{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:54:45Z","timestamp":1766588085267},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T00:00:00Z","timestamp":1242864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The number of individuals receiving genetic counseling for hereditary breast and ovarian cancer syndrome has steadily risen. To triage patients for genetic counseling and to help reduce the amount of time needed by a genetic counselor in direct patient contact, many clinics have implemented the use of family history questionnaires. Although such questionnaires are widely used, scant literature exists evaluating their effectiveness. This article explores the extent to which family history questionnaires are being used in Ontario and addresses the utility of such questionnaires in one familial cancer clinic. By comparing the pedigrees created from questionnaires to those updated during genetic counseling, the accuracy and effectiveness of the questionnaires was explored. Of 121 families recruited into the study, 12% acquired changes to their pedigree that led to a revised probability estimate for having a BRCA1 or BRCA2 mutation and 5% acquired changes that altered their eligibility for genetic testing. No statistically significant difference existed between the eligibility for genetic testing prior to and post counseling. This suggests that family history questionnaires can be effective at obtaining a family history and accurately assessing eligibility for genetic testing. Based on the variables that were significantly associated with a change in probability estimate, we further present recommendations for improving the clarity of such questionnaires and therefore the ease of use by patients.<\/jats:p>","DOI":"10.1007\/s10897-009-9228-x","type":"journal-article","created":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T16:36:09Z","timestamp":1242837369000},"page":"366-378","source":"Crossref","is-referenced-by-count":19,"title":["The Effectiveness of Family History Questionnaires in Cancer Genetic Counseling"],"prefix":"10.1002","volume":"18","author":[{"given":"Susan","family":"Randall Armel","sequence":"first","affiliation":[{"name":"The Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital 610 University Ave, M704 Toronto ON M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanna","family":"McCuaig","sequence":"additional","affiliation":[{"name":"The Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital 610 University Ave, M704 Toronto ON M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Finch","sequence":"additional","affiliation":[{"name":"The Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital 610 University Ave, M704 Toronto ON M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Demsky","sequence":"additional","affiliation":[{"name":"The Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital 610 University Ave, M704 Toronto ON M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Panzarella","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Princess Margaret Hospital 610 University Ave Toronto ON M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Murphy","sequence":"additional","affiliation":[{"name":"The Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital 610 University Ave, M704 Toronto ON M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Rosen","sequence":"additional","affiliation":[{"name":"The Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital 610 University Ave, M704 Toronto ON M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.05.121"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.15.1310"},{"key":"e_1_2_6_5_1","first-page":"A333","article-title":"A self\u2010administered family history questionnaire (FHQ) utilized in an outpatient setting to assess cancer risk","volume":"59","author":"Brener D.","year":"1996","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2648.2001.01866.x"},{"key":"e_1_2_6_7_1","volume-title":"Cyrillic 3","author":"FamyGenetix Ltd.","year":"2001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91578-4"},{"key":"e_1_2_6_9_1","first-page":"7076","article-title":"Women's need for information before attending genetic counselling for familial breast or ovarian cancer: a questionnaire, interview, and observational study","volume":"281","author":"Hallowell N.","year":"1997","journal-title":"BMJ(Clinical Research Ed)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088759"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201256"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"e_1_2_6_13_1","volume-title":"Canadian Cancer Statistics 2007","author":"NCIC","year":"2007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/318787"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj465"},{"issue":"5","key":"e_1_2_6_16_1","first-page":"467","article-title":"The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations","volume":"10","author":"Satagopan J. M.","year":"2001","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03300-5"},{"issue":"3","key":"e_1_2_6_18_1","first-page":"496","article-title":"Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: results from three U.S. population\u2010based case\u2010control studies of ovarian cancer","volume":"60","author":"Whittemore A. S.","year":"1997","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/378789a0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(02)00593-7"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10897-009-9228-x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s10897-009-9228-x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10897-009-9228-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:24:44Z","timestamp":1694751884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10897-009-9228-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,21]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1007\/s10897-009-9228-x"],"URL":"https:\/\/doi.org\/10.1007\/s10897-009-9228-x","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,21]]}}}