{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:07:10Z","timestamp":1781068030278,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Fluoresc"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s10895-022-02893-7","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T08:03:54Z","timestamp":1653638634000},"page":"1669-1678","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Naked Eye Chemosensor and In Vivo Chelating Activity of Iron (III) By Bromopyridine Quinoxaline (BPQ)"],"prefix":"10.1007","volume":"32","author":[{"given":"Zahra","family":"Hashemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8769-9912","authenticated-orcid":false,"given":"Mohammad Ali","family":"Ebrahimzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pourya","family":"Biparva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"2893_CR1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4236\/jacen.2012.11006","volume":"1","author":"KH Beak","year":"2012","unstructured":"Beak KH, Skinner DZ (2012) Production of reactive oxygen species by freezing stress and the protective roles of antioxidant enzymes in plants. J Agric Chem Environ 1:34\u201340. https:\/\/doi.org\/10.4236\/jacen.2012.11006","journal-title":"J Agric Chem Environ"},{"key":"2893_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/0470845791","volume-title":"Inorganic biochemistry of iron metabolism: from molecular mechanisms to clinical consequences","author":"R Crichton","year":"2001","unstructured":"Crichton R (2001) Inorganic biochemistry of iron metabolism: from molecular mechanisms to clinical consequences, 2nd edn. John Wiley & Sons, England","edition":"2"},{"key":"2893_CR3","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001","volume-title":"Free radicals in biology and medicine","author":"B Halliwell","year":"2015","unstructured":"Halliwell B, Gutteridge JM (2015) Free radicals in biology and medicine, 5th edn. Oxford University Press, United Kingdom","edition":"5"},{"key":"2893_CR4","unstructured":"Hoffman R, JR Benz EJ, Silberstein LE, Heslop H, Anastasi J, Weitz J (2013) Hematology: basic principles and practice, six ed., Elsevier Health Sciences"},{"key":"2893_CR5","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1258\/0007142991902600","volume":"55","author":"M Olivares","year":"1999","unstructured":"Olivares M, Walter T, Hertrampf E, Pizarro F (1999) Anaemia and iron deficiency disease in children. Br Med Bull 55:534\u2013543. https:\/\/doi.org\/10.1258\/0007142991902600","journal-title":"Br Med Bull"},{"key":"2893_CR6","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/iub.1602","volume":"69","author":"M Sanchez","year":"2017","unstructured":"Sanchez M, Sabio L, Galvez N, Capdevila M, Dominguez JM (2017) Iron chemistry at the service of life. IUBMB Life 69:382\u2013388. https:\/\/doi.org\/10.1002\/iub.1602","journal-title":"IUBMB Life"},{"key":"2893_CR7","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/0002-9343(67)90276-8","volume":"42","author":"RM Bannerman","year":"1967","unstructured":"Bannerman RM, Keusch G, Kreimer-Birnbaum M, Vance VK, Vaughan S (1967) Thalassemia intermedia, with iron overload, cardiac failure, diabetes mellitus, hypopituitarism and porphyrinuria. Am J Med 42:476\u2013486. https:\/\/doi.org\/10.1016\/0002-9343(67)90276-8","journal-title":"Am J Med"},{"key":"2893_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nchembio.1416","volume":"10","author":"SJ Dixon","year":"2014","unstructured":"Dixon SJ, Stockwell BR (2014) The role of iron and reactive oxygen species in cell death. Nat Chem Biol 10:9\u201317. https:\/\/doi.org\/10.1038\/nchembio.1416","journal-title":"Nat Chem Biol"},{"key":"2893_CR9","doi-asserted-by":"publisher","first-page":"6371","DOI":"10.1039\/C2DT12159J","volume":"41","author":"T Zhou","year":"2012","unstructured":"Zhou T, Ma Y, Kong X, Hider RC (2012) Design of iron chelators with therapeutic application Design of iron chelators with therapeutic application. Dalton Trans 41:6371\u20136389. https:\/\/doi.org\/10.1039\/C2DT12159J","journal-title":"Dalton Trans"},{"key":"2893_CR10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.tjog.2019.11.018","volume":"59","author":"MG Piccioni","year":"2020","unstructured":"Piccioni MG, Capone C, Vena F, Del Negro V, Schiavi MC, D\u2019Ambrosio V, Giancotti A, Smacchia MP, Brunelli R (2020) Use of deferoxamine (DFO) in transfusion-dependent \u03b2-thalassemia during pregnancy: A retrospective study. Taiwan J Obstet Gynecol 59:120\u2013122. https:\/\/doi.org\/10.1016\/j.tjog.2019.11.018","journal-title":"Taiwan J Obstet Gynecol"},{"key":"2893_CR11","doi-asserted-by":"publisher","first-page":"0211942","DOI":"10.1371\/journal.pone.0211942","volume":"14","author":"NF Olivieri","year":"2019","unstructured":"Olivieri NF, Sabouhanian A, Gallie BL (2019) Single-center retrospective study of the effectiveness and toxicity of the oral iron chelating drugs deferiprone and deferasirox. PLoS ONE 14:0211942. https:\/\/doi.org\/10.1371\/journal.pone.0211942","journal-title":"PLoS ONE"},{"issue":"1","key":"2893_CR12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1159\/000494487","volume":"141","author":"H Dou","year":"2019","unstructured":"Dou H, Qin Y, Chen G, Zhao Y (2019) Effectiveness and safety of deferasirox in thalassemia with iron overload: a meta-analysis. Acta Haematol 141(1):32\u201342. https:\/\/doi.org\/10.1159\/000494487","journal-title":"Acta Haematol"},{"key":"2893_CR13","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1517\/13543776.2012.724677","volume":"22","author":"M Gonzalez","year":"2012","unstructured":"Gonzalez M, Cerecetto H (2012) Quinoxaline derivatives: a patent review (2006\u2013present). Expert Opin Ther Pat 22:1289\u20131302. https:\/\/doi.org\/10.1517\/13543776.2012.724677","journal-title":"Expert Opin Ther Pat"},{"key":"2893_CR14","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.ejmech.2014.06.058","volume":"97","author":"JA Pereira","year":"2015","unstructured":"Pereira JA, Pessoa AM, Cordeoro MND, Fernandes R, Prudencio C, Noronha JP, Vieira M (2015) Quinoxaline, its derivatives and applications: A State of the Art review. Eur J Med Chem 97:664\u2013672. https:\/\/doi.org\/10.1016\/j.ejmech.2014.06.058","journal-title":"Eur J Med Chem"},{"key":"2893_CR15","doi-asserted-by":"publisher","unstructured":"Lin J, Wang P, Zhang Z, Xue G, Zha D, Wang J, Xu X, Li Z (2020) Facile synthesis and anti-proliferative activity evaluation of quinoxaline derivatives.\u00a0Synth Commun 5:823\u2013830. https:\/\/doi.org\/10.1080\/00397911.2020.1714054","DOI":"10.1080\/00397911.2020.1714054"},{"key":"2893_CR16","doi-asserted-by":"publisher","first-page":"3824","DOI":"10.1021\/jm0009686","volume":"43","author":"D Catazari","year":"2000","unstructured":"Catazari D, Colotta V, Varano F, Cecchi L, Filacchioni G, Galli A, Costagli C (2000) 7-Chloro-4, 5-dihydro-8-(1, 2, 4-triazol-4-yl)-4-oxo-1, 2, 4-triazolo [1, 5-a] quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists. J Med Chem 43:3824\u20133826. https:\/\/doi.org\/10.1021\/jm0009686","journal-title":"J Med Chem"},{"key":"2893_CR17","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1080\/00958972.2013.782008","volume":"66","author":"CJ Dhanaraj","year":"2013","unstructured":"Dhanaraj CJ, Johnson J, Joseph J, Joseyphus RS (2013) Quinoxaline-based Schiff base transition metal complexes. J Coord Chem 66:1416\u20131450. https:\/\/doi.org\/10.1080\/00958972.2013.782008","journal-title":"J Coord Chem"},{"key":"2893_CR18","doi-asserted-by":"publisher","first-page":"7183","DOI":"10.1016\/j.tetlet.2005.08.080","volume":"46","author":"RS Bhosale","year":"2005","unstructured":"Bhosale RS, Sarda SR, Ardhapure SS, Jadhav WN, Bhusare SR, Pawar RP (2005) An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using molecular iodine as the catalyst. Tetrahedron Lett 46:7183\u20137186. https:\/\/doi.org\/10.1016\/j.tetlet.2005.08.080","journal-title":"Tetrahedron Lett"},{"key":"2893_CR19","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1021\/ja01384a032","volume":"51","author":"BB Corson","year":"1929","unstructured":"Corson BB, Mcallister RW (1929) Oxidation of benzoins to diketones with iodines. J Am Chem Soc 51:2822\u20132825. https:\/\/doi.org\/10.1021\/ja01384a032","journal-title":"J Am Chem Soc"},{"key":"2893_CR20","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1021\/op400292m","volume":"17","author":"S Karlsson","year":"2013","unstructured":"Karlsson S, Lindberg J, Soren H (2013) Evaluation and development of practical routes to an enantiomerically pure C2-Symmetric diamine building block. Org Process Res Dev 17:1552\u20131560. https:\/\/doi.org\/10.1021\/op400292m","journal-title":"Org Process Res Dev"},{"key":"2893_CR21","first-page":"17","volume":"1","author":"MH Mousavi","year":"2013","unstructured":"Mousavi MH, Seyfi I, Saveh I (2013) Preparation of \u03b1-Hydroxy ketones from aromatic aldehydes. J Org Chem 1:17\u201323","journal-title":"J Org Chem"},{"key":"2893_CR22","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1166\/sl.2019.4137","volume":"17","author":"ZK Kordi","year":"2019","unstructured":"Kordi ZK, Ziarani GM, Badiei A, Lashgari N (2019) Synthesis of 1, 4-Dihydropyridine as a Fluorescent and Colorimetric chemosensor for detection of Fe3+ ion. Sensor Lett 17:747\u2013754. https:\/\/doi.org\/10.1166\/sl.2019.4137","journal-title":"Sensor Lett"},{"key":"2893_CR23","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.snb.2013.03.062","volume":"182","author":"VK Gupta","year":"2013","unstructured":"Gupta VK, Singh A, Ganjali K, Norouzi MR, Faridbod P, Mergu F, Comparative N (2013) Study of colorimetric sensors based on newly synthesized Schiff bases. Sens Actuators B Chem 182:642\u2013665. https:\/\/doi.org\/10.1016\/j.snb.2013.03.062","journal-title":"Sens Actuators B Chem"},{"key":"2893_CR24","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1039\/C9AY00515C","volume":"11","author":"H Jain","year":"2019","unstructured":"Jain H, Deswal N, Joshi A, Ramachandran CN, Kumar R (2019) Triazole-appended pyrano [2, 3-c] pyrazolone based colorimetric chemosensors for recognition of Fe3+ ions and their molecular logic gate behavior. Anal Methods 11:3230\u20133243. https:\/\/doi.org\/10.1039\/C9AY00515C","journal-title":"Anal Methods"},{"key":"2893_CR25","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1134\/S1061934811060153","volume":"66","author":"P Soni","year":"2011","unstructured":"Soni P, Sar SK, Kamavisdar A, Patel R (2011) Simple and sensitive spectrophotometric method for determination of tricyclic antidepressant imipramine using Fe (III)-SCN\u2212 complex. J Anal Chem 66:596\u2013599. https:\/\/doi.org\/10.1134\/S1061934811060153","journal-title":"J Anal Chem"},{"issue":"1","key":"2893_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0278-6915(99)00125-8","volume":"38","author":"J Heimbach","year":"2000","unstructured":"Heimbach J, Rieth S, Mihamdshah F, Slesinski R, Samuel-Fernando P, Sheeha T, Dickmann R, Borzelleca J (2000) Safety assessment of iron EDTA [sodium iron (Fe3+) ethylenediaminetetraacetic acid]: summary of toxicological, fortification and exposure data. Food Chem Toxicol 38(1):99\u2013111. https:\/\/doi.org\/10.1016\/S0278-6915(99)00125-8","journal-title":"Food Chem Toxicol"},{"key":"2893_CR27","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.talanta.2016.03.096","volume":"154","author":"S Tang","year":"2016","unstructured":"Tang S, Chang Y, Shen W, Lee HK (2016) Selective extraction by dissolvable (nitriloacetic acid-nickel)-layered double hydroxide coupled with reaction with potassium thiocyanate for sensitive detection of iron (III). Talanta 154:416\u2013422. https:\/\/doi.org\/10.1016\/j.talanta.2016.03.096","journal-title":"Talanta"},{"key":"2893_CR28","doi-asserted-by":"publisher","first-page":"4804","DOI":"10.1039\/C4RA11561A","volume":"5","author":"M Khalili","year":"2015","unstructured":"Khalili M, Ebrahimzadeh MA, Kosaryan M, Abbasi A, Azadbakht M (2015) Iron chelation and liver disease healing activity of edible mushroom (Cantharellus cibarius), in vitro and in vivo assays. RSC Adv 5:4804\u20134810. https:\/\/doi.org\/10.1039\/C4RA11561A","journal-title":"RSC Adv"},{"key":"2893_CR29","doi-asserted-by":"publisher","first-page":"26144","DOI":"10.1039\/C8RA04451A","volume":"46","author":"S Eslami","year":"2018","unstructured":"Eslami S, Ebrahimzadeh MA, Biparva P (2018) Green synthesis of safe zero valent iron nanoparticles by Myrtus communis leaf extract as an effective agent for reducing excessive iron in iron-overloaded mice, a thalassemia model. RSC Adv 46:26144\u201326155. https:\/\/doi.org\/10.1039\/C8RA04451A","journal-title":"RSC Adv"},{"key":"2893_CR30","doi-asserted-by":"publisher","first-page":"6345","DOI":"10.1016\/j.tetlet.2005.07.026","volume":"46","author":"SV More","year":"2005","unstructured":"More SV, Sastry M, Wang CC, Yao CF (2005) Molecular iodine: a powerful catalyst for the easy and efficient synthesis of quinoxalines. Tetrahedron lett 46:6345\u20136348. https:\/\/doi.org\/10.1016\/j.tetlet.2005.07.026","journal-title":"Tetrahedron lett"},{"key":"2893_CR31","doi-asserted-by":"publisher","first-page":"5164","DOI":"10.3390\/molecules17055164","volume":"17","author":"JJ Morales-Castellanos","year":"2012","unstructured":"Morales-Castellanos JJ, Ram\u00edrez-Hern\u00e1ndez K, G\u00f3mez-Flores NS, Rodas-Su\u00e1rez OR, Peralta-Cruz J (2012) Microwave-assisted solvent-free synthesis and in vitro antibacterial screening of quinoxalines and pyrido [2, 3b] pyrazines. Molecules 17:5164\u20135176. https:\/\/doi.org\/10.3390\/molecules17055164","journal-title":"Molecules"},{"key":"2893_CR32","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.snb.2016.06.123","volume":"237","author":"Y Liu","year":"2016","unstructured":"Liu Y, Zhang J, Ru J, Yao X, Yang Y, Li X, Tanga X, Zhang G, Liu W (2016) A naked-eye visible and turn-on fluorescence probe for Fe3+ and its bioimaging application in living cells. Sens Actuators B Chem 237:501\u2013508. https:\/\/doi.org\/10.1016\/j.snb.2016.06.123","journal-title":"Sens Actuators B Chem"},{"issue":"4","key":"2893_CR33","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1124\/pr.57.4.2","volume":"57","author":"DS Kalinowski","year":"2005","unstructured":"Kalinowski DS, Richardson DR (2005) The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol Rev 57(4):547\u2013583","journal-title":"Pharmacol Rev"},{"key":"2893_CR34","doi-asserted-by":"publisher","unstructured":"Golchoubian H, Mardani HR, Bruno G, Rudbari HA (2013) Effect of alkyl group on the structure of heterodinuclear Zn (II)\u2013Cu (II) and Zn (II)\u2013Ni (II) complexes derived from unsymmetrical phenol-based dicompartmental macro-acyclic ligands. J Iran Chem Soc 10:29\u201341. https:\/\/doi.org\/10.1007\/s13738-012-0125-0","DOI":"10.1007\/s13738-012-0125-0"},{"key":"2893_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/195074","volume":"16","author":"CS Dilip","year":"2013","unstructured":"Dilip CS, Manikandan K, Subahashini D, Thiruneelakandan R (2013) Synthesis, Spectroscopic Characterisation, and Biopotential and DNA Cleavage Applications of Mixed Ligand 4-N, N-Dimethylaminopyridine Metal Complexes. J Chem 16:1\u201316. https:\/\/doi.org\/10.1155\/2013\/195074","journal-title":"J Chem"}],"container-title":["Journal of Fluorescence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10895-022-02893-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10895-022-02893-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10895-022-02893-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:14:21Z","timestamp":1661328861000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10895-022-02893-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2893"],"URL":"https:\/\/doi.org\/10.1007\/s10895-022-02893-7","relation":{},"ISSN":["1053-0509","1573-4994"],"issn-type":[{"value":"1053-0509","type":"print"},{"value":"1573-4994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,27]]},"assertion":[{"value":"8 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were approved by the Animal Experiments Committee of the Animal Experimental Ethical Committee of Mazandaran University of Medical Sciences (Approval No. 911, 2016).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable<b>.<\/b>","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}