{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:38:32Z","timestamp":1786786712379,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Noninvasive prenatal testing (NIPT) allows for highly sensitive detection of Down syndrome early in pregnancy with no risk of miscarriage, therefore potentially increasing the number of pregnancies identified with Down syndrome. This study assesses how mothers of children with Down syndrome perceive NIPT, especially the impact they think it will have on their families and other families with children who have Down syndrome. Seventy\u2010three self\u2010reported mothers of children with Down syndrome responded to an anonymous online survey emailed to, and posted on, message boards of various Down syndrome support groups and networks. Data analysis included chi\u2010square tests and thematic analysis. Fifty\u2010nine percent of respondents indicated they would use NIPT in the future; respondents who had not used prenatal testing in the past were significantly less likely to report interest in using NIPT in the future than those who had prenatal testing previously (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Many respondents felt NIPT could lead to increased terminations (88 %), increased social stigma (57 %), and decreased availability of services for individuals with Down syndrome (64 %). However, only 16 % believed availability of new noninvasive tests would be the most important factor in determining the number of pregnancies with Down syndrome terminated in the future. Additionally, 48 % believed health care providers give biased or incorrect information about Down syndrome at the time of diagnosis, and 24 % felt this incorrect information leads to terminations of pregnancies affected with Down syndrome. Results suggest although mothers of children with Down syndrome believe new noninvasive testing will lead to an increase in termination of pregnancies with Down syndrome, they do not think it is the MOST important factor. They also highlight the need to provide a diagnosis of Down syndrome in a balanced and objective manner.<\/jats:p>","DOI":"10.1007\/s10897-014-9694-7","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T22:12:53Z","timestamp":1391206373000},"page":"805-813","source":"Crossref","is-referenced-by-count":58,"title":["Attitudes of Mothers of Children with Down Syndrome Towards Noninvasive Prenatal Testing"],"prefix":"10.1002","volume":"23","author":[{"given":"Gregory","family":"Kellogg","sequence":"first","affiliation":[{"name":"Department of Genetics Stanford University School of Medicine 300 Pasteur Drive, H315 Stanford CA 94305\u20105208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Slattery","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Medical Genetics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louanne","family":"Hudgins","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Medical Genetics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Ormond","sequence":"additional","affiliation":[{"name":"Department of Genetics Stanford University School of Medicine 300 Pasteur Drive, H315 Stanford CA 94305\u20105208 USA"},{"name":"Stanford Center for Biomedical Ethics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000423819.85283.f4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2919"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11083"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31824fb482"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02646830500129214"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810641105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.203"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-012-9564-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808319105"},{"key":"e_1_2_7_12_1","first-page":"671","article-title":"Genetic counselors and prenatal testing: where is the discussion about disability?","volume":"19","author":"Farrelly E.","year":"2010","journal-title":"Journal of Genetic Counseling"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/469289a"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.29"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-011-9416-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-009-9248-6"},{"key":"e_1_2_7_17_1","unstructured":"Hurford E. 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Hudgins L. &Taylor J.(2013).The decision to continue a pregnancy affected by Down syndrome: timing of decision and satisfaction of receiving a prenatal diagnosis.Journal of Genetic Counseling.doi:10.1007\/s10897\u2010013\u20109590\u20106."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35238"},{"key":"e_1_2_7_19_1","volume-title":"Non\u2010invasive prenatal diagnosis: A study of public attitudes","author":"Kelly S.E.","year":"2011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02174-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34054"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2434"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182368a0e"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.73"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980806)78:5<433::AID-AJMG8>3.0.CO;2-M"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/00224669020360010501"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-011-9375-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.166017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2888"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3886"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10897-014-9694-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T22:59:02Z","timestamp":1694818742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10897-014-9694-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1007\/s10897-014-9694-7"],"URL":"https:\/\/doi.org\/10.1007\/s10897-014-9694-7","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}