{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:05:09Z","timestamp":1765667109468},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Single nucleotide polymorphisms (SNPs) have the potential to improve personalized medicine in breast cancer care. As new SNPs are discovered, further enhancing risk classification, SNP testing may serve to complement family history and phenotypic risk factors when assessed in a clinical setting. SNP analysis is particularly relevant to high\u2010risk women who may seek out such information to guide their decision\u2010making around risk\u2010reduction. However, little is known about how high\u2010risk women may respond to SNP testing with regard to clinical decision\u2010making. We examined high\u2010risk women's interest in SNP testing for breast cancer risk through an online survey of hypothetical testing scenarios. Women stated their preferences for sharing test results and selected the most likely follow\u2010up action they would pursue in each of the test result scenarios (above average and below average risk for breast cancer). Four hundred seventy\u2010eight women participated. Most women (89 %) did not know what a SNP was prior to the study. Once SNP testing was described, 75 % were interested in SNP testing. Participants stated an interest in lifestyle interventions for risk\u2010reduction and wanted to discuss their testing results with their doctor or a genetic counselor. Women are interested in SNP testing and are prepared to make lifestyle changes based on testing results. Women's preference for discussing testing results with a healthcare provider aligns with the current trend towards SNP testing in a clinical setting.<\/jats:p>","DOI":"10.1007\/s10897-014-9803-7","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T05:41:27Z","timestamp":1418794887000},"page":"744-751","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Personalized Medicine Through SNP Testing for Breast Cancer Risk: Clinical Implementation"],"prefix":"10.1002","volume":"24","author":[{"given":"Rebecca","family":"Howe","sequence":"first","affiliation":[{"name":"Frank H. Netter MD School of Medicine Quinnipiac University North Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talya","family":"Miron\u2010Shatz","sequence":"additional","affiliation":[{"name":"Center for Medical Decision Making Ono Academic College Kiryat Ono Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaniv","family":"Hanoch","sequence":"additional","affiliation":[{"name":"Department of Psychology Plymouth University Plymouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra B.","family":"Omer","sequence":"additional","affiliation":[{"name":"School of Medicine University of Massachusetts Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"O'Donoghue","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Illinois at Chicago Chicago IL USA"},{"name":"Department of Surgery University of California at San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa M.","family":"Ozanne","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California at San Francisco San Francisco CA USA"},{"name":"The Dartmouth Institute for Health Policy and Clinical Practice Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1316367"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1907"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e3182610e38"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011893"},{"issue":"3","key":"e_1_2_6_6_1","first-page":"227","article-title":"Importance of psychological variables in understanding risk perceptions and breast cancer screening of African American women","volume":"3","author":"Bowen D.","year":"1997","journal-title":"Women's Health (Hillsdale, N.J.)"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.747"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr265"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13187-010-0097-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01807037"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05887"},{"key":"e_1_2_6_12_1","first-page":"CD001865","article-title":"Personalised risk communication for informed decision making about taking screening tests","volume":"2","author":"Edwards A. 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