{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:54:15Z","timestamp":1762001655096},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T00:00:00Z","timestamp":1215475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a family with an extensive history of colon cancer consistent with hereditary nonpolyposis colorectal cancer (HNPCC). A specific disease causing mutation was identified in affected individuals; p.W714X <jats:italic>MLH1<\/jats:italic> mutation. Given the very young age of onset of cancer in some affected family members, with the youngest affected individual being 19 years of age, genetic counseling was recommended to children as young as 9 years. Ethical issues arose when affected families requested genetic testing for their underage children. Here we describe and debate the value of offering molecular testing for this adult onset disorder to several children in this particular family. We also examine possible molecular causes for the very young age of onset in some family members.<\/jats:p>","DOI":"10.1007\/s10897-008-9161-4","type":"journal-article","created":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T18:16:14Z","timestamp":1215454574000},"page":"523-525","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Testing of Children at Risk for Adult Onset Conditions: When is Testing Indicated?"],"prefix":"10.1002","volume":"17","author":[{"given":"N.","family":"Lwiwski","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health and Department of Biochemistry and Medical Genetics University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health and Department of Biochemistry and Medical Genetics University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Mhanni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health and Department of Biochemistry and Medical Genetics University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.189"},{"key":"e_1_2_5_3_1","first-page":"1233","article-title":"Points to consider: Ethical, legal, and psychosocial implications of genetic testing in children and adolescents","volume":"57","author":"ASHG\/ACMG Board of Directors","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj073"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.83.4.283"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-005-4840-x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/983459"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOGC.0000013379.90587.ef"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31070"},{"issue":"3","key":"e_1_2_5_10_1","first-page":"605","article-title":"Genetic testing of children for adult\u2010onset diseases: Is testing in the child's best interests?","volume":"73","author":"Pelias M. 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