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This study aimed to examine quality of life constructs among adults with NF1 in Brazil. It is an exploratory, descriptive and cross\u2010sectional study consisting of two stages, involving thirteen adult patients with NF1. The first stage was developed using a quantitative methodology, namely the WHOQOL\u2010100 questionnaire; responses for the 13 patients were compared to a matched control group. The second stage comprised clinical\u2010qualitative research whereby participants took part in a semi\u2010structured interview; these data were analyzed using the categorical thematic analysis technique. There were no statistically significant differences in the questionnaire domains between the NF1 patients and the control subjects. Eighteen main themes were extracted from the interviews, showing interference of the NF1 visibility principally in psychological aspects and social relationships. Patients mentioned curiosity about NF1 and confusion about the distinctions between NF1 and contagious diseases, which lead to prejudice. They were concerned about the future and how the disease would develop in themselves and their offspring, and emphasized difficulties acquiring proper healthcare. These findings may help in planning healthcare for Brazilian NF1 patients and improving their quality of life.<\/jats:p>","DOI":"10.1007\/s10897-016-9939-8","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T02:50:34Z","timestamp":1457146234000},"page":"1063-1074","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Quality of Life in Adults with Neurofibromatosis 1 in Brazil"],"prefix":"10.1002","volume":"25","author":[{"given":"Nat\u00e1lia Parenti","family":"Bicudo","sequence":"first","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldu\u00edno Ferreira","family":"de Menezes Neto","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucimar Retto","family":"da Silva de Av\u00f3","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Maria Ramos","family":"Germano","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Gusm\u00e3o","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Carlos S\u00e3o Paulo Brazil"},{"name":"Departamento de Medicina Rod. 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