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However, whilst revealing the future presence of the disease, testing may have an adverse psychological impact given that the disease is progressive, incurable and ultimately fatal. This review seeks to systematically explore the psychological impact of genetic testing for individuals undergoing pre\u2010symptomatic mutation analysis. Three databases (Medline, PsycInfo and Scopus) were interrogated for studies utilising standardised measures to assess psychological impact following predictive genetic testing for HD. From 100 papers initially identified, eight articles were eligible for inclusion. Psychological impact of predictive genetic testing was not found to be associated with test result. No detrimental effect of predictive genetic testing on non\u2010carriers was found, although the process was not found to be psychologically neutral. Fluctuation in levels of distress was found over time for carriers and non\u2010carriers alike. Methodological weaknesses of published literature were identified, notably the needs of individuals not requesting genetic testing, as well as inadequate support for individuals registering elevated distress and declining post\u2010test follow\u2010up. Further assessment of these vulnerable individuals is warranted to establish the extent and type of future psychological support.<\/jats:p>","DOI":"10.1007\/s10897-014-9755-y","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T22:48:20Z","timestamp":1411080500000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["The Psychological Impact of Predictive Genetic Testing for Huntington\u2032s Disease: A Systematic Review of the Literature"],"prefix":"10.1002","volume":"24","author":[{"given":"S","family":"Crozier","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology University of Leicester 104 Regent Road Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology University of Leicester 104 Regent Road Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dale","sequence":"additional","affiliation":[{"name":"Adult Mental Health Psychology Leicestershire Partnership NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"A292","article-title":"Predictive testing for Huntington disease (HD): Differences in uptake and characteristics of linked marker and direct test cohorts","volume":"57","author":"Adam S.","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00157.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2013.802355"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0037562"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.171.1.78"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200532"},{"key":"e_1_2_10_9_1","volume-title":"SF\u201036: Fragebogen zum Gesundheitszustand.","author":"Bullinger M.","year":"1998"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.16.1.36"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90722-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2010-000048"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.9.737"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484792"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700048017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.5.382"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199809000-00005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30158"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-3991(98)00086-X"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320590117"},{"key":"e_1_2_10_21_1","volume-title":"Huntington's Disease: A Disorder of Families.","author":"Folstein S. 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