{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:44:43Z","timestamp":1788201883959,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Syst"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 2016, we introduced the Danish Prostate Cancer Registry (DaPCaR) which was built on the National Pathology Register from 1995 to 2011. DaPCaR was laborious to use as most data had to be manually imputed with no regular updates. In here we present a new comprehensive centralized prostate registry called the Danish Prostate Registry (DanProst), which includes all men having undergone any histological evaluation of prostate tissue merged with laboratory-, treatment-, prescription data as well as vital status. Here the data included and the methodology of DanProst are described. DanProst is built upon all men with a histological assessment of the prostate from the Danish National Registry for Pathology. The primary histology and potential prostate cancer histological diagnosis for each unique individual is extracted and translated by newly made algorithms for topography, procedure, diagnostic conclusion, and pathological staging. Further information is added from DaPCaR, the CPR Registry, the Danish Cause of Death Registry, the Danish Cancer Registry, the National Patient Registry, the Danish Register of Laboratory Results for Research, and the Danish National Prescription Registry. The translation algorithms were validated based on the comparison with DaPCaR in the period 2010\u20132016. DanProst includes 190,422 men. A total of 95,152 (50%) men are diagnosed with prostate cancer until 2021. Median diagnostic PSA was 11 ng\/ml, most men are diagnosed by ultrasound-guided biopsy (N\u2009=\u200963,751; 67%), and most frequently defined primary treatment was radical prostatectomy (N\u2009=\u200914,778; 19%). DanProst to DaPCaR coherency was &gt;\u200999%, 95%, and 94% for the primary histological procedure, primary histological conclusion, and diagnostic histological conclusion, respectively. DanProst is a continuously updated, centrally kept, validated registry with automatic integration of data from other national registries, allowing for contemporary nationwide analysis in men with histological assessment of the prostate.<\/jats:p>","DOI":"10.1007\/s10916-023-01991-8","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T06:02:32Z","timestamp":1694584952000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Danish Prostate Registry (DanProst) \u2013 an Updated Version of the Danish Prostate Cancer Registry, Methodology, and Early Results"],"prefix":"10.1007","volume":"47","author":[{"given":"Hein Vincent","family":"Stroomberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Benzon","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Sams\u00f8","family":"Lanth\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Kjaer","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. T.","family":"Helgstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Brasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"R\u00f8der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"1991_CR1","doi-asserted-by":"crossref","unstructured":"Gjerstorff ML. The Danish cancer registry. Scand J Public Health. 2011;39.","DOI":"10.1177\/1403494810393562"},{"key":"1991_CR2","doi-asserted-by":"crossref","unstructured":"Schmidt M, Pedersen L, S\u00f8rensen HT. The Danish Civil Registration System as a tool in epidemiology. Eur. J. Epidemiol. 2014.","DOI":"10.1007\/s10654-014-9930-3"},{"key":"1991_CR3","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2147\/CLEP.S114917","volume":"8","author":"JT Helgstrand","year":"2016","unstructured":"Helgstrand JT, Klemann N, R\u00f8der MA, Toft BG, Brasso K, Vainer B, et al. Danish Prostate Cancer Registry \u2013 Methodology and early results from a novel national database. Clin Epidemiol. 2016;8:351\u201360.","journal-title":"Clin Epidemiol"},{"key":"1991_CR4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S1470-2045(17)30025-6","volume":"18","author":"N Klemann","year":"2017","unstructured":"Klemann N, R\u00f8der MA, Helgstrand JT, Brasso K, Toft BG, Vainer B, et al. Risk of prostate cancer diagnosis and mortality in men with a benign initial transrectal ultrasound-guided biopsy set: a population-based study. Lancet Oncol. 2017;18:221\u20139.","journal-title":"Lancet Oncol"},{"key":"1991_CR5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ejca.2017.07.007","volume":"84","author":"JT Helgstrand","year":"2017","unstructured":"Helgstrand JT, R\u00f8der MA, Klemann N, Toft BG, Brasso K, Vainer B, et al. Diagnostic characteristics of lethal prostate cancer. Eur J Cancer. Elsevier Ltd; 2017;84:18\u201326.","journal-title":"Eur J Cancer. Elsevier Ltd"},{"key":"1991_CR6","doi-asserted-by":"crossref","unstructured":"J\u00f8nck S, Thomas Helgstrand J, Andreas R\u00f8der M, Klemann N, Gr\u00f8nkaer Toft B, Brasso K. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis. Scand J Urol. 2018;52.","DOI":"10.1080\/21681805.2018.1534885"},{"key":"1991_CR7","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1002\/cncr.31384","volume":"124","author":"JT Helgstrand","year":"2018","unstructured":"Helgstrand JT, R\u00f8der MA, Klemann N, Toft BG, Lichtensztajn DY, Brooks JD, et al. Trends in incidence and 5-year mortality in men with newly diagnosed, metastatic prostate cancer\u2014A population-based analysis of 2 national cohorts. Cancer. 2018;124:2931\u20138.","journal-title":"Cancer"},{"key":"1991_CR8","doi-asserted-by":"crossref","unstructured":"Friberg AS, Brasso K, Larsen SB, Andersen EW, Kr\u00f8yer A, Helgstrand JT, et al. Risk of depression after diagnostic prostate cancer workup \u2013 A nationwide, registry-based study. Psychooncology. 2021;30.","DOI":"10.1002\/pon.5766"},{"key":"1991_CR9","doi-asserted-by":"crossref","unstructured":"Stroomberg HV, Vojdeman FJ, Madsen CM, Helgstrand JT, Schwarz P, Heegaard AM, et al. Vitamin D levels and the risk of prostate cancer and prostate cancer mortality. Acta Oncol (Madr). Taylor and Francis Ltd.; 2021;60:316\u201322.","DOI":"10.1080\/0284186X.2020.1837391"},{"key":"1991_CR10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.urology.2021.06.007","volume":"155","author":"SM Kawa","year":"2021","unstructured":"Kawa SM, Stroomberg HV, Larsen SB, Helgstrand JT, Toft BG, Brasso K, et al. Detection of Clinically Significant Prostate Cancer by Systematic TRUS-Biopsies in a Population-Based Setting Over a 20 Year Period. Urology. 2021;155:20\u20135.","journal-title":"Urology"},{"key":"1991_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/JU.0000000000002491","volume":"208","author":"SM Kawa","year":"2022","unstructured":"Kawa SM, Stroomberg HV, Larsen SB, Helgstrand JT, Toft BG, Vickers AJ, et al. A Nationwide Analysis of Risk of Prostate Cancer Diagnosis and Mortality following an Initial Negative TRUS-Biopsy with Long-Term Follow-Up. J Urol. 2022;208:100\u20138.","journal-title":"J Urol"},{"key":"1991_CR12","doi-asserted-by":"publisher","unstructured":"Hilscher M, R\u00f8der A, Helgstrand JT, Klemann N, Brasso K, Vickers AJ, et al. Risk of prostate cancer and death after benign transurethral resection of the prostate\u2014A 20-year population\u2010based analysis. Cancer [Internet]. 2022;128:3674\u201380. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/https:\/\/doi.org\/10.1002\/cncr.34407","DOI":"10.1002\/cncr.34407"},{"key":"1991_CR13","doi-asserted-by":"crossref","unstructured":"Stroomberg H V, Andersen MCM, Helgstrand JT, Larsen SB, Vickers AJ, Brasso K, et al. Standardized prostate cancer incidence and mortality rates following initial non-malignant biopsy result. BJU Int. 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Int J Epidemiol. 2016;45.","DOI":"10.1093\/ije\/dyv305"}],"container-title":["Journal of Medical Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-023-01991-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10916-023-01991-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-023-01991-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T06:19:34Z","timestamp":1703830774000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10916-023-01991-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1991"],"URL":"https:\/\/doi.org\/10.1007\/s10916-023-01991-8","relation":{},"ISSN":["1573-689X"],"issn-type":[{"value":"1573-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"3 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"I, Hein Vincent Stroomberg, Ph.D., declare that none of the funding bodies had an influence on the presented manuscript and data. I do declare financial aid outside of the scope of this manuscript\u2014specifically, travel reimbursement, and speaking and lecture fees from MSD Denmark, and project support from Pfizer.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"None of the authors have any competing interests related to the reported work to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"98"}}