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We interviewed 21 individuals (8 with and 4 without the mutation, and 9 un\u2010tested) in\u2010depth for 2 hours each. At\u2010risk individuals faced a difficult series of dilemmas of whether to: get pregnant and deliver, have fetal testing, have pre\u2010implantation genetic diagnosis, adopt, or have no children. These individuals weighed competing desires and concerns: their own desires vs. those of spouses vs. broader moral concerns (e.g., to end the disease; and\/or follow dictates against abortion) vs. perceptions of the interests of current or future offspring. Quandaries arose of how much and to whom to feel responsible. Some changed their perspectives over time (e.g., first \u201cgambling,\u201d then being more cautious). 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