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According to the anthropometric theory, a cranial landmarks identification procedure was applied to retrieve, from a repository, a healthy skull, used as reference geometry for implant modelling. Then, using constrained deformation and free-form modelling techniques, it was possible to design a patient-specific implant. At last, the implant was realised using a custom mould, specially designed according to the patient\u2019s needs to provide an accurate fit of the defect site. The design procedure was tested on a patient suffering from Apert syndrome. Three implants were virtually modelled and 3D-printed for pre-surgical evaluation. Their shapes were 3D compared with a reference one (handcrafted by a surgeon) to test the accuracy. Deviations are negligible, and the customised implant fulfilled the surgeon\u2019s requirements.<\/jats:p>","DOI":"10.1007\/s10916-020-01611-9","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T17:03:31Z","timestamp":1595869411000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Procedure for Designing Custom-Made Implants for Forehead Augmentation in People Suffering from Apert Syndrome"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-5982","authenticated-orcid":false,"given":"Marco","family":"Mandolini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manila","family":"Caragiuli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnese","family":"Brunzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alida","family":"Mazzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Pagnoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"issue":"1","key":"1611_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1108\/09576060010303668","volume":"11","author":"CC Kai","year":"2000","unstructured":"Kai, C.C. 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