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Komen for the Cure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Expanded genetic testing of BRCA mutations has led to identification of more reproductive\u2010aged women who test positive for the mutation which might impact attitudes and decisions about relationships, childbearing and the use of preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND). A cross\u2010sectional survey was administered to 1081 self\u2010reported BRCA carriers to investigate how knowledge of BRCA status influences these issues. The mean age at BRCA test disclosure was 44 years and 36 % reported a personal history of cancer. Of 163 women who were unpartnered, 21.5 % felt more pressure to get married. Of 284 women whose families were not complete, 41 % reported that carrier status impacted their decision to have biological children. Women with a history of cancer were more likely to report that knowledge of BRCA+ status impacted their decision to have a child (OR 1.8, 95 % CI 1\u20133.2). Fifty\u2010nine percent thought PGD should be offered to mutation carriers and 55.5 % thought PND should be offered. In conclusion, knowledge of BRCA status impacts attitudes regarding relationships and childbearing, and most carriers believe that PGD and PND should be offered to other carriers. This study suggests that BRCA carriers desire and would benefit from reproductive counseling after test disclosure.<\/jats:p>","DOI":"10.1007\/s10897-016-0035-x","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T23:16:06Z","timestamp":1477610166000},"page":"594-603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Reproductive Decision\u2010Making in Women with BRCA1\/2 Mutations"],"prefix":"10.1002","volume":"26","author":[{"given":"Jessica L.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pennsylvania Philadelphia PA USA"},{"name":"Center for Fertility and Reproductive Medicine Cedars\u2010Sinai Medical Center 8635 W. 3rd Street, Suite 160W Los Angeles CA 90048 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren N. C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pennsylvania Philadelphia PA USA"},{"name":"Reproductive Endocrinology Associates of Charlotte Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary D.","family":"Sammel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pennsylvania Philadelphia PA USA"},{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"DiGiovanni","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"},{"name":"Basser Center for BRCA University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Voong","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"},{"name":"Basser Center for BRCA University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"},{"name":"Basser Center for BRCA University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisa R.","family":"Gracia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a106d4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10102"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"89","article-title":"Women's interest in genetic testing for breast cancer risk: the influence of sociodemographics and knowledge","volume":"11","author":"Bottorff J. 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