{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:49:56Z","timestamp":1740124196790,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To describe factors associated with preimplantation genetic diagnosis (PGD) decisions among Jewish Israeli <jats:italic>BRCA1\/2<\/jats:italic> carriers or spouses of a male carrier, we contacted all women who initiated PGD consultation for embryonic <jats:italic>BRCA1\/2<\/jats:italic> mutation detection at Sheba Medical Center, prior to March 2014. Applying a qualitative approach, we asked women to elaborate on the factors they considered in either opting for PGD or discontinuing the screening procedure. Participants were 18 Jewish Israeli women; 14 were carriers of one of the Ashkenazi founder mutations in <jats:italic>BRCA1\/2<\/jats:italic>, and four were spouses of male mutation carriers, who underwent at least one cycle of PGD. Prior to seeking PGD, ten of the women had no children. At the time of the interview, all but three had at least one child. Three factors emerged as key motivators for PGD: having witnessed the disease in a close relative (<jats:italic>n<\/jats:italic> = 12); prior IVF treatment for infertility (<jats:italic>n<\/jats:italic> = 12); and having pre\u2010existing frozen embryos (<jats:italic>n<\/jats:italic> = 6). Ten women withdrew from the PGD process due to clinical, logistical, and financial reasons. In conclusion, most women decided to withdraw from PGD instead of continuing until a successful conception was achieved. Those who opted for PGD attributed their discontinuation of further screening to the emotional burden that is greatly intensified by practical difficulties.<\/jats:p>","DOI":"10.1007\/s10897-017-0087-6","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T20:08:00Z","timestamp":1488830880000},"page":"1070-1079","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Performing and Declining PGD: Accounts of Jewish Israeli Women Who Carry a <i>BRCA1\/2<\/i> Mutation or Partners of Male Mutation Carriers"],"prefix":"10.1002","volume":"26","author":[{"given":"Efrat","family":"Dagan","sequence":"first","affiliation":[{"name":"Department of Nursing University of Haifa Haifa PO Box 3498838 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphna","family":"Birenbaum\u2010Carmeli","sequence":"additional","affiliation":[{"name":"Department of Nursing University of Haifa Haifa PO Box 3498838 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitan","family":"Friedman","sequence":"additional","affiliation":[{"name":"The Susanne\u2010Levy Gertner Oncogenetics Unit Sheba Medical Center Tel Aviv PO Box 52621 Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel\u2010Aviv PO Box 39040 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baruch","family":"Feldman","sequence":"additional","affiliation":[{"name":"Sheba Medical Center The Danek Gertner Institute of Human Genetics Tel Aviv PO Box 52621 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep054"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14636"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.2471"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023008921386"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5908"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1433-2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu034"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.151"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-013-9638-7"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008389021382"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den471"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/9781400835423"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.07.007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.925"},{"key":"e_1_2_12_16_1","unstructured":"HFEA\u2010Human Fertilization and Embryo Authority.(2006).Authority decision on PGD policy.http:\/\/www.hfea.gov.uk\/search.html?fldAdvSearchFor=pgd%2C+brca&fldFilter1=on&x=38&y=12#. 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