{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:00:06Z","timestamp":1760043606305},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Technological advances and information\u2010seeking consumers have pushed forward the movement of direct\u2010to\u2010consumer (DTC) genetic testing. Just like with other types of testing, there are potential risks, benefits and limitations. A major limitation of DTC testing is the incomplete view it provides regarding lifetime risk for common, complex diseases, since most tests only analyze 1\u20132 single nucleotide polymorphisms (SNPs) and do not include evaluation of medical or family histories, which is necessary to risk assessment. Further, it is not currently well\u2010established whether personal genomic testing results will lead toward improved health behaviors, adverse psychological effects or potential overuse of the health care system. To display these and other issues, we present an in\u2010depth case study of an individual who ordered DTC genetic testing and subsequently sought genetic counseling. This case presents a unique learning experience for the field of genomic counseling, as the patient did not fit the typical assumptions regarding \u2018early adopters\u2019 of DTC testing. It also allowed the genetics health care providers involved in the case to identify gaps in current genetic counseling practice that need to be filled and approaches to employ for successful delivery of genomic counseling. Based on our experience, we developed practical recommendations for genomic counseling, which include novel approaches to case preparation, use of electronic tools during the counseling session, and focusing on education as the major component of the genomic counseling session, in order to provide patients with the knowledge necessary to independently interpret and understand large amounts of genomic testing information provided to them.<\/jats:p>","DOI":"10.1007\/s10897-012-9489-7","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T22:40:45Z","timestamp":1328049645000},"page":"402-412","source":"Crossref","is-referenced-by-count":23,"title":["Direct\u2010to\u2010Consumer Personal Genomic Testing: A Case Study and Practical Recommendations for \u201cGenomic Counseling\u201d"],"prefix":"10.1002","volume":"21","author":[{"given":"Amy C.","family":"Sturm","sequence":"first","affiliation":[{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University Medical Center Columbus OH USA"},{"name":"Center for Personalized Health Care The Ohio State University Medical Center Columbus OH USA"},{"name":"Division of Human Genetics, Center for Personalized Health Care The Ohio State University Medical Center 2001 Polaris Parkway Columbus OH 43240 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandamurugu","family":"Manickam","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University Medical Center Columbus OH USA"},{"name":"Center for Personalized Health Care The Ohio State University Medical Center Columbus OH USA"},{"name":"Center for Molecular and Human Genetics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.649"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31819d30f2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011893"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-010-0023-z"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090198105278825"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0013947"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31815a9dcc"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1294"},{"key":"e_1_2_5_10_1","unstructured":"DTC Genetic Testing Companies Compiled by the Genetics and Public Policy Center. 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