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The aim was to observe the decision\u2010making process of at\u2010risk individuals and explore their experiences following the decision as well as the impacts of positive and negative mutation results. Data were collected using two standardized questionnaires as well as via a semi\u2010standardized telephone interview one year after the initial counseling session. Seventy\u2010two individuals participated in at least one of the three phases of the survey, including 31 individuals in the telephone interview. Sociodemographic data were in accordance with previous reports. The process of predictive testing was generally perceived in a positive manner, with almost all interviewees reporting a balanced emotional state one year after initial counseling, regardless of the decision for or against the test. The most important reasons named in favor of or against testing were assembled as well as different aspects regarding the satisfaction with the reached decision. In line with and expanding previous observations on gender\u2010related differences in decision\u2010making, our results suggest that gender\u2010related aspects should be more strongly taken into account in genetic counseling during the predictive testing and counseling processes.<\/jats:p>","DOI":"10.1007\/s10897-017-0085-8","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:18:42Z","timestamp":1490919522000},"page":"1029-1040","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prospective Evaluation of Predictive DNA Testing for Huntington's Disease in a Large German Center"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-6021","authenticated-orcid":false,"given":"Ayseg\u00fcl","family":"Ibisler","sequence":"first","affiliation":[{"name":"Department of Human Genetics, Huntington Center NRW Ruhr\u2010University Bochum Universit\u00e4tsstra\u00dfe 150 Bochum 44801 Germany"},{"name":"Center for Rare Diseases Ruhr (CeSER) Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ocklenburg","sequence":"additional","affiliation":[{"name":"Department of Biopsychology, Institute of Cognitive Neuroscience Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Stemmler","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Huntington Center NRW Ruhr\u2010University Bochum Universit\u00e4tsstra\u00dfe 150 Bochum 44801 Germany"},{"name":"Center for Rare Diseases Ruhr (CeSER) Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Arning","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Huntington Center NRW Ruhr\u2010University Bochum Universit\u00e4tsstra\u00dfe 150 Bochum 44801 Germany"},{"name":"Center for Rare Diseases Ruhr (CeSER) Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg T.","family":"Epplen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Huntington Center NRW Ruhr\u2010University Bochum Universit\u00e4tsstra\u00dfe 150 Bochum 44801 Germany"},{"name":"Center for Rare Diseases Ruhr (CeSER) Bochum Germany"},{"name":"Faculty of Health University Witten\/Herdecke Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Saft","sequence":"additional","affiliation":[{"name":"Center for Rare Diseases Ruhr (CeSER) Bochum Germany"},{"name":"Department of Neurology, St. Josef Hospital, Huntington Center NRW Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hoffjan","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Huntington Center NRW Ruhr\u2010University Bochum Universit\u00e4tsstra\u00dfe 150 Bochum 44801 Germany"},{"name":"Center for Rare Diseases Ruhr (CeSER) Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-1057-y"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-150140"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2175"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2004.8.114"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.12.001"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31079"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200781"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12439"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","unstructured":"Gong P. 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