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Our aim was to compare effects of CHOICES, a Web\u2010based multimedia education program on implementing informed reproductive plans, and usual care education (e\u2010Book) on reproductive knowledge, intention, and behavior over 24 months. We randomized 234 participants with SCD (<jats:italic>n<\/jats:italic>\u2009=\u2009138) or SCT (<jats:italic>n<\/jats:italic>\u2009=\u200996) (age 18\u201335 years, 35 % male, 94 % African American) to CHOICES and e\u2010Book groups. Participants completed a sickle cell\u2010specific reproductive measure before and four times after the intervention (6, 12, 18 and 24 months). Compared to the e\u2010Book group the CHOICES group had significantly more improvement in knowledge over time (<jats:italic>p<\/jats:italic>\u2009=\u2009.004) but not intention (<jats:italic>p<\/jats:italic>\u2009=\u2009.18) or behavior (<jats:italic>p<\/jats:italic>\u2009=\u2009.69). At baseline, 114 (48.7 %) participants reported having partners who would <jats:italic>not<\/jats:italic> put the couple at risk for their children inheriting SCD. Of the 116 (49.6 %) <jats:italic>at<\/jats:italic>\u2010<jats:italic>risk<\/jats:italic> participants, a higher poroportion of those who were in the CHOICES group chose partners that reduced their risk by the last visit than the e\u2010Book group (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). Study findings provide important insights for designing a national trial of the CHOICES intervention focusing on subjects whose partner status puts them at risk for having a child with SCD.<\/jats:p>","DOI":"10.1007\/s10897-015-9874-0","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:50:05Z","timestamp":1440636605000},"page":"325-336","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Reproductive Health CHOICES for Young Adults with Sickle Cell Disease or Trait: Randomized Controlled Trial Outcomes over Two Years"],"prefix":"10.1002","volume":"25","author":[{"given":"Agatha M.","family":"Gallo","sequence":"first","affiliation":[{"name":"Department of Women, Family and Children Health Science, College of Nursing University of Illinois at Chicago 845 S. 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Lurie Children's Hospital of Chicago Chicago IL USA"},{"name":"Northwestern University\u2010Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)31113-5"},{"key":"e_1_2_7_3_1","first-page":"46","volume-title":"Understanding attitudes and predicting social behavior","author":"Ajzen I.","year":"1980"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0275"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-011-9395-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/0264683021000060057"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/109019819602300411"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2011.010132"},{"key":"e_1_2_7_9_1","unstructured":"Centers for Disease Control and Prevention National Center on Birth Defects and Developmental Disabilities Division of Blood Disorders(2015).Sickle cell trait toolkit.Retrieved fromhttp:\/\/www.cdc.gov\/ncbddd\/traits.html."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.6.4.330"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2014.959922"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/515S16a"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2011.03.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2008.07.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0193945910371482"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1054773813479377"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24557"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","unstructured":"Hershberger P. 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