1213\/ane.0b013e3181a90adc.","journal-title":"Anesth Analg"},{"key":"1478_CR3","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1053\/j.jvca.2018.05.053","volume":"33","author":"LE Kwanten","year":"2019","unstructured":"Kwanten LE, O\u2019Brien B, Anwar S. Opioid-based anesthesia and analgesia for adult cardiac surgery: history and narrative review of the literature. J Cardiothorac Vasc Anesth. 2019;33:808\u201316. https:\/\/doi.org\/10.1053\/j.jvca.2018.05.053.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1478_CR4","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1378\/chest.107.4.1125","volume":"107","author":"TS Hall","year":"1995","unstructured":"Hall TS. The pathophysiology of cardiopulmonary bypass. The risks and benefits of hemodilution. Chest. 1995;107:1125\u201333. https:\/\/doi.org\/10.1378\/chest.107.4.1125.","journal-title":"Chest"},{"key":"1478_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S0889-8537(03)00039-7","volume":"21","author":"T Pintar","year":"2003","unstructured":"Pintar T, Collard CD. The systemic inflammatory response to cardiopulmonary bypass. Anesthesiol Clin North Am. 2003;21:453\u201364. https:\/\/doi.org\/10.1016\/S0889-8537(03)00039-7.","journal-title":"Anesthesiol Clin North Am"},{"key":"1478_CR6","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1378\/chest.112.3.676","volume":"112","author":"S Wan","year":"1997","unstructured":"Wan S, LeClerc JL, Vincent JL. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest. 1997;112:676\u201392. https:\/\/doi.org\/10.1378\/chest.112.3.676.","journal-title":"Chest"},{"key":"1478_CR7","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1097\/00000542-199810000-00023","volume":"89","author":"IJ Rampil","year":"1998","unstructured":"Rampil IJ. A primer for EEG signal processing in anesthesia. Anesthesiology. 1998;89:980\u20131002. https:\/\/doi.org\/10.1097\/00000542-199810000-00023.","journal-title":"Anesthesiology"},{"key":"1478_CR8","doi-asserted-by":"publisher","first-page":"e312","DOI":"10.1016\/j.bja.2019.03.024","volume":"123","author":"T Ledowski","year":"2019","unstructured":"Ledowski T. Objective monitoring of nociception: a review of current commercial solutions. Br J Anaesth. 2019;123:e312\u201321. https:\/\/doi.org\/10.1016\/j.bja.2019.03.024.","journal-title":"Br J Anaesth"},{"key":"1478_CR9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10877-012-9354-0","volume":"26","author":"M Jeanne","year":"2012","unstructured":"Jeanne M, Cl\u00e9ment C, De Jonckheere J, Logier R, Tavernier B. Variations of the analgesia nociception index during general anaesthesia for laparoscopic abdominal surgery. J Clin Monit Comput. 2012;26:289\u201394. https:\/\/doi.org\/10.1007\/s10877-012-9354-0.","journal-title":"J Clin Monit Comput"},{"key":"1478_CR10","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/bja\/aem004","volume":"98","author":"M Huiku","year":"2007","unstructured":"Huiku M, Uutela K, van Gils M, Korhonen I, Kym\u00e4l\u00e4inen M, Meril\u00e4inen P, Paloheimo M, Rantanen M, Takala P, Vierti\u00f6-Oja H, Yli-Hankala A. Assessment of surgical stress during general anaesthesia. Br J Anaesth. 2007;98:447\u201355. https:\/\/doi.org\/10.1093\/bja\/aem004.","journal-title":"Br J Anaesth"},{"key":"1478_CR11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/ALN.0000000000001130","volume":"125","author":"R Edry","year":"2016","unstructured":"Edry R, Recea V, Dikust Y, Sessler DI. Preliminary intraoperative validation of the nociception level index: a noninvasive nociception monitor. Anesthesiology. 2016;125:193\u2013203. https:\/\/doi.org\/10.1097\/ALN.0000000000001130.","journal-title":"Anesthesiology"},{"key":"1478_CR12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/aas.12359","volume":"58","author":"EW Jensen","year":"2014","unstructured":"Jensen EW, Valencia JF, L\u00f3pez A, Anglada T, Agust\u00ed M, Ramos Y, Serra R, Jospin M, Pineda P, Gambus P. Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia. Acta Anaesthesiol Scand. 2014;58:933\u201341. https:\/\/doi.org\/10.1111\/aas.12359.","journal-title":"Acta Anaesthesiol Scand"},{"key":"1478_CR13","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5507\/bp.2022.045","volume":"168","author":"V Rogozov","year":"2024","unstructured":"Rogozov V, Vanek T, Maly M, Rocek J, Kacer P. The nociceptive response during adult cardiac surgery measured by the qNOX index: a feasibility study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024;168:62\u20137. https:\/\/doi.org\/10.5507\/bp.2022.045.","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"1478_CR14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.22514\/sv.2023.070","volume":"20","author":"V Rogozov","year":"2024","unstructured":"Rogozov V, Vanek T, Maly M, Kacer P, Musil V. Lower dose of sufentanil was associated with higher plasmatic level of cortisol in patients undergoing elective cardiac surgery at the same depth of anaesthesia: a prospective randomised pilot study. Signa Vitae. 2024;20:71\u20136. https:\/\/doi.org\/10.22514\/sv.2023.070.","journal-title":"Signa Vitae"},{"key":"1478_CR15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/bja\/aeg178","volume":"91","author":"L Barvais","year":"2003","unstructured":"Barvais L, Engelman E, Eba JM, Coussaert E, Cantraine F, Kenny GN. Effect site concentrations of remifentanil and pupil response to noxious stimulation. Br J Anaesth. 2003;91:347\u201352. https:\/\/doi.org\/10.1093\/bja\/aeg178.","journal-title":"Br J Anaesth"},{"key":"1478_CR16","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.1213\/01.ane.0000269512.82836.c9","volume":"105","author":"KH Shelley","year":"2007","unstructured":"Shelley KH. Photoplethysmography: beyond the calculation of arterial oxygen saturation and heart rate. Anesth Analg. 2007;105:S31\u20136. https:\/\/doi.org\/10.1213\/01.ane.0000269512.82836.c9.","journal-title":"Anesth Analg"},{"key":"1478_CR17","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1213\/01.ANE.0000048822.27698.28","volume":"96","author":"S Kongsayreepong","year":"2003","unstructured":"Kongsayreepong S, Chaibundit C, Chadpaibool J, Komoltri C, Suraseranivongse S, Suwannanonda P, Raksamanee EO, Noocharoen P, Silapadech A, Parakkamodom S, Pum-In C, Sojeoyya L. Predictor of core hypothermia and the surgical intensive care unit stay after cardiac surgery. Anesth Analg. 2003;96:826\u201333. https:\/\/doi.org\/10.1213\/01.ANE.0000048822.27698.28.","journal-title":"Anesth Analg"},{"key":"1478_CR18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/MCC.0000000000000743","volume":"26","author":"B Levy","year":"2020","unstructured":"Levy B, Klein T, Kimmoun A. Vasopressor use in cardiogenic shock. Curr Opin Crit Care. 2020;26:411\u20136. https:\/\/doi.org\/10.1097\/MCC.0000000000000743.","journal-title":"Curr Opin Crit Care"},{"key":"1478_CR19","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s10877-025-01377-w","volume":"39","author":"C Balan","year":"2025","unstructured":"Balan C, Barbulescu RT, Dumitrache A, Fodoroiu A, Morosanu B, Nica A, Stanculea I, Stoian I, Valeanu L, Wong A, Bubenek-Turconi SI. Nociception level index response to pacemaker stimulation. J Clin Monit Comput. 2025;39:1309\u201316. https:\/\/doi.org\/10.1007\/s10877-025-01377-w.","journal-title":"J Clin Monit Comput"},{"key":"1478_CR20","doi-asserted-by":"publisher","first-page":"365","DOI":"10.5114\/ait\/213842","volume":"57","author":"JK Danel","year":"2025","unstructured":"Danel JK, Rosada-Kurasinska J, Copik MM, Zdanowski S, Gola W, Misio\u0142ek H, Bartkowska-\u015aniatkowska A, Bia\u0142ka S. Objective monitoring of acute pain and nociception in anaesthesia and intensive care: evidence and applications. Anaesthesiol Intensive Ther. 2025;57:365\u201380. https:\/\/doi.org\/10.5114\/ait\/213842.","journal-title":"Anaesthesiol Intensive Ther"},{"key":"1478_CR21","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s10877-019-00362-4","volume":"34","author":"FS Meijer","year":"2020","unstructured":"Meijer FS, Niesters M, van Velzen M, Martini CH, Olofsen E, Edry R, Sessler DI, van Dorp ELA, Dahan A, Boon M. Does nociception monitor-guided anesthesia affect opioid consumption? A systematic review of randomized controlled trials. J Clin Monit Comput. 2020;34:629\u201341. https:\/\/doi.org\/10.1007\/s10877-019-00362-4.","journal-title":"J Clin Monit Comput"},{"key":"1478_CR22","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.bja.2024.09.020","volume":"134","author":"MAJ Snoek","year":"2025","unstructured":"Snoek MAJ, van den Berg VJ, Dahan A, Boon M. Comparison of different monitors for measurement of nociception during general anaesthesia: a network meta-analysis of randomised controlled trials. Br J Anaesth. 2025;134:180\u201391. https:\/\/doi.org\/10.1016\/j.bja.2024.09.020.","journal-title":"Br J Anaesth"},{"key":"1478_CR23","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/s12871-026-03704-3","volume":"26","author":"EJ Oh","year":"2026","unstructured":"Oh EJ, Kim J, Kwon EJ, Ahn JH, Shim JG, Jun J, Kim D, Kim GS. Agreement between analgesia nociception index (ANI) and surgical pleth index (SPI) in assessing nociception under varying systemic vascular resistance conditions. BMC Anesthesiol. 2026;26:288. https:\/\/doi.org\/10.1186\/s12871-026-03704-3.","journal-title":"BMC Anesthesiol"}],"container-title":["Journal of Clinical Monitoring and Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10877-026-01478-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10877-026-01478-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10877-026-01478-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:03:55Z","timestamp":1790582635000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10877-026-01478-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":23,"alternative-id":["1478"],"URL":"https:\/\/doi.org\/10.1007\/s10877-026-01478-0","relation":{},"ISSN":["1573-2614"],"issn-type":[{"value":"1573-2614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"12 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}