{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:29:34Z","timestamp":1777030174839,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pre\u2010implantation genetic diagnosis (PGD) has changed the landscape of clinical genetics by helping families reduce the transmission of monogenic disorders. However, given the high prevalence of embryonic aneuploidy, particularly in patients of advanced reproductive age, unaffected embryos remain at high risk of implantation failure or pregnancy loss due to aneuploidy. 24\u2010chromosome aneuploidy screening has become widely utilized in routine in vitro fertilization (IVF) to pre\u2010select embryos with greater pregnancy potential, but concurrent 24\u2010chromosome aneuploidy screening has not become standard practice in embryos biopsied for PGD. We performed a retrospective cohort study of patients who underwent PGD with or without 24\u2010chromosome aneuploidy screening to explore the value of concurrent screening. Among the PGD + aneuploidy\u2010screened group (<jats:italic>n<\/jats:italic> = 355 blastocysts), only 25.6 % of embryos were <jats:italic>both<\/jats:italic> Single Gene Disorder (SGD)\u2010negative (or carriers) and euploid; thus the majority of embryos were ineligible for transfer due to the high prevalence of aneuploidy. Despite a young mean age (32.4 \u00b1 5.9y), 49.9 % of Blastocysts were aneuploid. The majority of patients (53.2 %) had \u22651 blastocyst that was Single Gene Disorder (SGD)\u2010unaffected <jats:italic>but<\/jats:italic> aneuploid; without screening, these unaffected but aneuploid embryos would likely have been transferred resulting in implantation failure, pregnancy loss, or a pregnancy affected by chromosomal aneuploidy. Despite the transfer of nearly half the number of embryos in the aneuploidy\u2010screened group (1.1 \u00b1 0.3 vs. 1.9 \u00b1 0.6, <jats:italic>p<\/jats:italic> &lt; 0.0001), the implantation rate was higher (75 % vs. 53.3 %) and miscarriage rate lower (20 % vs. 40 %) (although not statistically significant). 24\u2010chromosome aneuploidy screening when performed concurrently with PGD provides valuable information for embryo selection, and notably improves single embryo transfer rates.<\/jats:p>","DOI":"10.1007\/s10897-016-9975-4","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T04:05:05Z","timestamp":1465445105000},"page":"1327-1337","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Preimplantation Genetic Diagnosis (PGD) for Monogenic Disorders: the Value of Concurrent Aneuploidy Screening"],"prefix":"10.1002","volume":"25","author":[{"given":"Kara N.","family":"Goldman","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility New York University Langone Medical Center New York NY 10016 USA"},{"name":"New York University Fertility Center 660 First Avenue, Fifth Floor New York NY 10016 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taraneh","family":"Nazem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility New York University Langone Medical Center New York NY 10016 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Berkeley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility New York University Langone Medical Center New York NY 10016 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Palter","sequence":"additional","affiliation":[{"name":"Gold Coast IVF 246 Crossways Park Drive West Woodbury NY 11797 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie A.","family":"Grifo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility New York University Langone Medical Center New York NY 10016 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.04.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000451757.51964.98"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.11.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal069"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.02.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12025"},{"key":"e_1_2_10_8_1","unstructured":"Fertility Sterility Journal Club Live (TM)(2015)Platform Event.https:\/\/youtu.be\/AuIkdBzmTTc.YouTube. 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