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Clinical studies have shown impaired health\u2010related quality of life (HQoL) in adults with NF1. However, little is known about HQoL in non\u2010clinical NF1 samples. We conducted a cross\u2010sectional self\u2010report survey of 142 persons with NF1 (<jats:italic>M<\/jats:italic> age\u2009=\u200950.3 years, SD\u2009=\u200912.0, range 32 to 80; 62.0% females) recruited from non\u2010clinical settings. Several HQoL domains, including life satisfaction, mental health, sleep, pain, gastrointestinal problems, oral health, and social support, were compared between the NF1 sample and 46,293 controls from the HUNT3 population study. We also examined gender differences within the NF1 sample and predictors of HQoL. Compared to controls, the NF1 sample reported significantly poorer life satisfaction, mental health, sleep, and oral health, and more pain, gastrointestinal problems, comorbid diseases, and memory problems. Several HQoL domains were significantly correlated. Mental health was the only unique significant predictor of overall life satisfaction. Women with NF1 reported significantly more mental health, sleep, and pain problems than men with NF1. Mental health assessment and management should be integrated into clinical care of persons with NF1 to potentially improve their HQoL.<\/jats:p>","DOI":"10.1007\/s10897-018-0229-5","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T08:43:32Z","timestamp":1518252212000},"page":"1102-1110","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Health Survey of Adults with Neurofibromatosis 1 Compared to Population Study Controls"],"prefix":"10.1002","volume":"27","author":[{"given":"Krister W.","family":"Fjermestad","sequence":"first","affiliation":[{"name":"Frambu Resource Centre for Rare Disorders Sandbakkvn 18 Siggerud Norway"},{"name":"Department of Psychology University of Oslo P.O. 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