{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T20:57:55Z","timestamp":1782593875391,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is the second article of a two part series about utilizing the life course perspective (LCP) in genetic counseling. Secondary data analysis was conducted on a grounded theory, longitudinal study which provided a wide focus on living with hereditary breast and ovarian cancer (<jats:italic>HBOC<\/jats:italic>) risk. The aim of this analysis was to explore the longitudinal data for both the temporal and social context of living with BRCA mutation genetic test results. Sixteen women from two previous studies were interviewed on multiple occasions over an 8 year time period. The LCP was used to direct a thematic analysis of the data. Families experience the consequences of knowing they carry a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> gene mutation long after the initial diagnosis. These women's experiences across time reflect the concepts of the LCP and show how life is changed when families know they live with a genetic vulnerability to an adult\u2010onset and potentially life\u2010threatening disease. Different emphases on concepts from the LCP were evident across the different age groups. For example, the group of 40\u201350 year old women emphasized the concept of <jats:italic>linked lives<\/jats:italic>, those in their 30's focused on <jats:italic>human agency<\/jats:italic> and women in their 20's were more focused on <jats:italic>timing of events<\/jats:italic>. This study helps give direction to healthcare providers counseling women living with a <jats:italic>BRCA<\/jats:italic> mutation.<\/jats:p>","DOI":"10.1007\/s10897-015-9877-x","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:58:37Z","timestamp":1441069117000},"page":"49-61","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Living With Genetic Vulnerability: a Life Course Perspective"],"prefix":"10.1002","volume":"25","author":[{"given":"Rebekah J.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Department of Women, Children &amp; Family Nursing Rush University College of Nursing 2624 Newcastle Dr. Carrollton TX 75007 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Innella","sequence":"additional","affiliation":[{"name":"Department of Women, Children &amp; Family Nursing Rush University College of Nursing 2624 Newcastle Dr. Carrollton TX 75007 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn T.","family":"Bounds","sequence":"additional","affiliation":[{"name":"Department of Women, Children &amp; Family Nursing Rush University College of Nursing 2624 Newcastle Dr. Carrollton TX 75007 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026450103225"},{"key":"e_1_2_10_4_1","volume-title":"Transforming qualitative information: Thematic analysis and code development","author":"Boyatzis R. 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Eeles R. &Ormondroyd E.(2013).Reproductive decision\u2010making in young female carriers of a BRCA mutation.Human Reproduction. doi:10.1093\/humrep\/des441.","DOI":"10.1093\/humrep\/des441"},{"key":"e_1_2_10_11_1","first-page":"1","volume-title":"The craft of life course research","author":"Elder G. H.","year":"2009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605606"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.417"},{"issue":"6","key":"e_1_2_10_14_1","article-title":"Modifiers of Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: Systematic Review and Meta\u2010Analysis","volume":"106","author":"Friebel T.M.","year":"2014","journal-title":"Journal of the National Cancer Insitutet"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0991"},{"key":"e_1_2_10_16_1","unstructured":"Grubs R. E. Parker L. S. &Hamilton R. 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