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In this study, 20 interviews were conducted to explore the long\u2010term (&gt;\u20095 years) experiences after receiving predictive test results as a non\u2010carrier of HD. The results showed a broad variety of both positive and negative reactions. The most prominent positive reaction reported was feelings of relief and gratitude, of not carrying the HD mutation for themselves and for their children. Also, the non\u2010carrier status promoted in some individuals\u2019 significant life changes such as a wishing to have (more) children, pursuing a career or breaking up from an unhappy relationship. However, negative reactions on their psychological well\u2010being were also described. Some had experienced psychological pressure of needing to do something extraordinary in their lives; others expressed feelings of guilt towards affected or untested siblings, resulting in sadness or clinical depression. The new genetic risk status could generate a need of re\u2010orientation, a process that for some persons took several years to accomplish. The results of the present study show the importance of offering long\u2010term post\u2010result counselling for non\u2010carriers in order to deal with the psychological consequences that may follow predictive testing.<\/jats:p>","DOI":"10.1007\/s10897-018-0257-1","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T15:07:05Z","timestamp":1524150425000},"page":"1438-1446","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["What to Do with a Second Chance in Life? Long\u2010Term Experiences of Non\u2010carriers of Huntington's Disease"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1438-0986","authenticated-orcid":false,"given":"Elisabeth","family":"Winnberg","sequence":"first","affiliation":[{"name":"Department of Health Care Sciences Ersta Sk\u00f6ndal Br\u00e4cke University College Box 11189 Stockholm SE\u2010100 61 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Winnberg","sequence":"additional","affiliation":[{"name":"Department of Health Care Sciences Ersta Sk\u00f6ndal Br\u00e4cke University College Box 11189 Stockholm SE\u2010100 61 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Pohlkamp","sequence":"additional","affiliation":[{"name":"Department of Health Care Sciences Ersta Sk\u00f6ndal Br\u00e4cke University College Box 11189 Stockholm SE\u2010100 61 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Hagberg","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,7]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Almqvist E. 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