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Asymptomatic family members who are gene positive (silent gene carriers) represent a new group of \u201cpatients\u201d who may not develop HCM, with little evidence available to assist clinical management. This study explored experiences of HCM genetic testing to identify potential benefits and harms. Thirty\u2010two individuals previously offered genetic testing for HCM were recruited. Semi\u2010structured interviews were conducted face\u2010to\u2010face or by phone, and transcribed audio\u2010recordings were coded using framework analysis. Key themes were as follows: (1) helping the next generation, (2) misunderstanding risk, (3) discrepancy between actual\/perceived impact. Participants described multiple psychological (shock, worry, uncertainty) and behavioural (career, sport, insurance, family planning) consequences, depending on perceived risk. Most considered only the benefits of genetic testing for children or grandchildren, but there were some cases of significant adverse impact. The interpretation of the HCM genetic test result is variable for silent gene carriers and can lead to psychological and behavioural changes. The impact of a positive gene result may be mitigated by increased clarity of the clinical consequences and efforts to ensure informed decision\u2010making, highlighting even further the important role of cardiac genetic counselling.<\/jats:p>","DOI":"10.1007\/s10897-018-0218-8","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T23:12:00Z","timestamp":1519254720000},"page":"1040-1048","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Psychosocial Impact of a Positive Gene Result for Asymptomatic Relatives at Risk of Hypertrophic Cardiomyopathy"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-6460","authenticated-orcid":false,"given":"Carissa","family":"Bonner","sequence":"first","affiliation":[{"name":"Sydney School of Public Health University of Sydney Rm 126A, Edward Ford Building A27 Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Spinks","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital Camperdown NSW Australia"},{"name":"Agnes Ginges Centre for Molecular Cardiology Centenary Institute Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Semsarian","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital Camperdown NSW Australia"},{"name":"Agnes Ginges Centre for Molecular Cardiology Centenary Institute Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Barratt","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney Rm 126A, Edward Ford Building A27 Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Ingles","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital Camperdown NSW Australia"},{"name":"Agnes Ginges Centre for Molecular Cardiology Centenary Institute Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"McCaffery","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney Rm 126A, Edward Ford Building A27 Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.957365"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.05.020"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.205"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","unstructured":"Caleshu C. 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