{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:13:24Z","timestamp":1760242404100},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T00:00:00Z","timestamp":1214352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Detailed family history is a critical element of cancer risk assessment. The relative importance of pancreatic cancer (PC) in a close family member, particularly in hereditary breast\u2010ovarian syndrome (HBOS), is not clearly defined. We use a case\u2010control design to investigate the importance of a family history of PC to cancer risk assessment. Case and control families were identified from the University of Chicago Cancer Risk database (1994\u20132005). Pedigrees were analyzed for personal and familial clinical cancer data. Cases included all new subjects (probands) reporting a close relative (first or second degree) with PC. Controls included the probands enrolled in the database immediately prior to and subsequent to each case (i.e. two controls for each case). From 1,231 pedigrees, 103 PC were reported by the proband in 87 unique families. Many probands reported multiple or early\u2010onset PCs: one third (28\/87) of case families met criteria for a familial PC syndrome [\u22652 first\u2010degree relatives with PC (<jats:italic>n<\/jats:italic>\u2009=\u200910) or PC diagnosed \u226450 (<jats:italic>n<\/jats:italic>\u2009=\u200918)]. Of these families, the majority (75%) concurrently met criteria suggestive of hereditary breast\u2010ovarian syndrome (HBOS). Because of a family history consistent with HBOS, at least one individual from each of 29 case and 55 control families underwent genetic testing for <jats:italic>BRCA1\/2<\/jats:italic>. Among case families, 19 of 29 (66%) had a <jats:italic>BRCA1\/2<\/jats:italic> mutation compared with 16 of 55 (29%) controls. A significant association between family history of PC and a <jats:italic>BRCA1\/2<\/jats:italic> mutation was seen (OR 3.78, 1.32\u201310.9). This point estimate was strengthened but less precise in the non\u2010Ashkenazi Jewish subset of tested families (OR 6.03, 1.68\u201322.14). In a high\u2010risk population, a family history of PC, though infrequently reported, is nonetheless clinically meaningful. In risk assessment for HBOS, identifying a family history of PC should strongly raise the suspicion of an unrecognized <jats:italic>BRCA1\/2<\/jats:italic> mutation.<\/jats:p>","DOI":"10.1007\/s10897-008-9154-3","type":"journal-article","created":{"date-parts":[[2008,6,24]],"date-time":"2008-06-24T21:10:07Z","timestamp":1214341807000},"page":"365-372","source":"Crossref","is-referenced-by-count":4,"title":["Family History of Pancreatic Cancer in a High\u2010Risk Cancer Clinic: Implications for Risk Assessment"],"prefix":"10.1002","volume":"17","author":[{"given":"Michael J.","family":"Hall","sequence":"first","affiliation":[{"name":"Departments of Medicine and Epidemiology Columbia University College of Physicians and Surgeons, Mailman School of Public Health New York NY 10032 USA"},{"name":"New York Presbyterian Hospital New York NY 10032 USA"},{"name":"Division of Medical Oncology Columbia University Medical Center 161 Fort Washington Avenue, Room 9\u2010907 New York NY 10032 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Dignam","sequence":"additional","affiliation":[{"name":"Department of Health Studies University of Chicago Chicago IL 60637 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunmilayo I.","family":"Olopade","sequence":"additional","affiliation":[{"name":"Center for Clinical Cancer Genetics University of Chicago Chicago IL 60637 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.15.1310"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.05.121"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540360065034"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0783"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.00.133"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.017996"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079381"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91962-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1102"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3823"},{"key":"e_1_2_6_15_1","first-page":"409","article-title":"Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ\u2010line p16, BRCA1, and BRCA2 mutations","volume":"60","author":"Lal G.","year":"2000","journal-title":"Cancer Research"},{"key":"e_1_2_6_16_1","first-page":"1507","article-title":"Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review","volume":"27","author":"Lindor N. 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