{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T07:55:01Z","timestamp":1788681301226,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21702178"],"award-info":[{"award-number":["21702178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Fluoresc"],"DOI":"10.1007\/s10895-024-03601-3","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:03:05Z","timestamp":1706774585000},"page":"1163-1169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Highly Selective Fluorescent Probe for Hydrogen Sulfide and its Application in Living Cell"],"prefix":"10.1007","volume":"35","author":[{"given":"Zhiyu","family":"Ju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"3601_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/6043038","volume":"2016","author":"ZZ Xie","year":"2016","unstructured":"Xie ZZ, Liu Y, Bian J-S (2016) Hydrogen Sulfide and Cellular Redox Homeostasis. Oxidative Med Cell Longev 2016:1\u201312","journal-title":"Oxidative Med Cell Longev"},{"issue":"5","key":"3601_CR2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1093\/occmed\/46.5.367","volume":"46","author":"TL Guidotti","year":"1996","unstructured":"Guidotti TL (1996) Hydrogen Sulphide. Occup Med 46(5):367\u2013371","journal-title":"Occup Med"},{"key":"3601_CR3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1089\/ars.2011.4401","volume":"17","author":"KR Olson","year":"2011","unstructured":"Olson KR (2011) A practical look at the chemistry and biology of hydrogen sulfide. Antioxid Redox Signal 17:32\u201344","journal-title":"Antioxid Redox Signal"},{"key":"3601_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","volume":"51","author":"L Li","year":"2011","unstructured":"Li L, Rose P, Moore PK (2011) Hydrogen sulfide and cell signaling. Annu Rev Pharmacol 51:169\u2013187","journal-title":"Annu Rev Pharmacol"},{"key":"3601_CR5","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","volume":"237","author":"R Hosoki","year":"1997","unstructured":"Hosoki R, Matsuki N, Kimura H (1997) The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 237:527\u2013531","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3601_CR6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1177\/002215540305100311","volume":"51","author":"K Robert","year":"2003","unstructured":"Robert K, Vialard F, Thiery E, Toyama K, Sinet PM, Janel N, London J (2003) Expression of the Cystathionine synthase (CBS) Gene during Mouse Development and Immunolocalization in Adult Brain. J Histochem Cytochemistry 51(3):363\u2013371","journal-title":"J Histochem Cytochemistry"},{"issue":"2","key":"3601_CR7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","volume":"9","author":"LF Hu","year":"2010","unstructured":"Hu LF, Lu M, Tiong CX, Dawe G, Hu G, Bian J-S (2010) Neuroprotective effects of hydrogen sulfide on Parkinson\u2019sdisease rat models. Aging Cell 9(2):135\u2013146","journal-title":"Aging Cell"},{"issue":"6","key":"3601_CR8","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1089\/ars.2011.4507","volume":"17","author":"M Lu","year":"2012","unstructured":"Lu M, Zhao FF, Tang J-, Su CJ, Fan Y, Ding J-H, Bian J-S, Hu G (2012) The neuroprotection of hydrogen sulfide against MPTP-induced dopaminergic neuron degeneration involves uncoupling protein 2 rather than ATPsensitive potassium channels. Antioxid Redox Signal 17(6):849\u2013859","journal-title":"Antioxid Redox Signal"},{"issue":"1\u20133","key":"3601_CR9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ejphar.2009.05.023","volume":"616","author":"TT Pan","year":"2009","unstructured":"Pan TT, Chen YQ, Bian JS (2009) All in the timing: a comparison between the cardioprotection induced by H2S preconditioning and post-infarction treatment. Eur J Pharmacol 616(1\u20133):160\u2013165","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"3601_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.yjmcc.2005.10.003","volume":"40","author":"TT Pan","year":"2006","unstructured":"Pan TT, Feng ZN, Lee SW, Moore PK, Bian JS (2006) Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes. J Mol Cell Cardiol 40(1):119\u2013130","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"3601_CR11","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1681\/ASN.2009090949","volume":"21","author":"M Lu","year":"2010","unstructured":"Lu M, Liu YH, Goh HS et al (2010) Hydrogen sulfide inhibits plasma renin activity. J Am Soc Nephrol 21(6):993\u20131002","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"3601_CR12","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/j.freeradbiomed.2011.02.016","volume":"50","author":"ZS Xu","year":"2011","unstructured":"Xu ZS, Wang XY, Xiao DM et al (2011) Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis. Free Radic Biol Med 50(10):1314\u20131323","journal-title":"Free Radic Biol Med"},{"key":"3601_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/jat\/bku114","volume":"39","author":"V Varlet","year":"2014","unstructured":"Varlet V, Giuliani N, Palmiere C et al (2014) Hydogen sulfide measurement by headspace-gas chromatography-mass spectrometry (HS-GC-MS): application to gaseous samples and gas dissolved in muscle. J Anal Toxicol 39:52\u201357","journal-title":"J Anal Toxicol"},{"key":"3601_CR14","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1021\/ac60357a008","volume":"47","author":"RR Moest","year":"1975","unstructured":"Moest RR (1975) Hydrogen sulfide determination by the methylene blue method. Anal Chem 47:1204\u20131205","journal-title":"Anal Chem"},{"key":"3601_CR15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1467-4866-4-28","volume":"4","author":"JA Tossell","year":"2003","unstructured":"Tossell JA (2003) Calculation of the visible-UV absorption spectra of hydrogen sulfide, bisulfide, polysulfides, and as and sb sulfides, in aqueous solution. Geochem Trans 4:28\u201333","journal-title":"Geochem Trans"},{"key":"3601_CR16","doi-asserted-by":"publisher","first-page":"214336","DOI":"10.1016\/j.ccr.2021.214336","volume":"453","author":"X Yang","year":"2022","unstructured":"Yang X, Zhang D, Ye Y, Zhao Y (2022) Recent advances in multifunctional fluorescent probes for viscosity and analytes. Coordin Chem Rev 453:214336","journal-title":"Coordin Chem Rev"},{"key":"3601_CR17","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1039\/D1CS00543J","volume":"51","author":"R Wu Xi, Wang","year":"2022","unstructured":"Wu Xi, Wang R, Kwon N et al (2022) Activatable fluorescent probes for in situ imaging of enzymes. Chem Soc Rev 51:450\u2013463","journal-title":"Chem Soc Rev"},{"key":"3601_CR18","doi-asserted-by":"publisher","first-page":"214232","DOI":"10.1016\/j.ccr.2021.214232","volume":"450","author":"JT Hou","year":"2022","unstructured":"Hou JT, Kwon N, Wang S et al (2022) Sulfur-based fluorescent probes for HOCl: mechanisms, design, and applications. Coordin Chem Rev 450:214232","journal-title":"Coordin Chem Rev"},{"key":"3601_CR19","doi-asserted-by":"publisher","first-page":"10078","DOI":"10.1021\/ja203661j","volume":"133","author":"AR Lippert","year":"2011","unstructured":"Lippert AR, New EJ, Chang CJ (2011) Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. J Am Chem Soc 133:10078\u201310080","journal-title":"J Am Chem Soc"},{"key":"3601_CR20","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1039\/c2cc30730h","volume":"48","author":"LA Montoya","year":"2012","unstructured":"Montoya LA, Pluth MD (2012) Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells. Chem Commun 48:4767\u20134769","journal-title":"Chem Commun"},{"key":"3601_CR21","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1039\/D3AY00375B","volume":"15","author":"C Xu","year":"2023","unstructured":"Xu C, Zhang YK, Sun H et al (2023) Development of a two-photon fluorescent probe for imaging hydrogen sulfide (H2S) in living cells and zebrafish. Anal Methods 15:1948\u20131952","journal-title":"Anal Methods"},{"key":"3601_CR22","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ncomms1506","volume":"2","author":"Y Qian","year":"2011","unstructured":"Qian Y, Karpus J, Kabil O et al (2011) Selective fluorescent probes for live-cell monitoring of sulphide. Nat Commun 2:495\u2013501","journal-title":"Nat Commun"},{"key":"3601_CR23","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1021\/ol3008183","volume":"14","author":"CR Liu","year":"2012","unstructured":"Liu CR, Peng B, Li S, Park CM, Whorton AR, Xia M (2012) Reaction based fluorescent probes for hydrogen sulfide. Org Lett 14:2184\u20132187","journal-title":"Org Lett"},{"issue":"45","key":"3601_CR24","doi-asserted-by":"publisher","first-page":"18003","DOI":"10.1021\/ja207851s","volume":"133","author":"K Kiyoshi Sasakura","year":"2011","unstructured":"Kiyoshi Sasakura K, Hanaoka N, Shibuya Y, Mikami Y, Kimura T, Komatsu T, Ueno T, Terai H, Kimura, Tetsuo Nagano (2011) Development of a highly selective fluorescence probe for Hydrogen Sulfide. J Am Chem Soc 133(45):18003\u201318005","journal-title":"J Am Chem Soc"},{"key":"3601_CR25","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.snb.2019.03.141","volume":"290","author":"T Fang","year":"2019","unstructured":"Fang T, Jiang XD, Sun C, Li Q (2019) BODIPY-based naked-eye fluorescent on-off probe with high selectivity for H2S based on thiolysis of dinitrophenyl ether. Sens Actuators B 290:551\u2013557","journal-title":"Sens Actuators B"},{"key":"3601_CR26","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/chem.201303757","volume":"20","author":"B Peng","year":"2014","unstructured":"Peng B, Chen W, Liu C et al (2014) Fluorescentprobes based on nucleophilic substitution-cyclization for hydrogen sulfidedetection and bioimaging. Chem Eur J 20:1010\u20131016","journal-title":"Chem Eur J"},{"key":"3601_CR27","doi-asserted-by":"publisher","first-page":"13456","DOI":"10.1039\/D3NJ01700A","volume":"47","author":"Y Chen","year":"2023","unstructured":"Chen Y, Xu QQ, Zhao WJ, Wang CY (2023) A mitochondria-targeting off\u2013on AIE probe with large Stokes shift for high-contrast H2S imaging in living cells. New J Chem 47:13456\u201313461","journal-title":"New J Chem"},{"key":"3601_CR28","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1007\/s10895-023-03179-2","volume":"33","author":"WS Zhang","year":"2023","unstructured":"Zhang WS, Xun Q, Xing WF, Xu F, Liu X (2023) A highly selective fluorescent probe for imaging hydrogen sulfide in living HeLa cells. J Fluoresc 33:1603\u20131608","journal-title":"J Fluoresc"},{"key":"3601_CR29","doi-asserted-by":"publisher","first-page":"9614","DOI":"10.1039\/C9NJ01643K","volume":"43","author":"M Qian","year":"2019","unstructured":"Qian M, Zhang LW, Wang JY (2019) A NIR fluorescent sensor for biothiols based on a dicyanoisophorone derivative with a large Stokes shift and high quantum yield. New J Chem 43:9614\u20139622","journal-title":"New J Chem"},{"key":"3601_CR30","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1007\/s10895-022-02964-9","volume":"32","author":"YY Wang","year":"2022","unstructured":"Wang YY, Yu XS, Li XJ et al (2022) A Rapid Near-Infrared fluorescent probe for Cysteine based on Isophorone and its application in B16 cell imaging. J Fluoresc 32:1661\u20131667","journal-title":"J Fluoresc"},{"key":"3601_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jphotochem.2018.10.030","volume":"370","author":"LW Zhang","year":"2019","unstructured":"Zhang LW, Qian M, Xia J et al (2019) A NIR fluorescent sensor with large Stokes shift for the real-time visualization of endogenous hydrogen peroxide in living cells. J Photochem Photobiol A 370:12\u201317","journal-title":"J Photochem Photobiol A"},{"key":"3601_CR32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10895-022-03040-y","volume":"33","author":"L Yan","year":"2023","unstructured":"Yan L, Zhou C, Li J et al (2023) A near-infrared fluorescent probe based on Dicyanisophorone for the detection of zinc ions (Zn2+) in Water and living cells. J Fluoresc 33:201\u2013207","journal-title":"J Fluoresc"},{"key":"3601_CR33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.3891\/acta.chem.scand.52-0490","volume":"52","author":"P Kolsaker","year":"1998","unstructured":"Kolsaker P, Arukwe J, Barcoczy J, Wilberg A, Fagerli AK (1998) Ring-Chain Tautomerism in 2-(2,2-Dicyano-1-methylethenyl)benzoic acid and related compounds. Acta Chem Scand 52:490\u2013498","journal-title":"Acta Chem Scand"},{"key":"3601_CR34","doi-asserted-by":"publisher","first-page":"15432","DOI":"10.1039\/D0NJ02913K","volume":"44","author":"Y Wang","year":"2020","unstructured":"Wang Y, Zhang WD, Ma T et al (2020) A new chloro-substituted dicyanoisophorone-based near-infrared fluorophore with a larger Stokes shift and its application for detecting cysteine in cells and in vivo. New J Chem 44:15432\u201315438","journal-title":"New J Chem"},{"issue":"16","key":"3601_CR35","doi-asserted-by":"publisher","first-page":"5334","DOI":"10.1021\/jacs.6b01705","volume":"138","author":"KZ Gu","year":"2016","unstructured":"Gu KZ, Xu YS, Li H et al (2016) Real-time tracking and in vivo visualization of \u03b2-galactosidase activity in colorectal tumor with a ratiometric nearinfrared fluorescent probe. J Am Chem Soc 138(16):5334\u20135340","journal-title":"J Am Chem Soc"}],"container-title":["Journal of Fluorescence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10895-024-03601-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10895-024-03601-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10895-024-03601-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T12:02:57Z","timestamp":1740830577000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10895-024-03601-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["3601"],"URL":"https:\/\/doi.org\/10.1007\/s10895-024-03601-3","relation":{},"ISSN":["1573-4994"],"issn-type":[{"value":"1573-4994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"29 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The participant has consented to the submission of this work to the journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}