{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:52:00Z","timestamp":1720659120560},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five to 10% of all cases of breast and ovarian cancer are attributed to a heritable genetic predisposition. Transmission of <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> mutations is equally likely through maternal or paternal lineage; however, fewer referrals to cancer genetics clinics appear to be made for a paternal, than maternal, family history of breast and\/or ovarian cancer. To examine this potential bias, a retrospective review of 315 patient and family charts was conducted by one familial cancer clinic in Toronto, Canada. Referral letters, risk estimates, and family histories were analyzed to identify significant differences between patients referred with maternal and paternal family histories. It was determined that patients are approximately five times more likely to be referred with a maternal family history of breast and\/or ovarian cancer as compared to those with a paternal family history (<jats:italic>p<\/jats:italic>\u2009=\u2009&lt;.0001). Individuals with a paternal family history were found to have a different, and higher, pattern of risk estimates (<jats:italic>p<\/jats:italic>\u2009=\u2009.00064). No significant difference was seen between the type of referrals sent by general practitioners, oncologists, and gynecologists. Recommendations to increase the awareness of paternal family history in assessing cancer risk are provided.<\/jats:p>","DOI":"10.1007\/s10897-011-9368-7","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T17:23:57Z","timestamp":1303147437000},"page":"442-449","source":"Crossref","is-referenced-by-count":4,"title":["Breast and Ovarian Cancer: The Forgotten Paternal Contribution"],"prefix":"10.1002","volume":"20","author":[{"given":"Jeanna M.","family":"McCuaig","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology Princess Margaret Hospital \u2010 University Health Network Toronto Canada"},{"name":"Department of Molecular Genetics University of Toronto Toronto Canada"},{"name":"Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital M\u2010704 610 University Avenue Toronto Ontario M5G 2M9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia M. T.","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research Montreal Canada"},{"name":"Department of Oncology McGill University Montreal Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Shuman","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics University of Toronto Toronto Canada"},{"name":"Division of Clinical and Metabolic Genetics The Hospital for Sick Children Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chitayat","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics University of Toronto Toronto Canada"},{"name":"Division of Clinical and Metabolic Genetics The Hospital for Sick Children Toronto Canada"},{"name":"Department of Molecular Genetics Mount Sinai Hospital Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Joan","family":"Murphy","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Princess Margaret Hospital \u2010 University Health Network Toronto Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Rosen","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Princess Margaret Hospital \u2010 University Health Network Toronto Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Randall","family":"Armel","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Princess Margaret Hospital \u2010 University Health Network Toronto Canada"},{"name":"Department of Molecular Genetics University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-009-9228-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000121400"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S026646230505049X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2007.0036"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32643"},{"key":"e_1_2_6_7_1","unstructured":"Canadian Cancer Society's Steering Committee:Canadian Cancer Statistics 2010. Toronto: Canadian Cancer Society 2010. April2010 ISSN 0835\u20132976."},{"issue":"12","key":"e_1_2_6_8_1","first-page":"1691","article-title":"Hereditary breast and ovarian cancers","volume":"54","author":"Carroll J. C.","year":"2008","journal-title":"Canadian Family Physician"},{"issue":"12","key":"e_1_2_6_9_1","first-page":"e92","article-title":"Genetic education for primary care providers: improving attitudes, knowledge, and confidence","volume":"55","author":"Carroll J. C.","year":"2009","journal-title":"Canadian Family Physician"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6920-10-42"},{"key":"e_1_2_6_11_1","unstructured":"Centre for Disease Control and Prevention. (2010).Hereditary breast and ovarian cancer: What causes breast cancer. 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